Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country

Detalhes bibliográficos
Autor(a) principal: Silva, Patrícia Santiago
Data de Publicação: 2014
Outros Autores: Grinsztejn, Beatriz, Friedman, Ruth Khalili, Cunha, Cynthia Braga da Cunha, Coelho, Lara Esteves, Luz, Paula Mendes, Oliveira, Albanita Viana de, Moreira, Ronaldo Ismério, Cardoso, Sandra Wagner, Santos, Valdiléa Gonçalves Veloso dos, Suassuna, José Hermógenes Rocco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10284
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Patrícia SantiagoGrinsztejn, BeatrizFriedman, Ruth KhaliliCunha, Cynthia Braga da CunhaCoelho, Lara EstevesLuz, Paula MendesOliveira, Albanita Viana deMoreira, Ronaldo IsmérioCardoso, Sandra WagnerSantos, Valdiléa Gonçalves Veloso dosSuassuna, José Hermógenes Rocco2015-05-11T18:07:25Z2015-05-11T18:07:25Z2014SILVA, Patrícia Santiago et al. Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country. Plos One, v. 9, n. 4, p. 1-7, Apr. 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1028410.1371/journal.pone.00937481932-6203engPublic Library of ScienceScreening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income countryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasiFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.With the introduction of combined active antiretroviral therapy and the improved survival of HIV-infected patients, degenerative diseases and drug toxicity have emerged as long-term concerns. We studied the prevalence of decreased glomerular filtration rate (GFR) and associated risk factors in a cohort of HIV-infected patients from a middle-income country. Our cross-sectional study included all adult patients who attended an urban outpatient clinic in 2008. GFR was estimated using the CKD-EPI equation. The prevalence ratio (PR) of decreased GFR (defined as ,60 mL/min/1.73 m2) was estimated using generalizing linear models assuming a Poisson distribution. We analyzed data from 1,970 patients, of which 82.9% had been exposed to ART. A total of 249 patients (12.6%) had a GFR between 60 and 89 mL/min/1.73 m2, 3.1% had a GFR between 30 and 59, 0.3% had a GFR between 15 and 29, and 0.4% had a GFR ,15. Decreased GFR was found in only 74 patients (3.8%). In the multivariate regression model, the factors that were independently associated with a GFR below 60 mL/min/1.73 m2 were as follows: age $50 years (PR = 3.4; 95% CI: 1.7–6.8), diabetes (PR = 2.0; 95% CI: 1.2–3.4), hypertension (PR = 2.0; 95% CI: 1.3–3.2), current CD4+ cell count ,350 cells/mm3 (PR = 2.1; 95% CI: 1.3–3.3), past exposure to tenofovir (PR = 4.7; 95% CI: 2.3–9.4) and past exposure to indinavir (PR = 1.7; 95% CI: 1.0–2.8). As in high-income countries, CKD was the predominant form of kidney involvement among HIV-infected individuals in our setting. The risk factors associated with decreased glomerular filtration were broad and included virus-related factors as well as degenerative and nephrotoxic factors. Despite the potential for nephrotoxicity associated with some antiretroviral drugs, in the short-term, advanced chronic renal disease remains very rare.Acquired Immunodeficiency SyndromeGlomerular filtration rateHighly active antiretroviral therapyStatistical analysisSíndrome de Imunodeficiência AdquiridaTaxa de filtração glomerularTerapia antirretroviral de alta atividadeAnálise estatísticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10284/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALScreening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country.pdfScreening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income 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dc.title.pt_BR.fl_str_mv Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
title Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
spellingShingle Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
Silva, Patrícia Santiago
Acquired Immunodeficiency Syndrome
Glomerular filtration rate
Highly active antiretroviral therapy
Statistical analysis
Síndrome de Imunodeficiência Adquirida
Taxa de filtração glomerular
Terapia antirretroviral de alta atividade
Análise estatística
title_short Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
title_full Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
title_fullStr Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
title_full_unstemmed Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
title_sort Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country
author Silva, Patrícia Santiago
author_facet Silva, Patrícia Santiago
Grinsztejn, Beatriz
Friedman, Ruth Khalili
Cunha, Cynthia Braga da Cunha
Coelho, Lara Esteves
Luz, Paula Mendes
Oliveira, Albanita Viana de
Moreira, Ronaldo Ismério
Cardoso, Sandra Wagner
Santos, Valdiléa Gonçalves Veloso dos
Suassuna, José Hermógenes Rocco
author_role author
author2 Grinsztejn, Beatriz
Friedman, Ruth Khalili
Cunha, Cynthia Braga da Cunha
Coelho, Lara Esteves
Luz, Paula Mendes
Oliveira, Albanita Viana de
Moreira, Ronaldo Ismério
Cardoso, Sandra Wagner
Santos, Valdiléa Gonçalves Veloso dos
Suassuna, José Hermógenes Rocco
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Patrícia Santiago
Grinsztejn, Beatriz
Friedman, Ruth Khalili
Cunha, Cynthia Braga da Cunha
Coelho, Lara Esteves
Luz, Paula Mendes
Oliveira, Albanita Viana de
Moreira, Ronaldo Ismério
Cardoso, Sandra Wagner
Santos, Valdiléa Gonçalves Veloso dos
Suassuna, José Hermógenes Rocco
dc.subject.en.pt_BR.fl_str_mv Acquired Immunodeficiency Syndrome
Glomerular filtration rate
Highly active antiretroviral therapy
Statistical analysis
topic Acquired Immunodeficiency Syndrome
Glomerular filtration rate
Highly active antiretroviral therapy
Statistical analysis
Síndrome de Imunodeficiência Adquirida
Taxa de filtração glomerular
Terapia antirretroviral de alta atividade
Análise estatística
dc.subject.decs.pt_BR.fl_str_mv Síndrome de Imunodeficiência Adquirida
Taxa de filtração glomerular
Terapia antirretroviral de alta atividade
Análise estatística
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-11T18:07:25Z
dc.date.available.fl_str_mv 2015-05-11T18:07:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Patrícia Santiago et al. Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country. Plos One, v. 9, n. 4, p. 1-7, Apr. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10284
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0093748
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv SILVA, Patrícia Santiago et al. Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country. Plos One, v. 9, n. 4, p. 1-7, Apr. 2014.
1932-6203
10.1371/journal.pone.0093748
url https://www.arca.fiocruz.br/handle/icict/10284
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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