Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000300004 |
Resumo: | We studied the effects of protein-energy malnutrition on the liver morphology of rats as compared to animal emaciation and to reduction in size of the organs not irrigated by splanchnic blood such as kidneys and spleen. The animals were divided into two groups, one of them fed ad libitum rate (N=10) and the other (N=14) receiving water but no food for 7 days, and the changes in animal weight, liver, kidney and spleen mass were determined. DNA and the protein/DNA ratio, as well as hepatocyte size, were determined in liver tissue. The liver decreased in mass (27.14%) at a significantly higher proportion (p<0.05) when compared to body emaciation (19.22%). Similar to the reduction in body weight, the masses of kidneys and spleen were reduced by 18.68% and 24.28%, respectively. The reduction in liver mass occurred due to hypoplasia and atrophy, i.e., a decrease in hepatocyte number and size, respectively. We conclude that there is a preferential consumption of liver protein in protein-energy malnutrition which is suggested to result from the additive action of the effects of overall consumption of organic reserves due to malnutrition proper and to the reduction of the hepatotrophic stimulus. |
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Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal systemAtrophyLiverGlucagonInsulinLiver regenerationMalnutritionStarvationWe studied the effects of protein-energy malnutrition on the liver morphology of rats as compared to animal emaciation and to reduction in size of the organs not irrigated by splanchnic blood such as kidneys and spleen. The animals were divided into two groups, one of them fed ad libitum rate (N=10) and the other (N=14) receiving water but no food for 7 days, and the changes in animal weight, liver, kidney and spleen mass were determined. DNA and the protein/DNA ratio, as well as hepatocyte size, were determined in liver tissue. The liver decreased in mass (27.14%) at a significantly higher proportion (p<0.05) when compared to body emaciation (19.22%). Similar to the reduction in body weight, the masses of kidneys and spleen were reduced by 18.68% and 24.28%, respectively. The reduction in liver mass occurred due to hypoplasia and atrophy, i.e., a decrease in hepatocyte number and size, respectively. We conclude that there is a preferential consumption of liver protein in protein-energy malnutrition which is suggested to result from the additive action of the effects of overall consumption of organic reserves due to malnutrition proper and to the reduction of the hepatotrophic stimulus.Associação Paulista de Medicina - APM1995-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000300004Sao Paulo Medical Journal v.113 n.3 1995reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801995000300004info:eu-repo/semantics/openAccessParra,Osório MiguelHernandez-Blasquez,Francisco JavierSilva,Rubens Augusto Penteado de Sousa eSilva,José Roberto Machado Cunha daPeduto,LuigiSoares,Magna MaltauroSaad,William AbrãoSaad Junior,William Abrãoeng2009-05-29T00:00:00Zoai:scielo:S1516-31801995000300004Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2009-05-29T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
title |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
spellingShingle |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system Parra,Osório Miguel Atrophy Liver Glucagon Insulin Liver regeneration Malnutrition Starvation |
title_short |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
title_full |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
title_fullStr |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
title_full_unstemmed |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
title_sort |
Reduction of liver mass due to malnutrition in rats: correlation with emaciation of animals and size of organs not inserted in the portal system |
author |
Parra,Osório Miguel |
author_facet |
Parra,Osório Miguel Hernandez-Blasquez,Francisco Javier Silva,Rubens Augusto Penteado de Sousa e Silva,José Roberto Machado Cunha da Peduto,Luigi Soares,Magna Maltauro Saad,William Abrão Saad Junior,William Abrão |
author_role |
author |
author2 |
Hernandez-Blasquez,Francisco Javier Silva,Rubens Augusto Penteado de Sousa e Silva,José Roberto Machado Cunha da Peduto,Luigi Soares,Magna Maltauro Saad,William Abrão Saad Junior,William Abrão |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Parra,Osório Miguel Hernandez-Blasquez,Francisco Javier Silva,Rubens Augusto Penteado de Sousa e Silva,José Roberto Machado Cunha da Peduto,Luigi Soares,Magna Maltauro Saad,William Abrão Saad Junior,William Abrão |
dc.subject.por.fl_str_mv |
Atrophy Liver Glucagon Insulin Liver regeneration Malnutrition Starvation |
topic |
Atrophy Liver Glucagon Insulin Liver regeneration Malnutrition Starvation |
description |
We studied the effects of protein-energy malnutrition on the liver morphology of rats as compared to animal emaciation and to reduction in size of the organs not irrigated by splanchnic blood such as kidneys and spleen. The animals were divided into two groups, one of them fed ad libitum rate (N=10) and the other (N=14) receiving water but no food for 7 days, and the changes in animal weight, liver, kidney and spleen mass were determined. DNA and the protein/DNA ratio, as well as hepatocyte size, were determined in liver tissue. The liver decreased in mass (27.14%) at a significantly higher proportion (p<0.05) when compared to body emaciation (19.22%). Similar to the reduction in body weight, the masses of kidneys and spleen were reduced by 18.68% and 24.28%, respectively. The reduction in liver mass occurred due to hypoplasia and atrophy, i.e., a decrease in hepatocyte number and size, respectively. We conclude that there is a preferential consumption of liver protein in protein-energy malnutrition which is suggested to result from the additive action of the effects of overall consumption of organic reserves due to malnutrition proper and to the reduction of the hepatotrophic stimulus. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000300004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000300004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31801995000300004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.113 n.3 1995 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209259219845120 |