Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.

Martins, Flaviano dos Santos; Vieira, Angélica Thomaz; Elian, Samir de Deus; Arantes, Rosa Maria Esteves; Tiago, Fabiana da Conceição Pereira; Sousa, Lirlândia Pires de; Araújo, Helena R.C.; Pimenta, Paulo Filemon Paolucci; Bonjardim, Cláudio Antonio; Nicoli, Jacques Robert; Teixeira, Mauro Martins

Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.

Detalhes bibliográficos
Autor(a) principal:	Martins, Flaviano dos Santos
Data de Publicação:	2013
Outros Autores:	Vieira, Angélica Thomaz, Elian, Samir de Deus, Arantes, Rosa Maria Esteves, Tiago, Fabiana da Conceição Pereira, Sousa, Lirlândia Pires de, Araújo, Helena R.C., Pimenta, Paulo Filemon Paolucci, Bonjardim, Cláudio Antonio, Nicoli, Jacques Robert, Teixeira, Mauro Martins
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/30739
Resumo:	Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil

Metadados do item

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spelling	Martins, Flaviano dos SantosVieira, Angélica ThomazElian, Samir de DeusArantes, Rosa Maria EstevesTiago, Fabiana da Conceição PereiraSousa, Lirlândia Pires deAraújo, Helena R.C.Pimenta, Paulo Filemon PaolucciBonjardim, Cláudio AntonioNicoli, Jacques RobertTeixeira, Mauro Martins2018-12-21T18:27:26Z2018-12-21T18:27:26Z2013MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 20131286-4579https://www.arca.fiocruz.br/handle/icict/3073910.1016/j.micinf.2012.12.007engElsevierSaccharomyces boulardiiSalmonella enterica serovar Typhimuriumtranslocação bacterianacitocinasSaccharomyces boulardiiSalmonella enterica serovar TyphimuriumBacterial translocationCytokinesMitogen-activated protein kinasesInhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFaculdade de Fármacia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilGrowing evidences suggest that Saccharomyces boulardii (SB) is efficacious against bacterial infections and inflammatory bowel diseases. This study investigated the effects of treatment with SB provided in a murine model of typhoid fever. Mice were divided into two groups: (1) control animals challenged with Salmonella Typhimurium (ST), and (2) animals receiving SB, and then challenged with ST. At days 0, 1, 5, 10 and 15 post-challenge, animals were euthanized and tissues collected to analyze bacterial translocation, cytokines, signaling pathways and histological analysis. Survival rate and animal weight were also evaluated. Treatment with SB increased survival rate and inhibited translocation of bacteria after ST challenge. Histological data showed that SB also protected mice against liver damage induced by ST. SB decreased levels of inflammatory cytokines and activation of mitogen-activated protein kinases (p38, JNK and ERK1/2), phospho-IκB, p65-RelA, phospho-jun and c-fos in the colon, signal pathways involved in the activation of inflammation induced by ST. Further experiments revealed that probiotic effects were due, at least in part, to the binding of ST to the yeast. Such binding diminishes ST translocation, resulting in decreased activation of signaling pathways which lead to intestinal inflammation in a murine model of typhoid fever.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30739/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALInhibition of tissue inflammation and bacterial translocation.pdfInhibition of tissue inflammation and bacterial translocation.pdfapplication/pdf5745525https://www.arca.fiocruz.br/bitstream/icict/30739/2/Inhibition%20of%20tissue%20inflammation%20and%20bacterial%20translocation.pdf20ce864a4910ae14276121be266f2f73MD52TEXTInhibition of tissue inflammation and bacterial translocation.pdf.txtInhibition of tissue inflammation and bacterial translocation.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
title	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
spellingShingle	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Martins, Flaviano dos Santos Saccharomyces boulardii Salmonella enterica serovar Typhimurium translocação bacteriana citocinas Saccharomyces boulardii Salmonella enterica serovar Typhimurium Bacterial translocation Cytokines Mitogen-activated protein kinases
title_short	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
title_full	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
title_fullStr	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
title_full_unstemmed	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
title_sort	Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
author	Martins, Flaviano dos Santos
author_facet	Martins, Flaviano dos Santos Vieira, Angélica Thomaz Elian, Samir de Deus Arantes, Rosa Maria Esteves Tiago, Fabiana da Conceição Pereira Sousa, Lirlândia Pires de Araújo, Helena R.C. Pimenta, Paulo Filemon Paolucci Bonjardim, Cláudio Antonio Nicoli, Jacques Robert Teixeira, Mauro Martins
author_role	author
author2	Vieira, Angélica Thomaz Elian, Samir de Deus Arantes, Rosa Maria Esteves Tiago, Fabiana da Conceição Pereira Sousa, Lirlândia Pires de Araújo, Helena R.C. Pimenta, Paulo Filemon Paolucci Bonjardim, Cláudio Antonio Nicoli, Jacques Robert Teixeira, Mauro Martins
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Martins, Flaviano dos Santos Vieira, Angélica Thomaz Elian, Samir de Deus Arantes, Rosa Maria Esteves Tiago, Fabiana da Conceição Pereira Sousa, Lirlândia Pires de Araújo, Helena R.C. Pimenta, Paulo Filemon Paolucci Bonjardim, Cláudio Antonio Nicoli, Jacques Robert Teixeira, Mauro Martins
dc.subject.other.pt_BR.fl_str_mv	Saccharomyces boulardii Salmonella enterica serovar Typhimurium translocação bacteriana citocinas
topic	Saccharomyces boulardii Salmonella enterica serovar Typhimurium translocação bacteriana citocinas Saccharomyces boulardii Salmonella enterica serovar Typhimurium Bacterial translocation Cytokines Mitogen-activated protein kinases
dc.subject.en.pt_BR.fl_str_mv	Saccharomyces boulardii Salmonella enterica serovar Typhimurium Bacterial translocation Cytokines Mitogen-activated protein kinases
description	Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil
publishDate	2013
dc.date.issued.fl_str_mv	2013
dc.date.accessioned.fl_str_mv	2018-12-21T18:27:26Z
dc.date.available.fl_str_mv	2018-12-21T18:27:26Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 2013
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/30739
dc.identifier.issn.pt_BR.fl_str_mv	1286-4579
dc.identifier.doi.none.fl_str_mv	10.1016/j.micinf.2012.12.007
identifier_str_mv	MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 2013 1286-4579 10.1016/j.micinf.2012.12.007
url	https://www.arca.fiocruz.br/handle/icict/30739
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/30739/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/30739/2/Inhibition%20of%20tissue%20inflammation%20and%20bacterial%20translocation.pdf https://www.arca.fiocruz.br/bitstream/icict/30739/3/Inhibition%20of%20tissue%20inflammation%20and%20bacterial%20translocation.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.

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