Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome

Detalhes bibliográficos
Autor(a) principal: Jardim,Anaclara Prada
Data de Publicação: 2012
Outros Autores: Neves,Rafael Scarpa da Costa, Caboclo,Luís Otávio Sales Ferreira, Lancellotti,Carmen Lucia Penteado, Marinho,Murilo Martinez, Centeno,Ricardo Silva, Cavalheiro,Esper Abrão, Scorza,Carla Alessandra, Yacubian,Elza Márcia Targas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500003
Resumo: OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.
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spelling Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcomeepilepsytemporal lobemesial temporal sclerosishippocampal sclerosispathologysurgical prognosisOBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.Academia Brasileira de Neurologia - ABNEURO2012-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500003Arquivos de Neuro-Psiquiatria v.70 n.5 2012reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2012000500003info:eu-repo/semantics/openAccessJardim,Anaclara PradaNeves,Rafael Scarpa da CostaCaboclo,Luís Otávio Sales FerreiraLancellotti,Carmen Lucia PenteadoMarinho,Murilo MartinezCenteno,Ricardo SilvaCavalheiro,Esper AbrãoScorza,Carla AlessandraYacubian,Elza Márcia Targaseng2012-05-15T00:00:00Zoai:scielo:S0004-282X2012000500003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2012-05-15T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
title Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
spellingShingle Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
Jardim,Anaclara Prada
epilepsy
temporal lobe
mesial temporal sclerosis
hippocampal sclerosis
pathology
surgical prognosis
title_short Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
title_full Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
title_fullStr Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
title_full_unstemmed Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
title_sort Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
author Jardim,Anaclara Prada
author_facet Jardim,Anaclara Prada
Neves,Rafael Scarpa da Costa
Caboclo,Luís Otávio Sales Ferreira
Lancellotti,Carmen Lucia Penteado
Marinho,Murilo Martinez
Centeno,Ricardo Silva
Cavalheiro,Esper Abrão
Scorza,Carla Alessandra
Yacubian,Elza Márcia Targas
author_role author
author2 Neves,Rafael Scarpa da Costa
Caboclo,Luís Otávio Sales Ferreira
Lancellotti,Carmen Lucia Penteado
Marinho,Murilo Martinez
Centeno,Ricardo Silva
Cavalheiro,Esper Abrão
Scorza,Carla Alessandra
Yacubian,Elza Márcia Targas
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jardim,Anaclara Prada
Neves,Rafael Scarpa da Costa
Caboclo,Luís Otávio Sales Ferreira
Lancellotti,Carmen Lucia Penteado
Marinho,Murilo Martinez
Centeno,Ricardo Silva
Cavalheiro,Esper Abrão
Scorza,Carla Alessandra
Yacubian,Elza Márcia Targas
dc.subject.por.fl_str_mv epilepsy
temporal lobe
mesial temporal sclerosis
hippocampal sclerosis
pathology
surgical prognosis
topic epilepsy
temporal lobe
mesial temporal sclerosis
hippocampal sclerosis
pathology
surgical prognosis
description OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.
publishDate 2012
dc.date.none.fl_str_mv 2012-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2012000500003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.70 n.5 2012
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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