Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200009 |
Resumo: | Hepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C experience thyroid problems, and thyroid dysfunction may also be a side effect of interferon-based treatment. The principal risk factor for developing thyroid disease in the course of antiviral therapy is the previous positivity for anti-thyroid antibodies (anti-thyroid peroxidase) especially in older women. Screening for autoantibodies and serum thyroid-stimulating hormone is recommended before, during and after interferon-alpha treatment, and patients should be informed of the risk of thyroid dysfunction. This review includes a summary of thyroid disease associated with chronic HCV infection, interferon-alpha and ribavirin for treatment of HCV and potential to induce thyroid dysfunction. |
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Brazilian Journal of Infectious Diseases |
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Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a reviewHepatitis Cinterferon-alpharibavirinthyroid dysfunctionthyroiditisHepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C experience thyroid problems, and thyroid dysfunction may also be a side effect of interferon-based treatment. The principal risk factor for developing thyroid disease in the course of antiviral therapy is the previous positivity for anti-thyroid antibodies (anti-thyroid peroxidase) especially in older women. Screening for autoantibodies and serum thyroid-stimulating hormone is recommended before, during and after interferon-alpha treatment, and patients should be informed of the risk of thyroid dysfunction. This review includes a summary of thyroid disease associated with chronic HCV infection, interferon-alpha and ribavirin for treatment of HCV and potential to induce thyroid dysfunction.Brazilian Society of Infectious Diseases2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200009Brazilian Journal of Infectious Diseases v.12 n.2 2008reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702008000200009info:eu-repo/semantics/openAccessAndrade,Luis Jesuíno de OliveiraAtta,Ajax MercêsD'Almeida Junior,ArgemiroParaná,Raymundoeng2008-07-15T00:00:00Zoai:scielo:S1413-86702008000200009Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2008-07-15T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
title |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
spellingShingle |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review Andrade,Luis Jesuíno de Oliveira Hepatitis C interferon-alpha ribavirin thyroid dysfunction thyroiditis |
title_short |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
title_full |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
title_fullStr |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
title_full_unstemmed |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
title_sort |
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review |
author |
Andrade,Luis Jesuíno de Oliveira |
author_facet |
Andrade,Luis Jesuíno de Oliveira Atta,Ajax Mercês D'Almeida Junior,Argemiro Paraná,Raymundo |
author_role |
author |
author2 |
Atta,Ajax Mercês D'Almeida Junior,Argemiro Paraná,Raymundo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Andrade,Luis Jesuíno de Oliveira Atta,Ajax Mercês D'Almeida Junior,Argemiro Paraná,Raymundo |
dc.subject.por.fl_str_mv |
Hepatitis C interferon-alpha ribavirin thyroid dysfunction thyroiditis |
topic |
Hepatitis C interferon-alpha ribavirin thyroid dysfunction thyroiditis |
description |
Hepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C experience thyroid problems, and thyroid dysfunction may also be a side effect of interferon-based treatment. The principal risk factor for developing thyroid disease in the course of antiviral therapy is the previous positivity for anti-thyroid antibodies (anti-thyroid peroxidase) especially in older women. Screening for autoantibodies and serum thyroid-stimulating hormone is recommended before, during and after interferon-alpha treatment, and patients should be informed of the risk of thyroid dysfunction. This review includes a summary of thyroid disease associated with chronic HCV infection, interferon-alpha and ribavirin for treatment of HCV and potential to induce thyroid dysfunction. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702008000200009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.12 n.2 2008 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209240266833920 |