Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure
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| Data de Publicação: | 2013 |
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| Tipo de documento: | Artigo |
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Xavier-Elsas, Pedro PauloSilva, C. L. C. A.Pinto, L.Queto, T.Vieira, B. M.Aranha, M. G.De Luca, B.Masid de Brito, D.Luz, R. A.Lopes, R. S.Ferreira, R.Elsas, Maria Ignez Capella Gaspar2013-11-22T15:41:01Z2013-11-22T15:41:01Z2013XAVIER-ELSAS, P. et al. Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure. BioMed Research International, [S.l], v. 2013, p.1-11, 2013.https://www.arca.fiocruz.br/handle/icict/725210.1155/2013/474132CNPq, FAPERJ, PIBIC-FIOCRUZUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.Allergic airway inflammation is attenuated by oral tolerization (oral exposure to allergen, followed by conventional sensitization and challenge with homologous antigen), which decreases airway allergen challenge-induced eosinophilic infiltration of the lungs and bone marrow eosinophilia. We examined its effects on bone marrow eosinophil and neutrophil production. Mice of wild type (BP-2, BALB/c, and C57BL/6) and mutant strains (lacking iNOS or CD95L) were given ovalbumin (OVA) or water (vehicle) orally and subsequently sensitized and challenged with OVA (OVA/OVA/OVA and H2O/OVA/OVA groups, resp.). Anti-OVA IgG and IgE, bone marrow eosinophil and neutrophil numbers, and eosinophil and neutrophil production ex vivo were evaluated. T lymphocytes from OVA/OVA/OVA or control H2O/OVA/OVA donors were transferred into naïve syngeneic recipients, which were subsequently sensitized/challenged with OVA. Alternatively, T lymphocytes were cocultured with bone marrow eosinophil precursors from histocompatible sensitized/challenged mice. OVA/OVA/OVA mice of the BP-2 and BALB/c strains showed, relative to H2O/OVA/OVA controls, significantly decreased bone marrow eosinophil counts and ex vivo eosinopoiesis/neutropoiesis. Full effectiveness in vivo required sequential oral/subcutaneous/intranasal exposures to the same allergen. Transfer of splenic T lymphocytes from OVA/OVA/OVA donors to naive recipients prevented bone marrow eosinophilia and eosinopoiesis in response to recipient sensitization/challenge and supressed eosinopoiesis upon coculture with syngeneic bone marrow precursors from sensitized/challenged donors.porHindawi Publishing CorporationH. L. Weiner, A. P. da Cunha, F. Quintana, and H. Wu, “Oral tolerance,” Immunological Reviews, vol. 241, no. 1, pp. 241–259, 2011.A. M. C. Faria and H. L. Weiner, “Oral tolerance: therapeutic implications for autoimmune diseases,” Clinical and Developmental Immunology, vol. 13, no. 2–4, pp. 143–157, 2006.M. Russo, M. Nahori, J. Lefort et al., “Suppression of asthma-like responses in different mouse strains by oral tolerance,” American Journal of Respiratory Cell and Molecular Biology, vol. 24, no. 5, pp. 518–526, 2001.J. Shin, J. M. Kang, S. Won Kim, J. Cho, Y. J. Park, and S. W. Kim, “Effect of oral tolerance in a mouse model of allergic rhinitis,” Otolaryngology, vol. 142, no. 3, pp. 370–375, 2010.L. J. Vaickus, J. Bouchard, J. Kim, S. Natarajan, and D. G. Remick, “Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study,” Respiratory Research, vol. 11, article 160, 2010.C. M. Rodrigues, O. A. Martins-Filho, N. M. Vaz, and C. R. Carvalho, “Systemic effects of oral tolerance on inflammation: mobilization of lymphocytes and bone marrow eosinopoiesis,” Immunology, vol. 117, no. 4, pp. 517–525, 2006.B. C. A. M. van Esch, B. Schouten, S. de Kivit et al., “Oral tolerance induction by partially hydrolyzed whey protein in mice is associated with enhanced numbers of Foxp3+ regulatory T-cells in the mesenteric lymph nodes,” Pediatric Allergy and Immunology, vol. 22, no. 8, pp. 820–826, 2011.M. F. Du Pré, A. E. Kozijn, L. A. Van Berkel et al., “Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells,” Gastroenterology, vol. 141, pp. 610–620, 2011.M. E. Rothenberg and S. P. Hogan, “The eosinophil,” Annual Review of Immunology, vol. 24, pp. 147–174, 2006.J. J. Lee, D. Dimina, M. P. Macias et al., “Defining a link with asthma in mice congenitally deficient in eosinophils,” Science, vol. 305, no. 5691, pp. 1773–1776, 2004.A. A. Humbles, C. M. Lloyd, S. J. McMillan et al., “A critical role for eosinophils in allergic airways remodeling,” Science, vol. 305, no. 5691, pp. 1776–1779, 2004.M. M. Cyr and J. A. Denburg, “Systemic aspects of allergic disease: the role of the bone marrow,” Current Opinion in Immunology, vol. 13, no. 6, pp. 727–732, 2001.M. I. C. Gaspar Elsas, D. Joseph, P. X. Elsas, and B. B. Vargaftig, “Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge,” American Journal of Respiratory Cell and Molecular Biology, vol. 17, no. 4, pp. 404–413, 1997.M. I. C. Gaspar Elsas, E. S. Maximiano, D. Joseph, A. Bonomo, B. B. Vargaftig, and P. Xavier Elsas, “Isolation and characterization of hemopoietic cells from lungs of allergic mice,” Chest, vol. 123, no. 3, pp. 345S–348S, 2003.P. Xavier-Elsas, E. Santos-Maximiano, T. Queto et al., “Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients' lungs through an allergen- and interleukin-5-dependent mechanism,” Clinical and Experimental Allergy, vol. 37, no. 1, pp. 29–38, 2007.T. Queto, P. Xavier-Elsas, M. A. Gardel et al., “Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine,” American Journal of Respiratory and Critical Care Medicine, vol. 181, no. 5, pp. 429–437, 2010.T. Queto, Z. F. M. Vasconcelos, R. A. Luz et al., “G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production,” Life Sciences, vol. 88, no. 19-20, pp. 830–838, 2011.M. A. Horton, K. A. Larson, J. J. Lee, and N. A. Lee, “Cloning of the murine eosinophil peroxidase gene (mEPO): characterization of a conserved subgroup of mammalian hematopoietic peroxidases,” Journal of Leukocyte Biology, vol. 60, no. 2, pp. 285–294, 1996.P. Xavier Elsas, H. A. P. Neto, A. B. Cheraim et al., “Induction of bone-marrow eosinophilia in mice submitted to surgery is dependent on stress-induced secretion of glucocorticoids,” British Journal of Pharmacology, vol. 143, no. 5, pp. 541–548, 2004.E. S. Maximiano, P. X. Elsas, S. C. De Mendonça Sales et al., “Cells isolated from bone-marrow and lungs of allergic BALB/C mice and cultured in the presence of IL-5 are respectively resistant and susceptible to apoptosis induced by dexamethasone,” International Immunopharmacology, vol. 5, no. 5, pp. 857–870, 2005.H. Iwasaki, S. Mizuno, R. Mayfield et al., “Identification of eosinophil lineage-committed progenitors in the murine bone marrow,” Journal of Experimental Medicine, vol. 201, no. 12, pp. 1891–1897, 2005.R. Nishinakamura, A. Miyajima, P. J. Mee, V. L. J. Tybulewicz, and R. Murray, “Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions,” Blood, vol. 88, no. 7, pp. 2458–2464, 1996.D. Mucida, N. Kutchukhidze, A. Erazo, M. Russo, J. J. Lafaille, and M. A. Curotto De Lafaille, “Oral tolerance in the absence of naturally occurring Tregs,” Journal of Clinical Investigation, vol. 115, no. 7, pp. 1923–1933, 2005.K. Nagatani, M. Dohi, Y. To et al., “Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma,” Journal of Immunology, vol. 176, no. 3, pp. 1481–1489, 2006.H. van den Berg, M. Greuter, G. Kraal, and J. M. M. den Haan, “Different mechanisms regulate CD4+ T cell independent induction of oral and nasal tolerance of CD8+ T cells,” Immunobiology, vol. 215, no. 2, pp. 163–171, 2010.P. M. Arnaboldi, F. Roth-Walter, and L. 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| dc.title.pt_BR.fl_str_mv |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| title |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| spellingShingle |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure Xavier-Elsas, Pedro Paulo Medula Óssea Modulação Antigênica Imunidade nas Mucosas |
| title_short |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| title_full |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| title_fullStr |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| title_full_unstemmed |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| title_sort |
Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure |
| author |
Xavier-Elsas, Pedro Paulo |
| author_facet |
Xavier-Elsas, Pedro Paulo Silva, C. L. C. A. Pinto, L. Queto, T. Vieira, B. M. Aranha, M. G. De Luca, B. Masid de Brito, D. Luz, R. A. Lopes, R. S. Ferreira, R. Elsas, Maria Ignez Capella Gaspar |
| author_role |
author |
| author2 |
Silva, C. L. C. A. Pinto, L. Queto, T. Vieira, B. M. Aranha, M. G. De Luca, B. Masid de Brito, D. Luz, R. A. Lopes, R. S. Ferreira, R. Elsas, Maria Ignez Capella Gaspar |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Xavier-Elsas, Pedro Paulo Silva, C. L. C. A. Pinto, L. Queto, T. Vieira, B. M. Aranha, M. G. De Luca, B. Masid de Brito, D. Luz, R. A. Lopes, R. S. Ferreira, R. Elsas, Maria Ignez Capella Gaspar |
| dc.subject.decs.pt_BR.fl_str_mv |
Medula Óssea Modulação Antigênica Imunidade nas Mucosas |
| topic |
Medula Óssea Modulação Antigênica Imunidade nas Mucosas |
| description |
CNPq, FAPERJ, PIBIC-FIOCRUZ |
| publishDate |
2013 |
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2013-11-22T15:41:01Z |
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2013-11-22T15:41:01Z |
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2013 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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XAVIER-ELSAS, P. et al. Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure. BioMed Research International, [S.l], v. 2013, p.1-11, 2013. |
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https://www.arca.fiocruz.br/handle/icict/7252 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2013/474132 |
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XAVIER-ELSAS, P. et al. Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure. BioMed Research International, [S.l], v. 2013, p.1-11, 2013. 10.1155/2013/474132 |
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https://www.arca.fiocruz.br/handle/icict/7252 |
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por |
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por |
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H. L. Weiner, A. P. da Cunha, F. Quintana, and H. Wu, “Oral tolerance,” Immunological Reviews, vol. 241, no. 1, pp. 241–259, 2011. A. M. C. Faria and H. L. Weiner, “Oral tolerance: therapeutic implications for autoimmune diseases,” Clinical and Developmental Immunology, vol. 13, no. 2–4, pp. 143–157, 2006. M. Russo, M. Nahori, J. Lefort et al., “Suppression of asthma-like responses in different mouse strains by oral tolerance,” American Journal of Respiratory Cell and Molecular Biology, vol. 24, no. 5, pp. 518–526, 2001. J. Shin, J. M. Kang, S. Won Kim, J. Cho, Y. J. Park, and S. W. Kim, “Effect of oral tolerance in a mouse model of allergic rhinitis,” Otolaryngology, vol. 142, no. 3, pp. 370–375, 2010. L. J. Vaickus, J. Bouchard, J. Kim, S. Natarajan, and D. G. Remick, “Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study,” Respiratory Research, vol. 11, article 160, 2010. C. M. Rodrigues, O. A. Martins-Filho, N. M. Vaz, and C. R. Carvalho, “Systemic effects of oral tolerance on inflammation: mobilization of lymphocytes and bone marrow eosinopoiesis,” Immunology, vol. 117, no. 4, pp. 517–525, 2006. B. C. A. M. van Esch, B. Schouten, S. de Kivit et al., “Oral tolerance induction by partially hydrolyzed whey protein in mice is associated with enhanced numbers of Foxp3+ regulatory T-cells in the mesenteric lymph nodes,” Pediatric Allergy and Immunology, vol. 22, no. 8, pp. 820–826, 2011. M. F. Du Pré, A. E. Kozijn, L. A. Van Berkel et al., “Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells,” Gastroenterology, vol. 141, pp. 610–620, 2011. M. E. Rothenberg and S. P. Hogan, “The eosinophil,” Annual Review of Immunology, vol. 24, pp. 147–174, 2006. J. J. Lee, D. Dimina, M. P. Macias et al., “Defining a link with asthma in mice congenitally deficient in eosinophils,” Science, vol. 305, no. 5691, pp. 1773–1776, 2004. A. A. Humbles, C. M. Lloyd, S. J. McMillan et al., “A critical role for eosinophils in allergic airways remodeling,” Science, vol. 305, no. 5691, pp. 1776–1779, 2004. M. M. Cyr and J. A. Denburg, “Systemic aspects of allergic disease: the role of the bone marrow,” Current Opinion in Immunology, vol. 13, no. 6, pp. 727–732, 2001. M. I. C. Gaspar Elsas, D. Joseph, P. X. Elsas, and B. B. Vargaftig, “Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge,” American Journal of Respiratory Cell and Molecular Biology, vol. 17, no. 4, pp. 404–413, 1997. M. I. C. Gaspar Elsas, E. S. Maximiano, D. Joseph, A. Bonomo, B. B. Vargaftig, and P. Xavier Elsas, “Isolation and characterization of hemopoietic cells from lungs of allergic mice,” Chest, vol. 123, no. 3, pp. 345S–348S, 2003. P. Xavier-Elsas, E. Santos-Maximiano, T. Queto et al., “Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients' lungs through an allergen- and interleukin-5-dependent mechanism,” Clinical and Experimental Allergy, vol. 37, no. 1, pp. 29–38, 2007. T. Queto, P. Xavier-Elsas, M. A. Gardel et al., “Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine,” American Journal of Respiratory and Critical Care Medicine, vol. 181, no. 5, pp. 429–437, 2010. T. Queto, Z. F. M. Vasconcelos, R. A. Luz et al., “G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production,” Life Sciences, vol. 88, no. 19-20, pp. 830–838, 2011. M. A. Horton, K. A. Larson, J. J. Lee, and N. A. Lee, “Cloning of the murine eosinophil peroxidase gene (mEPO): characterization of a conserved subgroup of mammalian hematopoietic peroxidases,” Journal of Leukocyte Biology, vol. 60, no. 2, pp. 285–294, 1996. P. 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