Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect

Detalhes bibliográficos
Autor(a) principal: Piovesan,Elcio J
Data de Publicação: 2016
Outros Autores: Oshinsky,Michael, Silberstein,Stephen, Kowacs,Pedro Andre, Novak,Edison Matos, Werneck,Lineu Cesar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462
Resumo: ABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals.
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spelling Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effectanalgesicsbotulinum toxinsfacial paintrigeminal neuralgiaABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals.Academia Brasileira de Neurologia - ABNEURO2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462Arquivos de Neuro-Psiquiatria v.74 n.6 2016reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20160067info:eu-repo/semantics/openAccessPiovesan,Elcio JOshinsky,MichaelSilberstein,StephenKowacs,Pedro AndreNovak,Edison MatosWerneck,Lineu Cesareng2017-01-11T00:00:00Zoai:scielo:S0004-282X2016000600462Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2017-01-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
title Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
spellingShingle Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
Piovesan,Elcio J
analgesics
botulinum toxins
facial pain
trigeminal neuralgia
title_short Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
title_full Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
title_fullStr Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
title_full_unstemmed Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
title_sort Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
author Piovesan,Elcio J
author_facet Piovesan,Elcio J
Oshinsky,Michael
Silberstein,Stephen
Kowacs,Pedro Andre
Novak,Edison Matos
Werneck,Lineu Cesar
author_role author
author2 Oshinsky,Michael
Silberstein,Stephen
Kowacs,Pedro Andre
Novak,Edison Matos
Werneck,Lineu Cesar
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Piovesan,Elcio J
Oshinsky,Michael
Silberstein,Stephen
Kowacs,Pedro Andre
Novak,Edison Matos
Werneck,Lineu Cesar
dc.subject.por.fl_str_mv analgesics
botulinum toxins
facial pain
trigeminal neuralgia
topic analgesics
botulinum toxins
facial pain
trigeminal neuralgia
description ABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20160067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.74 n.6 2016
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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