Anticonvulsants to treat idiopathic restless legs syndrome: systematic review
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300034 |
Resumo: | BACKGROUND: Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. Many treatments have been used to minimize the discomfort of the disease, among them the anticonvulsant therapy. AIM: This review aims to evaluate the efficacy and safety of anticonvulsant treatment for idiopathic RLS. METHOD: Systematic review of randomized or quasi-randomized, double blind trials on anticonvulsant treatment for RLS. Outcomes: relief of RLS symptoms, subjective and objective sleep quality, quality of life, and adverse events associated with the treatments. RESULTS: A total of 231 patients were randomized in three cross over studies and one parallel study. Three studies with carbamazepine, one with sodium valproate, and one with gabapentin, and they were very heterogeneous so we could not perform a metanalyses. CONCLUSIONS: There is no scientific evidence on RLS treatment with anticonvulsants for clinical practice. |
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Anticonvulsants to treat idiopathic restless legs syndrome: systematic reviewrestless legsanticonvulsantBACKGROUND: Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. Many treatments have been used to minimize the discomfort of the disease, among them the anticonvulsant therapy. AIM: This review aims to evaluate the efficacy and safety of anticonvulsant treatment for idiopathic RLS. METHOD: Systematic review of randomized or quasi-randomized, double blind trials on anticonvulsant treatment for RLS. Outcomes: relief of RLS symptoms, subjective and objective sleep quality, quality of life, and adverse events associated with the treatments. RESULTS: A total of 231 patients were randomized in three cross over studies and one parallel study. Three studies with carbamazepine, one with sodium valproate, and one with gabapentin, and they were very heterogeneous so we could not perform a metanalyses. CONCLUSIONS: There is no scientific evidence on RLS treatment with anticonvulsants for clinical practice.Academia Brasileira de Neurologia - ABNEURO2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300034Arquivos de Neuro-Psiquiatria v.66 n.2b 2008reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2008000300034info:eu-repo/semantics/openAccessConti,Cristiane FiqueneOliveira,Márcio Moysés deValbuza,Juliana SpeltaPrado,Lucila Bizari F.Carvalho,Luciane Bizari Coin dePrado,Gilmar Fernandes doeng2008-09-29T00:00:00Zoai:scielo:S0004-282X2008000300034Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-09-29T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
title |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
spellingShingle |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review Conti,Cristiane Fiquene restless legs anticonvulsant |
title_short |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
title_full |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
title_fullStr |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
title_full_unstemmed |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
title_sort |
Anticonvulsants to treat idiopathic restless legs syndrome: systematic review |
author |
Conti,Cristiane Fiquene |
author_facet |
Conti,Cristiane Fiquene Oliveira,Márcio Moysés de Valbuza,Juliana Spelta Prado,Lucila Bizari F. Carvalho,Luciane Bizari Coin de Prado,Gilmar Fernandes do |
author_role |
author |
author2 |
Oliveira,Márcio Moysés de Valbuza,Juliana Spelta Prado,Lucila Bizari F. Carvalho,Luciane Bizari Coin de Prado,Gilmar Fernandes do |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Conti,Cristiane Fiquene Oliveira,Márcio Moysés de Valbuza,Juliana Spelta Prado,Lucila Bizari F. Carvalho,Luciane Bizari Coin de Prado,Gilmar Fernandes do |
dc.subject.por.fl_str_mv |
restless legs anticonvulsant |
topic |
restless legs anticonvulsant |
description |
BACKGROUND: Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. Many treatments have been used to minimize the discomfort of the disease, among them the anticonvulsant therapy. AIM: This review aims to evaluate the efficacy and safety of anticonvulsant treatment for idiopathic RLS. METHOD: Systematic review of randomized or quasi-randomized, double blind trials on anticonvulsant treatment for RLS. Outcomes: relief of RLS symptoms, subjective and objective sleep quality, quality of life, and adverse events associated with the treatments. RESULTS: A total of 231 patients were randomized in three cross over studies and one parallel study. Three studies with carbamazepine, one with sodium valproate, and one with gabapentin, and they were very heterogeneous so we could not perform a metanalyses. CONCLUSIONS: There is no scientific evidence on RLS treatment with anticonvulsants for clinical practice. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300034 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300034 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2008000300034 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.66 n.2b 2008 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212764038987776 |