Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000400256 |
Resumo: | A 4 year-old girl with bilateral, non-familial retinoblastoma (RB) was referred to our care after primary enucleation OS and active tumor OD refractory to multiple therapies (intravenous chemotherapy, laser/cryotherapy, and I-125 plaque radiotherapy). Vitreous seeding OD, initially controlled by several sessions of Ophthalmic Artery Infusion Chemotherapy (OAIC) and periocular chemotherapy, recurred shortly thereafter. The patient underwent intravitreal (IVit) Melphalan injections achieving tumor control despite the concurrent development of keratopathy, pupillary synechiae, cataract, and necrosis of the inferior fornix and the adjacent orbital fat, all secondary to the treatments administered. Repeated amniotic membrane implants and tarsorrhaphy were performed to alleviate the symptoms. Despite being tumor free for 6 months, a poor fundus view and treatment-related complications prompted us to consider enucleation, but parents declined. Following recent negative magnetic resonance imaging (MRI), her cataract was removed. She was then found to have tumor recurrence. Her eye was enucleated 12 months ago and she recovered well from the surgery. As ocular oncology embarks in eye-preserving treatments for retinoblastoma, it is important to address the cumulative effects and associated impact of such treatments and the possibility of failure. |
id |
CBO-2_e58602c7277b99ac9ccc6948fd9ec2af |
---|---|
oai_identifier_str |
oai:scielo:S0004-27492014000400256 |
network_acronym_str |
CBO-2 |
network_name_str |
Arquivos brasileiros de oftalmologia (Online) |
repository_id_str |
|
spelling |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seedingRetinoblastoma/drug therapyRetinoblastoma/surgeryMelphalan/administration & dosageVitreous body/pathologyIntravitreal injectionsRetinal neoplasms/surgeryEye enucleationHumansFemaleChildCase reportsA 4 year-old girl with bilateral, non-familial retinoblastoma (RB) was referred to our care after primary enucleation OS and active tumor OD refractory to multiple therapies (intravenous chemotherapy, laser/cryotherapy, and I-125 plaque radiotherapy). Vitreous seeding OD, initially controlled by several sessions of Ophthalmic Artery Infusion Chemotherapy (OAIC) and periocular chemotherapy, recurred shortly thereafter. The patient underwent intravitreal (IVit) Melphalan injections achieving tumor control despite the concurrent development of keratopathy, pupillary synechiae, cataract, and necrosis of the inferior fornix and the adjacent orbital fat, all secondary to the treatments administered. Repeated amniotic membrane implants and tarsorrhaphy were performed to alleviate the symptoms. Despite being tumor free for 6 months, a poor fundus view and treatment-related complications prompted us to consider enucleation, but parents declined. Following recent negative magnetic resonance imaging (MRI), her cataract was removed. She was then found to have tumor recurrence. Her eye was enucleated 12 months ago and she recovered well from the surgery. As ocular oncology embarks in eye-preserving treatments for retinoblastoma, it is important to address the cumulative effects and associated impact of such treatments and the possibility of failure.Conselho Brasileiro de Oftalmologia2014-08-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000400256Arquivos Brasileiros de Oftalmologia v.77 n.4 2014reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20140064info:eu-repo/semantics/openAccessBrink,AubreyCorrea,Zélia MariaGeller,JamesAbruzzo,ToddAugsburger,James J.eng2014-11-13T00:00:00Zoai:scielo:S0004-27492014000400256Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2014-11-13T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
title |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
spellingShingle |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding Brink,Aubrey Retinoblastoma/drug therapy Retinoblastoma/surgery Melphalan/administration & dosage Vitreous body/pathology Intravitreal injections Retinal neoplasms/surgery Eye enucleation Humans Female Child Case reports |
title_short |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
title_full |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
title_fullStr |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
title_full_unstemmed |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
title_sort |
Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding |
author |
Brink,Aubrey |
author_facet |
Brink,Aubrey Correa,Zélia Maria Geller,James Abruzzo,Todd Augsburger,James J. |
author_role |
author |
author2 |
Correa,Zélia Maria Geller,James Abruzzo,Todd Augsburger,James J. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Brink,Aubrey Correa,Zélia Maria Geller,James Abruzzo,Todd Augsburger,James J. |
dc.subject.por.fl_str_mv |
Retinoblastoma/drug therapy Retinoblastoma/surgery Melphalan/administration & dosage Vitreous body/pathology Intravitreal injections Retinal neoplasms/surgery Eye enucleation Humans Female Child Case reports |
topic |
Retinoblastoma/drug therapy Retinoblastoma/surgery Melphalan/administration & dosage Vitreous body/pathology Intravitreal injections Retinal neoplasms/surgery Eye enucleation Humans Female Child Case reports |
description |
A 4 year-old girl with bilateral, non-familial retinoblastoma (RB) was referred to our care after primary enucleation OS and active tumor OD refractory to multiple therapies (intravenous chemotherapy, laser/cryotherapy, and I-125 plaque radiotherapy). Vitreous seeding OD, initially controlled by several sessions of Ophthalmic Artery Infusion Chemotherapy (OAIC) and periocular chemotherapy, recurred shortly thereafter. The patient underwent intravitreal (IVit) Melphalan injections achieving tumor control despite the concurrent development of keratopathy, pupillary synechiae, cataract, and necrosis of the inferior fornix and the adjacent orbital fat, all secondary to the treatments administered. Repeated amniotic membrane implants and tarsorrhaphy were performed to alleviate the symptoms. Despite being tumor free for 6 months, a poor fundus view and treatment-related complications prompted us to consider enucleation, but parents declined. Following recent negative magnetic resonance imaging (MRI), her cataract was removed. She was then found to have tumor recurrence. Her eye was enucleated 12 months ago and she recovered well from the surgery. As ocular oncology embarks in eye-preserving treatments for retinoblastoma, it is important to address the cumulative effects and associated impact of such treatments and the possibility of failure. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000400256 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000400256 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0004-2749.20140064 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.77 n.4 2014 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209028173463552 |