Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Baiak,Barbara Haline Buss
Data de Publicação: 2019
Outros Autores: Lehnen,Cheila Roberta, Rocha,Raquel Abdallah da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000100059
Resumo: Abstract The purpose of this work was to identify, critically assess, and summarize available data from primary research about the anthelmintic resistance of injectable macrocyclic lactones in cattle. Meta-analysis was performed to estimate the pooled Odds Ratio and 95% Confidence Intervals. Of the 1504 abstracts screened for eligibility, 80 were deemed relevant for full publication review. Thirteen publications were included in the qualitative synthesis and assessed for systematic bias. Only five studies were included in the quantitative analysis because they showed a low risk of producing biased results in all the parameters. The forest plot indicated four studies that discuss anthelmintic resistance (P<0.05), while only one study did not discuss anthelmintic resistance (P<0.05). The pooled estimate showed 0.59 (95% Confidence intervals: 0.08, 0.47) times higher odds for studies that report anthelmintic resistance than for studies reporting efficacious anthelmintic treatment, with significant and substantially low heterogeneity (I2=25%). Anthelmintic resistance to injectable macrocyclic lactones is a reality. There are need to improve methodological reporting in studies, which is a problem for investigations that involves systematic review and meta-analysis (SR-MA).
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spelling Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysisAnthelmintic drugsnematodesivermectinmoxidectinAbstract The purpose of this work was to identify, critically assess, and summarize available data from primary research about the anthelmintic resistance of injectable macrocyclic lactones in cattle. Meta-analysis was performed to estimate the pooled Odds Ratio and 95% Confidence Intervals. Of the 1504 abstracts screened for eligibility, 80 were deemed relevant for full publication review. Thirteen publications were included in the qualitative synthesis and assessed for systematic bias. Only five studies were included in the quantitative analysis because they showed a low risk of producing biased results in all the parameters. The forest plot indicated four studies that discuss anthelmintic resistance (P<0.05), while only one study did not discuss anthelmintic resistance (P<0.05). The pooled estimate showed 0.59 (95% Confidence intervals: 0.08, 0.47) times higher odds for studies that report anthelmintic resistance than for studies reporting efficacious anthelmintic treatment, with significant and substantially low heterogeneity (I2=25%). Anthelmintic resistance to injectable macrocyclic lactones is a reality. There are need to improve methodological reporting in studies, which is a problem for investigations that involves systematic review and meta-analysis (SR-MA).Colégio Brasileiro de Parasitologia Veterinária2019-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000100059Revista Brasileira de Parasitologia Veterinária v.28 n.1 2019reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/s1984-296120180093info:eu-repo/semantics/openAccessBaiak,Barbara Haline BussLehnen,Cheila RobertaRocha,Raquel Abdallah daeng2020-01-28T00:00:00Zoai:scielo:S1984-29612019000100059Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2020-01-28T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false
dc.title.none.fl_str_mv Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
title Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
spellingShingle Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
Baiak,Barbara Haline Buss
Anthelmintic drugs
nematodes
ivermectin
moxidectin
title_short Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
title_full Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
title_fullStr Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
title_full_unstemmed Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
title_sort Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis
author Baiak,Barbara Haline Buss
author_facet Baiak,Barbara Haline Buss
Lehnen,Cheila Roberta
Rocha,Raquel Abdallah da
author_role author
author2 Lehnen,Cheila Roberta
Rocha,Raquel Abdallah da
author2_role author
author
dc.contributor.author.fl_str_mv Baiak,Barbara Haline Buss
Lehnen,Cheila Roberta
Rocha,Raquel Abdallah da
dc.subject.por.fl_str_mv Anthelmintic drugs
nematodes
ivermectin
moxidectin
topic Anthelmintic drugs
nematodes
ivermectin
moxidectin
description Abstract The purpose of this work was to identify, critically assess, and summarize available data from primary research about the anthelmintic resistance of injectable macrocyclic lactones in cattle. Meta-analysis was performed to estimate the pooled Odds Ratio and 95% Confidence Intervals. Of the 1504 abstracts screened for eligibility, 80 were deemed relevant for full publication review. Thirteen publications were included in the qualitative synthesis and assessed for systematic bias. Only five studies were included in the quantitative analysis because they showed a low risk of producing biased results in all the parameters. The forest plot indicated four studies that discuss anthelmintic resistance (P<0.05), while only one study did not discuss anthelmintic resistance (P<0.05). The pooled estimate showed 0.59 (95% Confidence intervals: 0.08, 0.47) times higher odds for studies that report anthelmintic resistance than for studies reporting efficacious anthelmintic treatment, with significant and substantially low heterogeneity (I2=25%). Anthelmintic resistance to injectable macrocyclic lactones is a reality. There are need to improve methodological reporting in studies, which is a problem for investigations that involves systematic review and meta-analysis (SR-MA).
publishDate 2019
dc.date.none.fl_str_mv 2019-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000100059
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000100059
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1984-296120180093
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dc.publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
dc.source.none.fl_str_mv Revista Brasileira de Parasitologia Veterinária v.28 n.1 2019
reponame:Revista Brasileira de Parasitologia Veterinária (Online)
instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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instname_str Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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reponame_str Revista Brasileira de Parasitologia Veterinária (Online)
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