The pilocarpine model of epilepsy: what have we learned?

Detalhes bibliográficos
Autor(a) principal: Scorza,Fulvio A.
Data de Publicação: 2009
Outros Autores: Arida,Ricardo M., Naffah-Mazzacoratti,Maria da Graça, Scerni,Débora A., Calderazzo,Lineu, Cavalheiro,Esper A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003
Resumo: The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.
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spelling The pilocarpine model of epilepsy: what have we learned?hippocampuspilocarpinetemporal lobe epilepsyratThe systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.Academia Brasileira de Ciências2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003Anais da Academia Brasileira de Ciências v.81 n.3 2009reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652009000300003info:eu-repo/semantics/openAccessScorza,Fulvio A.Arida,Ricardo M.Naffah-Mazzacoratti,Maria da GraçaScerni,Débora A.Calderazzo,LineuCavalheiro,Esper A.eng2009-08-19T00:00:00Zoai:scielo:S0001-37652009000300003Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2009-08-19T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv The pilocarpine model of epilepsy: what have we learned?
title The pilocarpine model of epilepsy: what have we learned?
spellingShingle The pilocarpine model of epilepsy: what have we learned?
Scorza,Fulvio A.
hippocampus
pilocarpine
temporal lobe epilepsy
rat
title_short The pilocarpine model of epilepsy: what have we learned?
title_full The pilocarpine model of epilepsy: what have we learned?
title_fullStr The pilocarpine model of epilepsy: what have we learned?
title_full_unstemmed The pilocarpine model of epilepsy: what have we learned?
title_sort The pilocarpine model of epilepsy: what have we learned?
author Scorza,Fulvio A.
author_facet Scorza,Fulvio A.
Arida,Ricardo M.
Naffah-Mazzacoratti,Maria da Graça
Scerni,Débora A.
Calderazzo,Lineu
Cavalheiro,Esper A.
author_role author
author2 Arida,Ricardo M.
Naffah-Mazzacoratti,Maria da Graça
Scerni,Débora A.
Calderazzo,Lineu
Cavalheiro,Esper A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Scorza,Fulvio A.
Arida,Ricardo M.
Naffah-Mazzacoratti,Maria da Graça
Scerni,Débora A.
Calderazzo,Lineu
Cavalheiro,Esper A.
dc.subject.por.fl_str_mv hippocampus
pilocarpine
temporal lobe epilepsy
rat
topic hippocampus
pilocarpine
temporal lobe epilepsy
rat
description The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652009000300003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.81 n.3 2009
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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