Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28586 |
Resumo: | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil / Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil. |
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Naveca, Felipe GomesPontes, Gemilson SoaresChang, Aileen Yu-henSilva, George Allan Villarouco daNascimento, Valdinete Alves doMonteiro, Dana Cristina da SilvaSilva, Marineide Souza daAbdalla, Lígia FernandesSantos, João Hugo AbdallaAlmeida, Tatiana Amaral Pires deMejía, Matilde del Carmen ContrerasMesquita, Tirza Gabrielle Ramos deEncarnação, Helia Valeria de SouzaGomes, Matheus de SouzaAmaral, Laurence RodriguesAzevedo, Ana Carolina CampiReis, Jordana Grazziela Alves Coelho dosAntonelli, Lis Ribeiro do Vallede Carvalho, Andréa TeixeiraMartins Filho, Olindo AssisRamasawmy, Rajendranath2018-09-06T14:07:17Z2018-09-06T14:07:17Z2018NAVECA, Felipe Gomes et al. Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p. 1-13, 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2858610.1590/0074-02760170542engFundação Oswaldo CruzZika virusCXCL10BiomarcadoresQuimiocinasCitocinasZika virusCXCL10BiomarkersChemokinesCytokinesAnalysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damageinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil / Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Manaus, AM, Brasil.George Washington University. Washington DC, USA.Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil.Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil.Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil.Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil.Hospital Adventista de Manaus. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade Federal de Uberlândia. Patos de Minas, MG, Brasil.Universidade Federal de Uberlândia. Patos de Minas, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil/Universidade Nilton Lins. Manaus, AM, Brasil.BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS; We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. FINDINGS; ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distribution of the virus to organs and tissues. MAIN CONCLUSIONS: Biomarker network analysis demonstrated distinct dynamics in concurrence with the bimodal viremia profiles at different time points during ZIKV infection. Such a robust cytokine and chemokine response has been associated with blood-brain barrier permeability and neuroinvasiveness in other flaviviral infections. High-dimensional data analysis further identified CXCL10, a chemokine involved in foetal neuron apoptosis and Guillain-Barré syndrome, as the most promising biomarker of acute ZIKV infection for potential clinical application.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28586/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALAnalysis of the immunological biomarker profile during acute Zika.pdfAnalysis of the immunological biomarker profile during acute Zika.pdfapplication/pdf6295811https://www.arca.fiocruz.br/bitstream/icict/28586/2/Analysis%20of%20the%20immunological%20biomarker%20profile%20during%20acute%20Zika.pdf7eed4d772a1cb8ff7bc0171f9d4e649bMD52TEXTAnalysis of the immunological biomarker profile during acute Zika.pdf.txtAnalysis of the immunological biomarker profile during 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dc.title.pt_BR.fl_str_mv |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
title |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
spellingShingle |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage Naveca, Felipe Gomes Zika virus CXCL10 Biomarcadores Quimiocinas Citocinas Zika virus CXCL10 Biomarkers Chemokines Cytokines |
title_short |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
title_full |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
title_fullStr |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
title_full_unstemmed |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
title_sort |
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage |
author |
Naveca, Felipe Gomes |
author_facet |
Naveca, Felipe Gomes Pontes, Gemilson Soares Chang, Aileen Yu-hen Silva, George Allan Villarouco da Nascimento, Valdinete Alves do Monteiro, Dana Cristina da Silva Silva, Marineide Souza da Abdalla, Lígia Fernandes Santos, João Hugo Abdalla Almeida, Tatiana Amaral Pires de Mejía, Matilde del Carmen Contreras Mesquita, Tirza Gabrielle Ramos de Encarnação, Helia Valeria de Souza Gomes, Matheus de Souza Amaral, Laurence Rodrigues Azevedo, Ana Carolina Campi Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle de Carvalho, Andréa Teixeira Martins Filho, Olindo Assis Ramasawmy, Rajendranath |
author_role |
author |
author2 |
Pontes, Gemilson Soares Chang, Aileen Yu-hen Silva, George Allan Villarouco da Nascimento, Valdinete Alves do Monteiro, Dana Cristina da Silva Silva, Marineide Souza da Abdalla, Lígia Fernandes Santos, João Hugo Abdalla Almeida, Tatiana Amaral Pires de Mejía, Matilde del Carmen Contreras Mesquita, Tirza Gabrielle Ramos de Encarnação, Helia Valeria de Souza Gomes, Matheus de Souza Amaral, Laurence Rodrigues Azevedo, Ana Carolina Campi Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle de Carvalho, Andréa Teixeira Martins Filho, Olindo Assis Ramasawmy, Rajendranath |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Naveca, Felipe Gomes Pontes, Gemilson Soares Chang, Aileen Yu-hen Silva, George Allan Villarouco da Nascimento, Valdinete Alves do Monteiro, Dana Cristina da Silva Silva, Marineide Souza da Abdalla, Lígia Fernandes Santos, João Hugo Abdalla Almeida, Tatiana Amaral Pires de Mejía, Matilde del Carmen Contreras Mesquita, Tirza Gabrielle Ramos de Encarnação, Helia Valeria de Souza Gomes, Matheus de Souza Amaral, Laurence Rodrigues Azevedo, Ana Carolina Campi Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle de Carvalho, Andréa Teixeira Martins Filho, Olindo Assis Ramasawmy, Rajendranath |
dc.subject.other.pt_BR.fl_str_mv |
Zika virus CXCL10 Biomarcadores Quimiocinas Citocinas |
topic |
Zika virus CXCL10 Biomarcadores Quimiocinas Citocinas Zika virus CXCL10 Biomarkers Chemokines Cytokines |
dc.subject.en.pt_BR.fl_str_mv |
Zika virus CXCL10 Biomarkers Chemokines Cytokines |
description |
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil / Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-09-06T14:07:17Z |
dc.date.available.fl_str_mv |
2018-09-06T14:07:17Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NAVECA, Felipe Gomes et al. Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p. 1-13, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28586 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760170542 |
identifier_str_mv |
NAVECA, Felipe Gomes et al. Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p. 1-13, 2018. 0074-0276 10.1590/0074-02760170542 |
url |
https://www.arca.fiocruz.br/handle/icict/28586 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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