Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Katz, Naftale
Data de Publicação: 2017
Outros Autores: Araújo, Neusa, Coelho, Paulo Marcos Zech, Morel, Carlos Medicis, Linde-Arias, Ana Rosa, Yamada, Takeshi, Horimatsu, Yuki, Suzuki, Koh, Sunazuka, Toshiaki, Omura, Satoshi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19431
Resumo: 2017-09-15
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spelling Katz, NaftaleAraújo, NeusaCoelho, Paulo Marcos ZechMorel, Carlos MedicisLinde-Arias, Ana RosaYamada, TakeshiHorimatsu, YukiSuzuki, KohSunazuka, ToshiakiOmura, Satoshi2017-06-20T13:21:58Z2017-06-20T13:21:58Z2017Katz, N. et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. The Journal of Antibiotics, v. 70, p. 680–684, 2017.0021-8820https://www.arca.fiocruz.br/handle/icict/1943110.1038/ja.2017.311881-1469engJapan Antibiotics Research Association eBiomphalariaIvermectinaEsquistossomoseBiomphalariaIvermectinSchistosomiasisIvermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2017-09-15Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas, Rio de Janeiro, RJ, Brasil.Kitasato University. Kitasato Institute for Life Sciences. Tokyo, Japan / Kitasato University. Graduate School of Infection Control Sciences. Tokyo, Japan.Kitasato University. Graduate School of Infection Control Sciences. Tokyo, Japan.Kitasato University. Graduate School of Infection Control Sciences. Tokyo, Japan.Kitasato University. Kitasato Institute for Life Sciences. Tokyo, Japan / Kitasato University. Graduate School of Infection Control Sciences. Tokyo, Japan.Kitasato University. Kitasato Institute for Life Sciences. Tokyo, JapanThe impact of ivermectin on adult snails of the genus Biomphalaria (B. glabrata, B. tenagophila and B. straminea), B. glabrata infected with Schistosoma mansoni, snail egg-masses cercariae and miracidia, as well as on guppy fish (Poecilia reticulata) was examined and evaluated. Biomphalaria snails, egg-masses, parasite stages and guppies were all exposed to different concentrations of ivermectin for 24 h, followed by regular observations of mortality. The calculated lethal doses of ivermectin were around an LD50 of 0.03 μg ml − 1, and an LD90 of 0.3 μg ml − 1 for the three species of snails. Specimens of B. glabrata actually shedding parasite cercariae all died when exposed to ivermectin at a concentration of a mere 0.01 μg ml − 1. Ivermectin B1a, the major (80%) component of commercially available ivermectin, proved to be inactive, and it was the minor (20%) component, ivermectin B1b, which caused snail death. Snail egg-masses were not affected, even at the highest concentration of 100 μg ml − 1. With respect to S. mansoni parasite stages, 0.2 μg ml − 1 ivermectin killed 50% of cercariae and miracidia within five minutes, rising to 90% after 30 min. Mortality of guppy fish within 24 h of exposure to ivermectin at concentrations of 0.5 μg ml − 1 and 0.01 μg ml − 1, were 100% and 30%, respectively. The concentration of 0.01 μg ml − 1 that killed Schistosoma mansoni-infected snails only caused 30% mortality in guppy fish. Ivermectin can be considered a promising molluscicide, Especially as it is more potent against infected snails than uninfected ones, although it has no impact on egg-masses. Ivermectin and its derivatives could be explored in the search for a new agent to help control schistosomiasis transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19431/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALja201731a.pdfja201731a.pdfapplication/pdf239291https://www.arca.fiocruz.br/bitstream/icict/19431/2/ja201731a.pdf33eb306d1a5a9192fed226e3a5775bfaMD52TEXTja201731a.pdf.txtja201731a.pdf.txtExtracted texttext/plain30713https://www.arca.fiocruz.br/bitstream/icict/19431/3/ja201731a.pdf.txt98a9b1df5e29c444b06d82702d310268MD53icict/194312023-01-27 14:53:36.317oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-01-27T17:53:36Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
title Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
spellingShingle Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
Katz, Naftale
Biomphalaria
Ivermectina
Esquistossomose
Biomphalaria
Ivermectin
Schistosomiasis
title_short Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
title_full Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
title_fullStr Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
title_full_unstemmed Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
title_sort Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
author Katz, Naftale
author_facet Katz, Naftale
Araújo, Neusa
Coelho, Paulo Marcos Zech
Morel, Carlos Medicis
Linde-Arias, Ana Rosa
Yamada, Takeshi
Horimatsu, Yuki
Suzuki, Koh
Sunazuka, Toshiaki
Omura, Satoshi
author_role author
author2 Araújo, Neusa
Coelho, Paulo Marcos Zech
Morel, Carlos Medicis
Linde-Arias, Ana Rosa
Yamada, Takeshi
Horimatsu, Yuki
Suzuki, Koh
Sunazuka, Toshiaki
Omura, Satoshi
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Katz, Naftale
Araújo, Neusa
Coelho, Paulo Marcos Zech
Morel, Carlos Medicis
Linde-Arias, Ana Rosa
Yamada, Takeshi
Horimatsu, Yuki
Suzuki, Koh
Sunazuka, Toshiaki
Omura, Satoshi
dc.subject.other.pt_BR.fl_str_mv Biomphalaria
Ivermectina
Esquistossomose
topic Biomphalaria
Ivermectina
Esquistossomose
Biomphalaria
Ivermectin
Schistosomiasis
dc.subject.en.pt_BR.fl_str_mv Biomphalaria
Ivermectin
Schistosomiasis
description 2017-09-15
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-06-20T13:21:58Z
dc.date.available.fl_str_mv 2017-06-20T13:21:58Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Katz, N. et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. The Journal of Antibiotics, v. 70, p. 680–684, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19431
dc.identifier.issn.pt_BR.fl_str_mv 0021-8820
dc.identifier.doi.none.fl_str_mv 10.1038/ja.2017.31
dc.identifier.eissn.none.fl_str_mv 1881-1469
identifier_str_mv Katz, N. et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. The Journal of Antibiotics, v. 70, p. 680–684, 2017.
0021-8820
10.1038/ja.2017.31
1881-1469
url https://www.arca.fiocruz.br/handle/icict/19431
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Japan Antibiotics Research Association e
publisher.none.fl_str_mv Japan Antibiotics Research Association e
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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