Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000013 |
Resumo: | The aim of the present study was to investigate the role of bradykinin in the inhibitory action of captopril in hypertension induced by L-NAME in anesthetized rats. Male Wistar rats (260-320 g) were anesthetized with chloralose and arterial blood pressure was recorded with a polygraph pressure transducer. The hypertensive effect of L-NAME was studied in rats pretreated with saline, captopril or HOE 140 plus captopril. The effect of captopril was also studied during the sustained pressor effect of L-NAME. The acute pressor effect of L-NAME (10 mg/kg, iv) was significantly reduced by iv pretreatment with 2 mg/kg captopril (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 49 ± 4.9 mmHg reduced to 20 ± 5.4 mmHg, P = 0.01). The pressor effect of L-NAME (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 38 ± 4.8 mmHg) observed in rats pretreated with captopril and HOE 140 (0.1 mg/kg, iv) was not significantly different from that induced by L-NAME in rats pretreated with saline (P = 0.09). During the sustained pressor effect induced by L-NAME (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 49 ± 4.9 mmHg) captopril induced a significant (P<0.05) reduction in arterial blood pressure (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> decrease of 22 ± 3.0 mmHg). The present results demonstrate that the acute pressor effect of L-NAME is reduced by captopril and this inhibitory effect may be partly dependent on the potentiation of the vasodilator actions of bradykinin |
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Brazilian Journal of Medical and Biological Research |
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Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized ratsL-NAMEThe aim of the present study was to investigate the role of bradykinin in the inhibitory action of captopril in hypertension induced by L-NAME in anesthetized rats. Male Wistar rats (260-320 g) were anesthetized with chloralose and arterial blood pressure was recorded with a polygraph pressure transducer. The hypertensive effect of L-NAME was studied in rats pretreated with saline, captopril or HOE 140 plus captopril. The effect of captopril was also studied during the sustained pressor effect of L-NAME. The acute pressor effect of L-NAME (10 mg/kg, iv) was significantly reduced by iv pretreatment with 2 mg/kg captopril (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 49 ± 4.9 mmHg reduced to 20 ± 5.4 mmHg, P = 0.01). The pressor effect of L-NAME (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 38 ± 4.8 mmHg) observed in rats pretreated with captopril and HOE 140 (0.1 mg/kg, iv) was not significantly different from that induced by L-NAME in rats pretreated with saline (P = 0.09). During the sustained pressor effect induced by L-NAME (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 49 ± 4.9 mmHg) captopril induced a significant (P<0.05) reduction in arterial blood pressure (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> decrease of 22 ± 3.0 mmHg). The present results demonstrate that the acute pressor effect of L-NAME is reduced by captopril and this inhibitory effect may be partly dependent on the potentiation of the vasodilator actions of bradykininAssociação Brasileira de Divulgação Científica1997-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000013Brazilian Journal of Medical and Biological Research v.30 n.10 1997reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1997001000013info:eu-repo/semantics/openAccessSoares de Moura,R.Cardoso,M.eng1998-10-07T00:00:00Zoai:scielo:S0100-879X1997001000013Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1998-10-07T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
title |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
spellingShingle |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats Soares de Moura,R. L-NAME |
title_short |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
title_full |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
title_fullStr |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
title_full_unstemmed |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
title_sort |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats |
author |
Soares de Moura,R. |
author_facet |
Soares de Moura,R. Cardoso,M. |
author_role |
author |
author2 |
Cardoso,M. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Soares de Moura,R. Cardoso,M. |
dc.subject.por.fl_str_mv |
L-NAME |
topic |
L-NAME |
description |
The aim of the present study was to investigate the role of bradykinin in the inhibitory action of captopril in hypertension induced by L-NAME in anesthetized rats. Male Wistar rats (260-320 g) were anesthetized with chloralose and arterial blood pressure was recorded with a polygraph pressure transducer. The hypertensive effect of L-NAME was studied in rats pretreated with saline, captopril or HOE 140 plus captopril. The effect of captopril was also studied during the sustained pressor effect of L-NAME. The acute pressor effect of L-NAME (10 mg/kg, iv) was significantly reduced by iv pretreatment with 2 mg/kg captopril (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 49 ± 4.9 mmHg reduced to 20 ± 5.4 mmHg, P = 0.01). The pressor effect of L-NAME (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 38 ± 4.8 mmHg) observed in rats pretreated with captopril and HOE 140 (0.1 mg/kg, iv) was not significantly different from that induced by L-NAME in rats pretreated with saline (P = 0.09). During the sustained pressor effect induced by L-NAME (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> increase of 49 ± 4.9 mmHg) captopril induced a significant (P<0.05) reduction in arterial blood pressure (<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">D</font> decrease of 22 ± 3.0 mmHg). The present results demonstrate that the acute pressor effect of L-NAME is reduced by captopril and this inhibitory effect may be partly dependent on the potentiation of the vasodilator actions of bradykinin |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1997001000013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.30 n.10 1997 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302928838983680 |