Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices

Detalhes bibliográficos
Autor(a) principal: Moreira,Ana Paula Duarte
Data de Publicação: 2014
Outros Autores: Sader,Márcia Soares, Soares,Gloria Dulce de Almeida, Leão,Maria Helena Miguez Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000400021
Resumo: Strontium (Sr) is known to positively affect the mechanism of bone remodelling. Consequently, calcium phosphate bioceramics associated with alginate matrices containing strontium could improve bone regeneration due to gradual strontium release. This work aims to incorporate Sr on microspheres of alginate (ALG)/β-tricalcium phosphate (β-TCP) and evaluates the in vitro release of strontium ions into a buffer solution at pH 4.0 and 7.4. In this study, strontium chloride was employed as a cross-linking agent and Sr source. Energy dispersive spectroscopy (EDS) showed that strontium was incorporated mainly at the surface of the microspheres produced. The in vitro experiments revealed that there is a rapid strontium release up to 24 h at pH 7.4 due to Sr location on microspheres' surface. At pH 4.0 both calcium and strontium were released due to the β-TCP dissolution.
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spelling Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matricesstrontiummicrospheresalginateβ-TCPdrug delivery systemStrontium (Sr) is known to positively affect the mechanism of bone remodelling. Consequently, calcium phosphate bioceramics associated with alginate matrices containing strontium could improve bone regeneration due to gradual strontium release. This work aims to incorporate Sr on microspheres of alginate (ALG)/β-tricalcium phosphate (β-TCP) and evaluates the in vitro release of strontium ions into a buffer solution at pH 4.0 and 7.4. In this study, strontium chloride was employed as a cross-linking agent and Sr source. Energy dispersive spectroscopy (EDS) showed that strontium was incorporated mainly at the surface of the microspheres produced. The in vitro experiments revealed that there is a rapid strontium release up to 24 h at pH 7.4 due to Sr location on microspheres' surface. At pH 4.0 both calcium and strontium were released due to the β-TCP dissolution.ABM, ABC, ABPol2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000400021Materials Research v.17 n.4 2014reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392014005000095info:eu-repo/semantics/openAccessMoreira,Ana Paula DuarteSader,Márcia SoaresSoares,Gloria Dulce de AlmeidaLeão,Maria Helena Miguez Rochaeng2014-09-16T00:00:00Zoai:scielo:S1516-14392014000400021Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2014-09-16T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
title Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
spellingShingle Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
Moreira,Ana Paula Duarte
strontium
microspheres
alginate
β-TCP
drug delivery system
title_short Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
title_full Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
title_fullStr Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
title_full_unstemmed Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
title_sort Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
author Moreira,Ana Paula Duarte
author_facet Moreira,Ana Paula Duarte
Sader,Márcia Soares
Soares,Gloria Dulce de Almeida
Leão,Maria Helena Miguez Rocha
author_role author
author2 Sader,Márcia Soares
Soares,Gloria Dulce de Almeida
Leão,Maria Helena Miguez Rocha
author2_role author
author
author
dc.contributor.author.fl_str_mv Moreira,Ana Paula Duarte
Sader,Márcia Soares
Soares,Gloria Dulce de Almeida
Leão,Maria Helena Miguez Rocha
dc.subject.por.fl_str_mv strontium
microspheres
alginate
β-TCP
drug delivery system
topic strontium
microspheres
alginate
β-TCP
drug delivery system
description Strontium (Sr) is known to positively affect the mechanism of bone remodelling. Consequently, calcium phosphate bioceramics associated with alginate matrices containing strontium could improve bone regeneration due to gradual strontium release. This work aims to incorporate Sr on microspheres of alginate (ALG)/β-tricalcium phosphate (β-TCP) and evaluates the in vitro release of strontium ions into a buffer solution at pH 4.0 and 7.4. In this study, strontium chloride was employed as a cross-linking agent and Sr source. Energy dispersive spectroscopy (EDS) showed that strontium was incorporated mainly at the surface of the microspheres produced. The in vitro experiments revealed that there is a rapid strontium release up to 24 h at pH 7.4 due to Sr location on microspheres' surface. At pH 4.0 both calcium and strontium were released due to the β-TCP dissolution.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000400021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000400021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-14392014005000095
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.17 n.4 2014
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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