Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35721 http://dx.doi.org/10.1590/1414-431X20122477 |
Resumo: | Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. in a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compared to 30 healthy individuals matched for age and gender. Clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were measured. of the 30 patients included in the study, 23 (76.7%) were female and 16 (53.3%) non-Caucasian; mean age was 14 years (range = 4 to 20 years). Mean disease duration was 5 years (range = 1 to 12 years). the mean concentrations of serum albumin-corrected calcium (9.04 +/- 0.41 mg/dL) and alkaline phosphatase (153.3 +/- 100.1 IU) were significantly lower in patients with JIA than in controls (P < 0.0001 and P = 0.001, respectively). No differences in 25(OH)D, PTH or serum phosphorus were observed between JIA and control subjects. Regarding 25(OH)D concentration, 8 patients (26.7%) and 5 controls (16.7%) had 25(OH)D concentrations compatible with deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had concentrations compatible with insufficiency (20-32 ng/mL). These values were not associated with disease activity, use of medications or bone mineral density. We observed a high frequency of 25(OH)D insufficiency and deficiency in the study sample. the compromised bone metabolism emphasizes the importance of follow-up of JIA patients. |
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Munekata, Regina Viviane [UNIFESP]Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Peracchi, Octávio Augusto Bedin [UNIFESP]Len, Claudio Arnaldo [UNIFESP]Lazaretti-Castro, Marise [UNIFESP]Sarni, Roseli Oselka Saccardo [UNIFESP]Hilario, Maria Odete Esteves [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:30:55Z2016-01-24T14:30:55Z2013-01-01Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 98-102, 2013.0100-879Xhttp://repositorio.unifesp.br/handle/11600/35721http://dx.doi.org/10.1590/1414-431X20122477S0100-879X2013000100098.pdfS0100-879X201300010009810.1590/1414-431X20122477WOS:000316126700013Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. in a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compared to 30 healthy individuals matched for age and gender. Clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were measured. of the 30 patients included in the study, 23 (76.7%) were female and 16 (53.3%) non-Caucasian; mean age was 14 years (range = 4 to 20 years). Mean disease duration was 5 years (range = 1 to 12 years). the mean concentrations of serum albumin-corrected calcium (9.04 +/- 0.41 mg/dL) and alkaline phosphatase (153.3 +/- 100.1 IU) were significantly lower in patients with JIA than in controls (P < 0.0001 and P = 0.001, respectively). No differences in 25(OH)D, PTH or serum phosphorus were observed between JIA and control subjects. Regarding 25(OH)D concentration, 8 patients (26.7%) and 5 controls (16.7%) had 25(OH)D concentrations compatible with deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had concentrations compatible with insufficiency (20-32 ng/mL). These values were not associated with disease activity, use of medications or bone mineral density. We observed a high frequency of 25(OH)D insufficiency and deficiency in the study sample. the compromised bone metabolism emphasizes the importance of follow-up of JIA patients.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Pediat, Div Alergia Imunol Clin & Reumatol, Unidade Reumatol Pediat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, Div Alergia Imunol Clin & Reumatol, Unidade Reumatol Pediat, São Paulo, BrazilFAPESP: 08/57420-3Web of Science98-102engAssoc Bras Divulg CientificaBrazilian Journal of Medical and Biological ResearchJuvenile idiopathic arthritisSerum vitamin D deficiencyCalciumAlkaline phosphataseSerum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2013000100098.pdfapplication/pdf76595${dspace.ui.url}/bitstream/11600/35721/1/S0100-879X2013000100098.pdfa57ac7b69885ddc85c26699353a772a9MD51open access11600/357212023-02-15 11:39:38.026open accessoai:repositorio.unifesp.br:11600/35721Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:55.539080Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
title |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
spellingShingle |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis Munekata, Regina Viviane [UNIFESP] Juvenile idiopathic arthritis Serum vitamin D deficiency Calcium Alkaline phosphatase |
title_short |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
title_full |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
title_fullStr |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
title_full_unstemmed |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
title_sort |
Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis |
author |
Munekata, Regina Viviane [UNIFESP] |
author_facet |
Munekata, Regina Viviane [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Peracchi, Octávio Augusto Bedin [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Lazaretti-Castro, Marise [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] Hilario, Maria Odete Esteves [UNIFESP] |
author_role |
author |
author2 |
Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Peracchi, Octávio Augusto Bedin [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Lazaretti-Castro, Marise [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] Hilario, Maria Odete Esteves [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Munekata, Regina Viviane [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Peracchi, Octávio Augusto Bedin [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Lazaretti-Castro, Marise [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] Hilario, Maria Odete Esteves [UNIFESP] |
dc.subject.eng.fl_str_mv |
Juvenile idiopathic arthritis Serum vitamin D deficiency Calcium Alkaline phosphatase |
topic |
Juvenile idiopathic arthritis Serum vitamin D deficiency Calcium Alkaline phosphatase |
description |
Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. in a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compared to 30 healthy individuals matched for age and gender. Clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were measured. of the 30 patients included in the study, 23 (76.7%) were female and 16 (53.3%) non-Caucasian; mean age was 14 years (range = 4 to 20 years). Mean disease duration was 5 years (range = 1 to 12 years). the mean concentrations of serum albumin-corrected calcium (9.04 +/- 0.41 mg/dL) and alkaline phosphatase (153.3 +/- 100.1 IU) were significantly lower in patients with JIA than in controls (P < 0.0001 and P = 0.001, respectively). No differences in 25(OH)D, PTH or serum phosphorus were observed between JIA and control subjects. Regarding 25(OH)D concentration, 8 patients (26.7%) and 5 controls (16.7%) had 25(OH)D concentrations compatible with deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had concentrations compatible with insufficiency (20-32 ng/mL). These values were not associated with disease activity, use of medications or bone mineral density. We observed a high frequency of 25(OH)D insufficiency and deficiency in the study sample. the compromised bone metabolism emphasizes the importance of follow-up of JIA patients. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:30:55Z |
dc.date.available.fl_str_mv |
2016-01-24T14:30:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 98-102, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35721 http://dx.doi.org/10.1590/1414-431X20122477 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2013000100098.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2013000100098 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1414-431X20122477 |
dc.identifier.wos.none.fl_str_mv |
WOS:000316126700013 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 98-102, 2013. 0100-879X S0100-879X2013000100098.pdf S0100-879X2013000100098 10.1590/1414-431X20122477 WOS:000316126700013 |
url |
http://repositorio.unifesp.br/handle/11600/35721 http://dx.doi.org/10.1590/1414-431X20122477 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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openAccess |
dc.format.none.fl_str_mv |
98-102 |
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Assoc Bras Divulg Cientifica |
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Assoc Bras Divulg Cientifica |
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