The hepatopulmonary syndrome

Detalhes bibliográficos
Autor(a) principal: NACIF,Lucas Souto
Data de Publicação: 2014
Outros Autores: ANDRAUS,Wellington, PINHEIRO,Rafael Soares, DUCATTI,Liliana, HADDAD,Luciana BP, D'ALBUQUERQUE,Luiz Carneiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202014000200145
Resumo: INTRODUCTION: The hepatopulmonary syndrome has been acknowledged as an important vascular complication in lungs developing systemic hypoxemia in patients with cirrhosis and portal hypertension. Is formed by arterial oxygenation abnormalities induced from intrapulmonary vascular dilatations with liver disease. It is present in 4-32% of patients with cirrhosis. It increases mortality in the setting of cirrhosis and may influence the frequency and severity. Initially the hypoxemia responds to low-flow supplemental oxygen, but over time, the need for oxygen supplementation is necessary. The liver transplantation is the only effective therapeutic option for its resolution. AIM: To update clinical manifestation, diagnosis and treatment of this entity. METHOD: A literature review was performed on management of hepatopulmonary syndrome. The electronic search was held of the Medline-PubMed, in English crossing the headings "hepatopulmonary syndrome", "liver transplantation" and "surgery". The search was completed in September 2013. RESULTS: Hepatopulmonary syndrome is classically defined by a widened alveolar-arterial oxygen gradient (AaPO2) on room air (>15 mmHg, or >20 mmHg in patients >64 years of age) with or without hypoxemia resulting from intrapulmonary vasodilatation in the presence of hepatic dysfunction or portal hypertension. Clinical manifestation, diagnosis, classification, treatments and outcomes are varied. CONCLUSION: The severity of hepatopulmonary syndrome is an important survival predictor and determine the improvement, the time and risks for liver transplantation. The liver transplantation still remains the only effective therapeutic.
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spelling The hepatopulmonary syndromeHepatopulmonary syndromeLiver transplantationSurgery INTRODUCTION: The hepatopulmonary syndrome has been acknowledged as an important vascular complication in lungs developing systemic hypoxemia in patients with cirrhosis and portal hypertension. Is formed by arterial oxygenation abnormalities induced from intrapulmonary vascular dilatations with liver disease. It is present in 4-32% of patients with cirrhosis. It increases mortality in the setting of cirrhosis and may influence the frequency and severity. Initially the hypoxemia responds to low-flow supplemental oxygen, but over time, the need for oxygen supplementation is necessary. The liver transplantation is the only effective therapeutic option for its resolution. AIM: To update clinical manifestation, diagnosis and treatment of this entity. METHOD: A literature review was performed on management of hepatopulmonary syndrome. The electronic search was held of the Medline-PubMed, in English crossing the headings "hepatopulmonary syndrome", "liver transplantation" and "surgery". The search was completed in September 2013. RESULTS: Hepatopulmonary syndrome is classically defined by a widened alveolar-arterial oxygen gradient (AaPO2) on room air (>15 mmHg, or >20 mmHg in patients >64 years of age) with or without hypoxemia resulting from intrapulmonary vasodilatation in the presence of hepatic dysfunction or portal hypertension. Clinical manifestation, diagnosis, classification, treatments and outcomes are varied. CONCLUSION: The severity of hepatopulmonary syndrome is an important survival predictor and determine the improvement, the time and risks for liver transplantation. The liver transplantation still remains the only effective therapeutic. Colégio Brasileiro de Cirurgia Digestiva2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202014000200145ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.27 n.2 2014reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD)instacron:CBCD10.1590/S0102-67202014000200012info:eu-repo/semantics/openAccessNACIF,Lucas SoutoANDRAUS,WellingtonPINHEIRO,Rafael SoaresDUCATTI,LilianaHADDAD,Luciana BPD'ALBUQUERQUE,Luiz Carneiroeng2015-07-27T00:00:00Zoai:scielo:S0102-67202014000200145Revistahttp://abarriguda.org.br/revista/index.php/revistaabarrigudaarepb/indexONGhttps://old.scielo.br/oai/scielo-oai.php||revistaabcd@gmail.com2317-63262317-6326opendoar:2015-07-27T00:00ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD)false
dc.title.none.fl_str_mv The hepatopulmonary syndrome
title The hepatopulmonary syndrome
spellingShingle The hepatopulmonary syndrome
NACIF,Lucas Souto
Hepatopulmonary syndrome
Liver transplantation
Surgery
title_short The hepatopulmonary syndrome
title_full The hepatopulmonary syndrome
title_fullStr The hepatopulmonary syndrome
title_full_unstemmed The hepatopulmonary syndrome
title_sort The hepatopulmonary syndrome
author NACIF,Lucas Souto
author_facet NACIF,Lucas Souto
ANDRAUS,Wellington
PINHEIRO,Rafael Soares
DUCATTI,Liliana
HADDAD,Luciana BP
D'ALBUQUERQUE,Luiz Carneiro
author_role author
author2 ANDRAUS,Wellington
PINHEIRO,Rafael Soares
DUCATTI,Liliana
HADDAD,Luciana BP
D'ALBUQUERQUE,Luiz Carneiro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv NACIF,Lucas Souto
ANDRAUS,Wellington
PINHEIRO,Rafael Soares
DUCATTI,Liliana
HADDAD,Luciana BP
D'ALBUQUERQUE,Luiz Carneiro
dc.subject.por.fl_str_mv Hepatopulmonary syndrome
Liver transplantation
Surgery
topic Hepatopulmonary syndrome
Liver transplantation
Surgery
description INTRODUCTION: The hepatopulmonary syndrome has been acknowledged as an important vascular complication in lungs developing systemic hypoxemia in patients with cirrhosis and portal hypertension. Is formed by arterial oxygenation abnormalities induced from intrapulmonary vascular dilatations with liver disease. It is present in 4-32% of patients with cirrhosis. It increases mortality in the setting of cirrhosis and may influence the frequency and severity. Initially the hypoxemia responds to low-flow supplemental oxygen, but over time, the need for oxygen supplementation is necessary. The liver transplantation is the only effective therapeutic option for its resolution. AIM: To update clinical manifestation, diagnosis and treatment of this entity. METHOD: A literature review was performed on management of hepatopulmonary syndrome. The electronic search was held of the Medline-PubMed, in English crossing the headings "hepatopulmonary syndrome", "liver transplantation" and "surgery". The search was completed in September 2013. RESULTS: Hepatopulmonary syndrome is classically defined by a widened alveolar-arterial oxygen gradient (AaPO2) on room air (>15 mmHg, or >20 mmHg in patients >64 years of age) with or without hypoxemia resulting from intrapulmonary vasodilatation in the presence of hepatic dysfunction or portal hypertension. Clinical manifestation, diagnosis, classification, treatments and outcomes are varied. CONCLUSION: The severity of hepatopulmonary syndrome is an important survival predictor and determine the improvement, the time and risks for liver transplantation. The liver transplantation still remains the only effective therapeutic.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202014000200145
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0102-67202014000200012
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dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgia Digestiva
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgia Digestiva
dc.source.none.fl_str_mv ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.27 n.2 2014
reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
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