Restless legs syndrome in Parkinson's disease and increased cardiovascular risk
Main Author: | |
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Publication Date: | 2018 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Arquivos de neuro-psiquiatria (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731 |
Summary: | ABSTRACT Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores. Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors. Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated. |
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Restless legs syndrome in Parkinson's disease and increased cardiovascular riskParkinson diseaserestless legs syndromecardiovascular diseasesdyslipidemiasABSTRACT Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores. Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors. Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated.Academia Brasileira de Neurologia - ABNEURO2018-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731Arquivos de Neuro-Psiquiatria v.76 n.11 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180114info:eu-repo/semantics/openAccessSilva,Maren de Moraes eLorenzi,Cezar HenriqueSchneider,Blenda BarretoSeidel,Catherine Enk FischerSalomé,IsabelaGianini,Viktor Cleto MoraisPessoa,Renata RaminaMercer,Pilar Bueno SiqueiraWitt,Maria Carolina Zavagnaeng2018-12-10T00:00:00Zoai:scielo:S0004-282X2018001100731Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-12-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
title |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
spellingShingle |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk Silva,Maren de Moraes e Parkinson disease restless legs syndrome cardiovascular diseases dyslipidemias |
title_short |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
title_full |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
title_fullStr |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
title_full_unstemmed |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
title_sort |
Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
author |
Silva,Maren de Moraes e |
author_facet |
Silva,Maren de Moraes e Lorenzi,Cezar Henrique Schneider,Blenda Barreto Seidel,Catherine Enk Fischer Salomé,Isabela Gianini,Viktor Cleto Morais Pessoa,Renata Ramina Mercer,Pilar Bueno Siqueira Witt,Maria Carolina Zavagna |
author_role |
author |
author2 |
Lorenzi,Cezar Henrique Schneider,Blenda Barreto Seidel,Catherine Enk Fischer Salomé,Isabela Gianini,Viktor Cleto Morais Pessoa,Renata Ramina Mercer,Pilar Bueno Siqueira Witt,Maria Carolina Zavagna |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Maren de Moraes e Lorenzi,Cezar Henrique Schneider,Blenda Barreto Seidel,Catherine Enk Fischer Salomé,Isabela Gianini,Viktor Cleto Morais Pessoa,Renata Ramina Mercer,Pilar Bueno Siqueira Witt,Maria Carolina Zavagna |
dc.subject.por.fl_str_mv |
Parkinson disease restless legs syndrome cardiovascular diseases dyslipidemias |
topic |
Parkinson disease restless legs syndrome cardiovascular diseases dyslipidemias |
description |
ABSTRACT Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores. Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors. Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180114 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.11 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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