Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900003 |
Resumo: | OBJECTIVE: It was to analyze clinical aspects of patients with blepharospasm, including outcomes of botulinum toxin treatment. Additionally, clinical characteristics of isolated blepharospasm were compared to those of blepharospasm plus other movement disorders. METHODS: Clinical data recorded during 17 years were reviewed. The variables included age, gender, age of onset, past medical history, head trauma, smoking history, family history of dystonia, severity, duration of botulinum toxin relief and adverse effects. RESULTS: A total of 125 patients were included and 75.2% were female. The mean age of onset was 54.3 years; 89.6% of the individuals started with contractions in eye region, and 39.2% of them spread to lower face or neck. Isolated blepharospasm group was compared with blepharospasm-plus group for demographic and clinical features, and therapeutic outcomes, without significant differences. Botulinum toxin treatment improved the severity of contractions (p=0.01) with low rate of side effects (14%). CONCLUSIONS: Both groups - isolated blepharospasm and blepharospasm-plus - shared similar results concerning epidemiology, clinical features and therapeutic response to botulinum toxin. |
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Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experienceblepharospasmbotulinum toxinsOBJECTIVE: It was to analyze clinical aspects of patients with blepharospasm, including outcomes of botulinum toxin treatment. Additionally, clinical characteristics of isolated blepharospasm were compared to those of blepharospasm plus other movement disorders. METHODS: Clinical data recorded during 17 years were reviewed. The variables included age, gender, age of onset, past medical history, head trauma, smoking history, family history of dystonia, severity, duration of botulinum toxin relief and adverse effects. RESULTS: A total of 125 patients were included and 75.2% were female. The mean age of onset was 54.3 years; 89.6% of the individuals started with contractions in eye region, and 39.2% of them spread to lower face or neck. Isolated blepharospasm group was compared with blepharospasm-plus group for demographic and clinical features, and therapeutic outcomes, without significant differences. Botulinum toxin treatment improved the severity of contractions (p=0.01) with low rate of side effects (14%). CONCLUSIONS: Both groups - isolated blepharospasm and blepharospasm-plus - shared similar results concerning epidemiology, clinical features and therapeutic response to botulinum toxin.Academia Brasileira de Neurologia - ABNEURO2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900003Arquivos de Neuro-Psiquiatria v.70 n.9 2012reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012000900003info:eu-repo/semantics/openAccessAquino,Camila CatherineFelício,Andre C.Castro,Pollyanna Celso Felipe deOliveira,Ricardo AraujoSilva,Sonia Maria Cesar AzevedoBorges,VanderciFerraz,Henrique Ballalaieng2012-09-12T00:00:00Zoai:scielo:S0004-282X2012000900003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2012-09-12T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
title |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
spellingShingle |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience Aquino,Camila Catherine blepharospasm botulinum toxins |
title_short |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
title_full |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
title_fullStr |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
title_full_unstemmed |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
title_sort |
Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience |
author |
Aquino,Camila Catherine |
author_facet |
Aquino,Camila Catherine Felício,Andre C. Castro,Pollyanna Celso Felipe de Oliveira,Ricardo Araujo Silva,Sonia Maria Cesar Azevedo Borges,Vanderci Ferraz,Henrique Ballalai |
author_role |
author |
author2 |
Felício,Andre C. Castro,Pollyanna Celso Felipe de Oliveira,Ricardo Araujo Silva,Sonia Maria Cesar Azevedo Borges,Vanderci Ferraz,Henrique Ballalai |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Aquino,Camila Catherine Felício,Andre C. Castro,Pollyanna Celso Felipe de Oliveira,Ricardo Araujo Silva,Sonia Maria Cesar Azevedo Borges,Vanderci Ferraz,Henrique Ballalai |
dc.subject.por.fl_str_mv |
blepharospasm botulinum toxins |
topic |
blepharospasm botulinum toxins |
description |
OBJECTIVE: It was to analyze clinical aspects of patients with blepharospasm, including outcomes of botulinum toxin treatment. Additionally, clinical characteristics of isolated blepharospasm were compared to those of blepharospasm plus other movement disorders. METHODS: Clinical data recorded during 17 years were reviewed. The variables included age, gender, age of onset, past medical history, head trauma, smoking history, family history of dystonia, severity, duration of botulinum toxin relief and adverse effects. RESULTS: A total of 125 patients were included and 75.2% were female. The mean age of onset was 54.3 years; 89.6% of the individuals started with contractions in eye region, and 39.2% of them spread to lower face or neck. Isolated blepharospasm group was compared with blepharospasm-plus group for demographic and clinical features, and therapeutic outcomes, without significant differences. Botulinum toxin treatment improved the severity of contractions (p=0.01) with low rate of side effects (14%). CONCLUSIONS: Both groups - isolated blepharospasm and blepharospasm-plus - shared similar results concerning epidemiology, clinical features and therapeutic response to botulinum toxin. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2012000900003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.70 n.9 2012 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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