Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007 |
Resumo: | OBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. METHOD: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. RESULTS: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. CONCLUSION: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions. |
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Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literaturemultiple sclerosisrestless legs syndromemeta-analysisOBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. METHOD: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. RESULTS: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. CONCLUSION: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions.Academia Brasileira de Neurologia - ABNEURO2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007Arquivos de Neuro-Psiquiatria v.69 n.2a 2011reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2011000200007info:eu-repo/semantics/openAccessFragoso,Yára DadaltiFinkelsztejn,AlessandroGomes,SidneyMaciel,Damacio Ramon KaimenOliveira,Celso Luis S.Lopes,JosianeCristovam,Rafael A.eng2011-04-26T00:00:00Zoai:scielo:S0004-282X2011000200007Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-04-26T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
title |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
spellingShingle |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature Fragoso,Yára Dadalti multiple sclerosis restless legs syndrome meta-analysis |
title_short |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
title_full |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
title_fullStr |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
title_full_unstemmed |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
title_sort |
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
author |
Fragoso,Yára Dadalti |
author_facet |
Fragoso,Yára Dadalti Finkelsztejn,Alessandro Gomes,Sidney Maciel,Damacio Ramon Kaimen Oliveira,Celso Luis S. Lopes,Josiane Cristovam,Rafael A. |
author_role |
author |
author2 |
Finkelsztejn,Alessandro Gomes,Sidney Maciel,Damacio Ramon Kaimen Oliveira,Celso Luis S. Lopes,Josiane Cristovam,Rafael A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fragoso,Yára Dadalti Finkelsztejn,Alessandro Gomes,Sidney Maciel,Damacio Ramon Kaimen Oliveira,Celso Luis S. Lopes,Josiane Cristovam,Rafael A. |
dc.subject.por.fl_str_mv |
multiple sclerosis restless legs syndrome meta-analysis |
topic |
multiple sclerosis restless legs syndrome meta-analysis |
description |
OBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. METHOD: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. RESULTS: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. CONCLUSION: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2011000200007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.69 n.2a 2011 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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