Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis

Detalhes bibliográficos
Autor(a) principal: Mazzali,Marilda
Data de Publicação: 1999
Outros Autores: Ribeiro-Alves,Maria Almerinda Vieira Fernandes, Alves Filho,Gentil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801999000200003
Resumo: CONTEXT: Renal allograft biopsies have been used as a good method for monitoring the evolution of kidney transplants for at least 20 years.1 Histological analysis permits differential diagnosis of the causes of allograft dysfunction to be made. OBJECTIVES: To correlate the data of urinalysis and serum creatinine with histological diagnosis of renal graft in a group of renal transplant patients. DESIGN: Accuracy study, retrospective analysis. SETTING: A university terciary referral center. SAMPLE: 339 percutaneous allograft biopsies obtained from 153 patients. Blood and urine samples were obtained before the graft biopsy. MAIN MEASUREMENTS: Laboratory evaluation and hystological analysis (light microscopy, imunofluorescent eletronic microscopy). RESULTS: Most of the biopsies (58.9%) were performed during the first month post-transplant. An increase in serum creatinine was associated with acute tubular and/or cortical necrosis. Proteinuria and normal serum creatinine were associated with glomerular lesions. Non-nephrotic range proteinuria and an increase in serum creatinine were associated with chronic rejection. CONCLUSIONS: Evaluation of serum creatinine and urinalysis can be useful in suggesting the histological graft diagnosis.
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spelling Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysisKidney transplantationRenal biopsyAcute rejectionAcute tubular necrosisGlomerulonephritisCONTEXT: Renal allograft biopsies have been used as a good method for monitoring the evolution of kidney transplants for at least 20 years.1 Histological analysis permits differential diagnosis of the causes of allograft dysfunction to be made. OBJECTIVES: To correlate the data of urinalysis and serum creatinine with histological diagnosis of renal graft in a group of renal transplant patients. DESIGN: Accuracy study, retrospective analysis. SETTING: A university terciary referral center. SAMPLE: 339 percutaneous allograft biopsies obtained from 153 patients. Blood and urine samples were obtained before the graft biopsy. MAIN MEASUREMENTS: Laboratory evaluation and hystological analysis (light microscopy, imunofluorescent eletronic microscopy). RESULTS: Most of the biopsies (58.9%) were performed during the first month post-transplant. An increase in serum creatinine was associated with acute tubular and/or cortical necrosis. Proteinuria and normal serum creatinine were associated with glomerular lesions. Non-nephrotic range proteinuria and an increase in serum creatinine were associated with chronic rejection. CONCLUSIONS: Evaluation of serum creatinine and urinalysis can be useful in suggesting the histological graft diagnosis.Associação Paulista de Medicina - APM1999-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801999000200003Sao Paulo Medical Journal v.117 n.2 1999reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801999000200003info:eu-repo/semantics/openAccessMazzali,MarildaRibeiro-Alves,Maria Almerinda Vieira FernandesAlves Filho,Gentileng1999-10-04T00:00:00Zoai:scielo:S1516-31801999000200003Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:1999-10-04T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
title Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
spellingShingle Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
Mazzali,Marilda
Kidney transplantation
Renal biopsy
Acute rejection
Acute tubular necrosis
Glomerulonephritis
title_short Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
title_full Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
title_fullStr Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
title_full_unstemmed Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
title_sort Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis
author Mazzali,Marilda
author_facet Mazzali,Marilda
Ribeiro-Alves,Maria Almerinda Vieira Fernandes
Alves Filho,Gentil
author_role author
author2 Ribeiro-Alves,Maria Almerinda Vieira Fernandes
Alves Filho,Gentil
author2_role author
author
dc.contributor.author.fl_str_mv Mazzali,Marilda
Ribeiro-Alves,Maria Almerinda Vieira Fernandes
Alves Filho,Gentil
dc.subject.por.fl_str_mv Kidney transplantation
Renal biopsy
Acute rejection
Acute tubular necrosis
Glomerulonephritis
topic Kidney transplantation
Renal biopsy
Acute rejection
Acute tubular necrosis
Glomerulonephritis
description CONTEXT: Renal allograft biopsies have been used as a good method for monitoring the evolution of kidney transplants for at least 20 years.1 Histological analysis permits differential diagnosis of the causes of allograft dysfunction to be made. OBJECTIVES: To correlate the data of urinalysis and serum creatinine with histological diagnosis of renal graft in a group of renal transplant patients. DESIGN: Accuracy study, retrospective analysis. SETTING: A university terciary referral center. SAMPLE: 339 percutaneous allograft biopsies obtained from 153 patients. Blood and urine samples were obtained before the graft biopsy. MAIN MEASUREMENTS: Laboratory evaluation and hystological analysis (light microscopy, imunofluorescent eletronic microscopy). RESULTS: Most of the biopsies (58.9%) were performed during the first month post-transplant. An increase in serum creatinine was associated with acute tubular and/or cortical necrosis. Proteinuria and normal serum creatinine were associated with glomerular lesions. Non-nephrotic range proteinuria and an increase in serum creatinine were associated with chronic rejection. CONCLUSIONS: Evaluation of serum creatinine and urinalysis can be useful in suggesting the histological graft diagnosis.
publishDate 1999
dc.date.none.fl_str_mv 1999-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801999000200003
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31801999000200003
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.117 n.2 1999
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
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institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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