Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review

• Autor(a) principal: Alvarenga,César Augusto
• Data de Publicação: 2012
• Outros Autores: Lopes,José Manuel, Vinagre,João, Paravidino,Paula Itagyba, Alvarenga,Marcelo, Prando,Adilson, Castilho,Lísias Nogueira, Soares,Paula, Billis,Athanase
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: São Paulo medical journal (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000100010
• topic: Paraganglioma; Carcinoma, renal cell; Seminal vesicles; Kidney neoplasms; Mutation

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.