Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry

Detalhes bibliográficos
Autor(a) principal: Cantú-Brito, Carlos
Data de Publicação: 2012
Outros Autores: Chiquete, Erwin, Ruiz-Sandoval, José L., Gaxiola, Efraín, Albuquerque, Denilson C., Corbalán, Ramón, Ramos, Alma, Bhatt, Deepak L., Steg, P. Gabriel, REACH Latin America Collaborative Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36451
Resumo: Sérgio Salles Xavier. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Cantú-Brito, CarlosChiquete, ErwinRuiz-Sandoval, José L.Gaxiola, EfraínAlbuquerque, Denilson C.Corbalán, RamónRamos, AlmaBhatt, Deepak L.Steg, P. GabrielREACH Latin America Collaborative Group2019-10-15T14:46:18Z2019-10-15T14:46:18Z2012CANTÚ-BRITO, Carlos et al. Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH Registry. Clinical Cardiology, v. 35, n. 8, p. 451-457, 2012.0160-9289https://www.arca.fiocruz.br/handle/icict/3645110.1002/clc.220051932-8737Sérgio Salles Xavier. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.REACH Investigators by Country: Chile: Acevedo M, Araya F, Barrientos N, Blanchi V, Chavez E, Corbalan R, Diaz R, Dighero H, Garayar B, Garjardo L, ´Garrido B, Gutierrez V, Hoppe A, Kauffmann R, Kramer A, Kunstmann S, Manriquez L, Srur EM, Tapia J, Varleta PE, Villar RA. Panama: Arango AC, Arauz J, Benzadon A, Cabrera JR, Cantisano L, Castillo B, Chavez EH, Chen CH, Diaz E, Dina RE, Espinosa H, Hernandez D, Hernandez J, Lopez R, Madrid JL, Medine FP, Minchola JA, Mini M, Molina G, Motta J, Moya J, Ortiz ME, Parajeles A, Ramos CA, Rodriguez E, Saravia GL, Sprok JM, Tortos-Guzman J, Urrutia V, Veras D, Vercauteren JP, Villa-Garcin P, Vinocour M. Brazil: Albuquerque D, Atai de Jr L, Atie J, Avezum A, Bandeira F, Bodanese L, Brasileiro A, Carvalho AC, Dutra O, Esporcatte R, Esteves JP, Eugenio AM, Feitosa G, Fernandes J, Halpern A, Knobel M, Lopes C, Lyra R, Machado N, Maciel L, Marino R, Massaro A, Matos A, Mesquita E, Moreira M, Nagato YN, Nicolau JC, Nogueira PR, Pazin-Filho A, Pires MT, Rocha A, Rocha R, Saraiva JF, Schmid H, Serro J, Tambascia M, Xavier SS, Yamamoto F, Yoshida WB, Zanella MT. Mexico: Abundes A, Aguayo G, Alcocer MA, Alegr´ıa MA, Alexanderson G, Alpizar M, Amaya LE, Arauz A, Astorga A, Azpiri JR, Barinagarrementeria F, Benavides MA, Bernal E, Briseno HM, Caluo C, Cant ˜ u-Brito C, Cedillo FR, Colorado ´H, Cortes J, Cossio J, De los R´ıos MO, De Zatarain R, D´ıaz C, Eng L, Esparragoza J, Espinosa L, Espinoza C, Fernandez P, Garc´ıa E, Garc´ıa R, Garza A, Gaxiola E, Gonzalez FJ, Guerrero F, Herududez I, Kostine A, Leiva JL, Llamas-Lopez L, Lopez B, L ´ opez J, L ´ opez M, Marcos A, Najar S, Nettel J, Ortiz F, Peralta R, Perez JC, Ranero A, Rangel-Guerra R, Rodr´ıguez J, Rodr´ıguez L, Rojas JA, Romero A, Rubio G, Ruiz JL, Sagastegui A, Talamas O, Tapia M, Toriz JL, Uribe A, Vazquez J, Velasco JA, Velasco EC, Velasco-Sanchez RG, Villarreal J.Salvador Zubirán National Institute of Medical Sciences and Nutrition. Department of Neurology and Psychiatry Mexico City, Mexico.Salvador Zubirán National Institute of Medical Sciences and Nutrition. Department of Neurology and Psychiatry Mexico City, Mexico.Fray Antonio Alcalde Public Hospital. Department of Neurology. Guadalajara, Jalisco, Mexico.Jardines Specialty Hospital. Department of Cardiology. Zapopan, Jalisco, Mexico.State University of Rio de Janeiro. Hospital Pedro Ernesto. Department of Cardiology. Rio de Janeiro, RJ, Brasil.Pontifical Catholic University of Chile. Department of Cardiovascular Diseases. Santiago de Chile, Chile.Scientific Department. Clinical Research Department. Sanofi, Mexico.VA Boston Healthcare System. Brigham and Women’s Hospital. Department of Cardiology. Boston, MA, USA / Harvard Medical School. Boston, MA, USA.Bichat-Claude Bernard Hospital. Paris, France / University Hospital North Paris Val de Seine. Paris, France / Paris Diderot University. Paris, France.Background: Atherothrombosis is becoming the leading cause of chronic morbidity in developing countries. This epidemiological transition will represent an unbearable socioeconomic burden in the near future. We investigated factors associated with 4-year all-cause mortality in a Latin American population at high risk. Hypothesis: Largely modifiable risk factors as well as polyvascular disease are the main predictors of 4-year all-cause and cardiovascular mortality in this Latin American cohort. Methods: We analyzed 1816 Latin American stable outpatients (62.3% men, mean age 67 years) with symptomatic atherothrombosis (87.1%) or with multiple risk factors only (12.9%), in the Reduction of Atherothrombosis for Continued Health registry. Results: Of patients with symptomatic atherothrombosis, 57.3% had coronary artery disease, 32% cerebrovascular disease, and 11.7% peripheral artery disease at baseline (9.1% polyvascular). The main risk factors were hypertension (76%), hypercholesterolemia (60%), and smoking (52.3%) in patients with established atherothrombosis; and hypertension (89.7%), diabetes (80.8%), and hypercholesterolemia (73.9%) in those with risk factors only. Four-year all-cause mortality steeply increased with none (6.8%), 1 (9.2%), 2 (15.5%), and 3 (29.2%) symptomatic arterial disease locations. In patients with only 1 location, cardiovascular mortality was significantly higher with peripheral artery disease (11.3%) than with cerebrovascular disease (6%) or coronary artery disease (5.1%). Significant baseline predictors of 4-year all-cause mortality were congestive heartfailure (hazard ratio [HR]: 3.81), body mass index<20 (HR: 2.32), hypertension (HR: 1.84), polyvascular disease (HR: 1.69), and age ≥65 years (HR: 1.47), whereas statin use (HR: 0.49) and body mass index ≥30 (HR: 0.58) were associated with a reduced risk. Conclusions: Hypertension was the main modifiable risk factor for atherothrombosis and all-cause mortality in this Latin American cohort. Nearly one-third of the population with 3 symptomatic vascular-disease locations died at 4-year follow-up.engWiley Open AccessAtherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAtherothrombotic diseaseRisk factorsMortalityLatin Americaninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36451/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cantu-Brito_Carlos_etal_INI_2012.pdfve_Cantu-Brito_Carlos_etal_INI_2012.pdfapplication/pdf274833https://www.arca.fiocruz.br/bitstream/icict/36451/2/ve_Cantu-Brito_Carlos_etal_INI_2012.pdfd72c0b6da13433fa50bf9e204cb83cdeMD52TEXTve_Cantu-Brito_Carlos_etal_INI_2012.pdf.txtve_Cantu-Brito_Carlos_etal_INI_2012.pdf.txtExtracted texttext/plain39412https://www.arca.fiocruz.br/bitstream/icict/36451/3/ve_Cantu-Brito_Carlos_etal_INI_2012.pdf.txtaa6be4e048065595f5b3904bfa5c94c2MD53icict/364512019-10-16 02:01:47.81oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-16T05:01:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
title Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
spellingShingle Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
Cantú-Brito, Carlos
Atherothrombotic disease
Risk factors
Mortality
Latin American
title_short Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
title_full Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
title_fullStr Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
title_full_unstemmed Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
title_sort Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH registry
author Cantú-Brito, Carlos
author_facet Cantú-Brito, Carlos
Chiquete, Erwin
Ruiz-Sandoval, José L.
Gaxiola, Efraín
Albuquerque, Denilson C.
Corbalán, Ramón
Ramos, Alma
Bhatt, Deepak L.
Steg, P. Gabriel
REACH Latin America Collaborative Group
author_role author
author2 Chiquete, Erwin
Ruiz-Sandoval, José L.
Gaxiola, Efraín
Albuquerque, Denilson C.
Corbalán, Ramón
Ramos, Alma
Bhatt, Deepak L.
Steg, P. Gabriel
REACH Latin America Collaborative Group
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cantú-Brito, Carlos
Chiquete, Erwin
Ruiz-Sandoval, José L.
Gaxiola, Efraín
Albuquerque, Denilson C.
Corbalán, Ramón
Ramos, Alma
Bhatt, Deepak L.
Steg, P. Gabriel
REACH Latin America Collaborative Group
dc.subject.en.pt_BR.fl_str_mv Atherothrombotic disease
Risk factors
Mortality
Latin American
topic Atherothrombotic disease
Risk factors
Mortality
Latin American
description Sérgio Salles Xavier. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-15T14:46:18Z
dc.date.available.fl_str_mv 2019-10-15T14:46:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CANTÚ-BRITO, Carlos et al. Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH Registry. Clinical Cardiology, v. 35, n. 8, p. 451-457, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36451
dc.identifier.issn.pt_BR.fl_str_mv 0160-9289
dc.identifier.doi.none.fl_str_mv 10.1002/clc.22005
dc.identifier.eissn.none.fl_str_mv 1932-8737
identifier_str_mv CANTÚ-BRITO, Carlos et al. Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH Registry. Clinical Cardiology, v. 35, n. 8, p. 451-457, 2012.
0160-9289
10.1002/clc.22005
1932-8737
url https://www.arca.fiocruz.br/handle/icict/36451
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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