Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33690 |
Resumo: | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. |
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Espíndola, Milena SobralSoares, Luana SilvaLima, Leonardo Judson Galvão deZambuzi, Fabiana AlbaniCacemiro, Maira da CostaBrauer, Verônica SoaresMachado, Cleni Mara MarzocchiGomes, Matheus de SouzaAmaral, Laurence Rodrigues doMartins Filho, Olindo AssisBollela, Valdes RobertoFrantz, Fabiani Gai2019-06-27T16:57:54Z2019-06-27T16:57:54Z2018ESPÍNDOLA, Milena Sobral et al. Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection. Scientific Reports, v. 8, n. 1, 1-14, 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/3369010.1038/s41598-018-23841-1engNature Publishing GroupHIVHIVEpigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brasil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biomarcadores para Diagnostico e Monitoramento. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically in monocytes may contribute to the systemic immune dysfunction characterized by excessive immune activation in infected individuals, which directly correlates with pathogenesis and progression of the disease. Here, we investigated the immune dysfunction in monocytes from untreated and treated HIV + patients and associated these findings with epigenetic changes. Monocytes from HIV patients showed dysfunctional ability of phagocytosis and killing, and exhibited dysregulated cytokines and reactive oxygen species production after M. tuberculosis challenge in vitro. In addition, we showed that the expression of enzymes responsible for epigenetic changes was altered during HIV infection and was more prominent in patients that had high levels of soluble CD163 (sCD163), a newly identified plasmatic HIV progression biomarker. Among the enzymes, histone acetyltransferase 1 (HAT1) was the best epigenetic biomarker correlated with HIV - sCD163 high patients. In conclusion, we confirmed that HIV impairs effector functions of monocytes and these alterations are associated with epigenetic changes that once identified could be used as targets in therapies aiming the reduction of the systemic activation state found in HIV patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/33690/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALEpigenetic alterations are associated.pdfEpigenetic alterations are associated.pdfapplication/pdf2714750https://www.arca.fiocruz.br/bitstream/icict/33690/2/Epigenetic%20alterations%20are%20associated.pdf3a70c053abf28c73d1c3781061fcf350MD52TEXTEpigenetic alterations are associated.pdf.txtEpigenetic alterations are associated.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| title |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| spellingShingle |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection Espíndola, Milena Sobral HIV HIV |
| title_short |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| title_full |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| title_fullStr |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| title_full_unstemmed |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| title_sort |
Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection |
| author |
Espíndola, Milena Sobral |
| author_facet |
Espíndola, Milena Sobral Soares, Luana Silva Lima, Leonardo Judson Galvão de Zambuzi, Fabiana Albani Cacemiro, Maira da Costa Brauer, Verônica Soares Machado, Cleni Mara Marzocchi Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Martins Filho, Olindo Assis Bollela, Valdes Roberto Frantz, Fabiani Gai |
| author_role |
author |
| author2 |
Soares, Luana Silva Lima, Leonardo Judson Galvão de Zambuzi, Fabiana Albani Cacemiro, Maira da Costa Brauer, Verônica Soares Machado, Cleni Mara Marzocchi Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Martins Filho, Olindo Assis Bollela, Valdes Roberto Frantz, Fabiani Gai |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Espíndola, Milena Sobral Soares, Luana Silva Lima, Leonardo Judson Galvão de Zambuzi, Fabiana Albani Cacemiro, Maira da Costa Brauer, Verônica Soares Machado, Cleni Mara Marzocchi Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Martins Filho, Olindo Assis Bollela, Valdes Roberto Frantz, Fabiani Gai |
| dc.subject.other.pt_BR.fl_str_mv |
HIV |
| topic |
HIV HIV |
| dc.subject.en.pt_BR.fl_str_mv |
HIV |
| description |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. |
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2018 |
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2018 |
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2019-06-27T16:57:54Z |
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2019-06-27T16:57:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ESPÍNDOLA, Milena Sobral et al. Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection. Scientific Reports, v. 8, n. 1, 1-14, 2018. |
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https://www.arca.fiocruz.br/handle/icict/33690 |
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2045-2322 |
| dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-018-23841-1 |
| identifier_str_mv |
ESPÍNDOLA, Milena Sobral et al. Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection. Scientific Reports, v. 8, n. 1, 1-14, 2018. 2045-2322 10.1038/s41598-018-23841-1 |
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Nature Publishing Group |
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Nature Publishing Group |
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