Immunopathology of cardiomyopathy in the experimental Chagas disease

Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.

Access type:openAccess
Publication Date:1999
Main Author: Soares, Milena Botelho Pereira
Other Authors: Santos, Ricardo Ribeiro dos
Document type: Article
Language:eng
Online Access:https://www.arca.fiocruz.br/handle/icict/5635
Citation:SOARES, Milena Botelho Pereira; SANTOS, Ricardo Ribeiro do. Immunopathology of cardiomyopathy in the experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl 1, p. 257-262, 1999.
English abstract:The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptured parasite nests release T. cruzi antigens that bind to the cell surface in the vicinity which become targets for the cellular and humoral immune response against T. cruzi. The various factors involved in the genesis of autoimmunity in chronic T. cruzi infection include molecular mimicry, presentation of self-antigens and imbalance of immune regulation.