One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Pereira, Christiane Costa
Data de Publicação: 2015
Outros Autores: Moreira, Marcela de Lima, Soares, Rodrigo Pedro Pinto, Marteleto, Bruno Henrique, Ribeiro, Vitor Marcio, Dias, Michelle Hallais França, Cardoso, Ludmila Melo, Viana, Kelvinson Fernandes, Giunchetti, Rodolfo Cordeiro, Martins Filho, Olindo Assis, Araújo, Márcio Sobreira Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12807
Resumo: Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
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spelling Pereira, Christiane CostaMoreira, Marcela de LimaSoares, Rodrigo Pedro PintoMarteleto, Bruno HenriqueRibeiro, Vitor MarcioDias, Michelle Hallais FrançaCardoso, Ludmila MeloViana, Kelvinson FernandesGiunchetti, Rodolfo CordeiroMartins Filho, Olindo AssisAraújo, Márcio Sobreira Silva2016-02-25T16:55:09Z2016-02-25T16:55:09Z2015PEREIRA, Christiane Costa et al. One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res., vol., 11, p. 92, 2015.1746-6148https://www.arca.fiocruz.br/handle/icict/1280710.1186/s12917-015-0397-6.engBioMed CentralOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilClínica Veterinária Santo Agostinho. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilBACKGROUND: The main control strategy for visceral leishmaniasis in Brazil has been based on the elimination of seropositive dogs, although this is not widely accepted. In this context, the use of a long-lasting protective vaccine against canine visceral leishmaniasis (CVL) has been highly expected. The aim of this work was to determine the timeline kinetics of the cytokine microenvironment derived from circulating leukocytes as supportive immunological biomarkers triggered by Leishmune® vaccine. Cross-sectional kinetic analysis of cellular immunity cytokines was carried out at three times (1, 6 and 12 months) after primovaccination with Leishmune®. In vitro short-term whole blood cultures were stimulated with Leishmania infantum soluble antigen (SLAg). The secreted cytokine signatures and their major sources were determined. RESULTS: At six months after vaccination, Leishmune® induced an increase in IL-8, IFN-γ, IL-17a and TNF-α levels and a decrease in IL-10. Cytokine signature analysis revealed a shift in the microenvironment towards a pro-inflammatory profile mediated by IL-8 and IFN-γ. Both, CD4(+) (↑TNF-α(+) and ↑IFN-γ (+)) and CD8(+) (↑IL-17a and ↓IL-4) T-cells contributed to the acquired immune responses observed after stimulation with SLAg. CONCLUSIONS: The changes observed in the cytokine profile suggested that Leishmune® was able to induce an effective response at six months after primovaccination. After one year, it returned to baseline suggesting the need of additional boosting.Canine visceral leishmaniasisVaccine, Leishmune®Cytokinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12807/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdfOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdfapplication/pdf6782061https://www.arca.fiocruz.br/bitstream/icict/12807/2/One-year%20timeline%20kinetics%20of%20cytokine-mediated%20cellular%20immunity%20in%20dogs%20vaccinated%20against%20visceral%20leishmaniasis.pdf77ecaad1e183d9a9a0d6c2c8d9d5bc69MD52TEXTOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdf.txtOne-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis.pdf.txtExtracted texttext/plain671https://www.arca.fiocruz.br/bitstream/icict/12807/3/One-year%20timeline%20kinetics%20of%20cytokine-mediated%20cellular%20immunity%20in%20dogs%20vaccinated%20against%20visceral%20leishmaniasis.pdf.txt8b57ae4697fe443ff95df68ffd3448aaMD53icict/128072022-02-02 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dc.title.pt_BR.fl_str_mv One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
title One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
spellingShingle One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
Pereira, Christiane Costa
Canine visceral leishmaniasis
Vaccine, Leishmune®
Cytokines
title_short One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
title_full One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
title_fullStr One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
title_full_unstemmed One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
title_sort One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis
author Pereira, Christiane Costa
author_facet Pereira, Christiane Costa
Moreira, Marcela de Lima
Soares, Rodrigo Pedro Pinto
Marteleto, Bruno Henrique
Ribeiro, Vitor Marcio
Dias, Michelle Hallais França
Cardoso, Ludmila Melo
Viana, Kelvinson Fernandes
Giunchetti, Rodolfo Cordeiro
Martins Filho, Olindo Assis
Araújo, Márcio Sobreira Silva
author_role author
author2 Moreira, Marcela de Lima
Soares, Rodrigo Pedro Pinto
Marteleto, Bruno Henrique
Ribeiro, Vitor Marcio
Dias, Michelle Hallais França
Cardoso, Ludmila Melo
Viana, Kelvinson Fernandes
Giunchetti, Rodolfo Cordeiro
Martins Filho, Olindo Assis
Araújo, Márcio Sobreira Silva
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Christiane Costa
Moreira, Marcela de Lima
Soares, Rodrigo Pedro Pinto
Marteleto, Bruno Henrique
Ribeiro, Vitor Marcio
Dias, Michelle Hallais França
Cardoso, Ludmila Melo
Viana, Kelvinson Fernandes
Giunchetti, Rodolfo Cordeiro
Martins Filho, Olindo Assis
Araújo, Márcio Sobreira Silva
dc.subject.en.pt_BR.fl_str_mv Canine visceral leishmaniasis
Vaccine, Leishmune®
Cytokines
topic Canine visceral leishmaniasis
Vaccine, Leishmune®
Cytokines
description Fundação Oswaldo Cruz. Centro Pesquisas René Rachou Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-02-25T16:55:09Z
dc.date.available.fl_str_mv 2016-02-25T16:55:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Christiane Costa et al. One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res., vol., 11, p. 92, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12807
dc.identifier.issn.none.fl_str_mv 1746-6148
dc.identifier.doi.none.fl_str_mv 10.1186/s12917-015-0397-6.
identifier_str_mv PEREIRA, Christiane Costa et al. One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis. BMC Vet Res., vol., 11, p. 92, 2015.
1746-6148
10.1186/s12917-015-0397-6.
url https://www.arca.fiocruz.br/handle/icict/12807
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/12807/2/One-year%20timeline%20kinetics%20of%20cytokine-mediated%20cellular%20immunity%20in%20dogs%20vaccinated%20against%20visceral%20leishmaniasis.pdf
https://www.arca.fiocruz.br/bitstream/icict/12807/3/One-year%20timeline%20kinetics%20of%20cytokine-mediated%20cellular%20immunity%20in%20dogs%20vaccinated%20against%20visceral%20leishmaniasis.pdf.txt
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