The pilocarpine model of epilepsy: what have we learned?
Main Author: | |
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Publication Date: | 2009 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Anais da Academia Brasileira de Ciências (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003 |
Summary: | The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy. |
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The pilocarpine model of epilepsy: what have we learned?hippocampuspilocarpinetemporal lobe epilepsyratThe systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.Academia Brasileira de Ciências2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003Anais da Academia Brasileira de Ciências v.81 n.3 2009reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652009000300003info:eu-repo/semantics/openAccessScorza,Fulvio A.Arida,Ricardo M.Naffah-Mazzacoratti,Maria da GraçaScerni,Débora A.Calderazzo,LineuCavalheiro,Esper A.eng2009-08-19T00:00:00Zoai:scielo:S0001-37652009000300003Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2009-08-19T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
The pilocarpine model of epilepsy: what have we learned? |
title |
The pilocarpine model of epilepsy: what have we learned? |
spellingShingle |
The pilocarpine model of epilepsy: what have we learned? Scorza,Fulvio A. hippocampus pilocarpine temporal lobe epilepsy rat |
title_short |
The pilocarpine model of epilepsy: what have we learned? |
title_full |
The pilocarpine model of epilepsy: what have we learned? |
title_fullStr |
The pilocarpine model of epilepsy: what have we learned? |
title_full_unstemmed |
The pilocarpine model of epilepsy: what have we learned? |
title_sort |
The pilocarpine model of epilepsy: what have we learned? |
author |
Scorza,Fulvio A. |
author_facet |
Scorza,Fulvio A. Arida,Ricardo M. Naffah-Mazzacoratti,Maria da Graça Scerni,Débora A. Calderazzo,Lineu Cavalheiro,Esper A. |
author_role |
author |
author2 |
Arida,Ricardo M. Naffah-Mazzacoratti,Maria da Graça Scerni,Débora A. Calderazzo,Lineu Cavalheiro,Esper A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Scorza,Fulvio A. Arida,Ricardo M. Naffah-Mazzacoratti,Maria da Graça Scerni,Débora A. Calderazzo,Lineu Cavalheiro,Esper A. |
dc.subject.por.fl_str_mv |
hippocampus pilocarpine temporal lobe epilepsy rat |
topic |
hippocampus pilocarpine temporal lobe epilepsy rat |
description |
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652009000300003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.81 n.3 2009 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
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||aabc@abc.org.br |
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1754302857272623104 |