Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Ana Carolina B. C
Data de Publicação: 2015
Outros Autores: Bomfim, Larissa Mendes, Neves, Sara P, Menezes, Leociley Rocha Alencar, Dias, Rosane Borges, Soares, Milena Botelho Pereira, Prata, Ana Paula N, Rocha, Clarissa Araújo Gurgel, Costa, Emmanoel Vilaça, Bezerra, Daniel Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11209
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Rodrigues, Ana Carolina B. CBomfim, Larissa MendesNeves, Sara PMenezes, Leociley Rocha AlencarDias, Rosane BorgesSoares, Milena Botelho PereiraPrata, Ana Paula NRocha, Clarissa Araújo GurgelCosta, Emmanoel VilaçaBezerra, Daniel Pereira2015-07-10T13:39:36Z2015-07-10T13:39:36Z2015RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 20150032-0943https://www.arca.fiocruz.br/handle/icict/1120910.1055/s-0035-1563130engGeorg Thieme VerlagAntitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Sergipe. Department of Chemistry. São Cristovão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFederal University of Sergipe. Department of Biology. São Cristovão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Propedêutica. Salvador, BA, BrasilFederal University of Amazonas. Department of Chemistry. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilDuguetia gardneriana, popularly known in the Brazilian northeast as “jaquinha”, is a species belonging to the family Annonaceae. The aim of this work was to assess the chemical composition and antitumor properties of the essential oil from the leaves of D. gardneriana in experimental models. The chemical composition of the essential oil was analyzed via gas chromatography-flame ionization detector and gas chromatography-mass spectrometry. In vitro cytotoxic activity was determined in cultured tumor cells, and in vivo antitumor activity was assessed in B16-F10-bearing mice. The identified compounds were β-bisabolene (80.99%), elemicin (8.04%), germacrene D (4.15%), and cyperene (2.82%). The essential oil exhibited a cytotoxic effect, with IC50 values of 16.89, 19.16, 13.08, and 19.33 μg/mL being obtained for B16-F10, HepG2, HL-60, and K562 cell lines, respectively. On the other hand, β-bisabolene was inactive in all of the tested tumor cell lines (showing IC50 values greater than 25 μg/ mL). The in vivo analysis revealed tumor growth inhibition rates of 5.37–37.52% at doses of 40 and 80mg/kg/day, respectively. Herein, the essential oil from the leaves of D. gardneriana presented β-bisabolene as the major constituent and showed cytotoxic and antitumor potential.Duguetia GardnerianaAnnonaceaeEssential oilCytotoxicAntitumorinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11209/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALRodrigues ACBC Antitumor....pdfRodrigues ACBC Antitumor....pdfapplication/pdf142853https://www.arca.fiocruz.br/bitstream/icict/11209/2/Rodrigues%20ACBC%20Antitumor....pdfdb7ecf9b40d453b0b76d913201aa845dMD52TEXTRodrigues ACBC Antitumor....pdf.txtRodrigues ACBC Antitumor....pdf.txtExtracted texttext/plain32744https://www.arca.fiocruz.br/bitstream/icict/11209/3/Rodrigues%20ACBC%20Antitumor....pdf.txta7ad84edf7080ebe5eedf1bdb6e3b185MD53icict/112092023-03-15 14:33:25.007oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
title Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
spellingShingle Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
Rodrigues, Ana Carolina B. C
Duguetia Gardneriana
Annonaceae
Essential oil
Cytotoxic
Antitumor
title_short Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
title_full Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
title_fullStr Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
title_full_unstemmed Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
title_sort Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
author Rodrigues, Ana Carolina B. C
author_facet Rodrigues, Ana Carolina B. C
Bomfim, Larissa Mendes
Neves, Sara P
Menezes, Leociley Rocha Alencar
Dias, Rosane Borges
Soares, Milena Botelho Pereira
Prata, Ana Paula N
Rocha, Clarissa Araújo Gurgel
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
author_role author
author2 Bomfim, Larissa Mendes
Neves, Sara P
Menezes, Leociley Rocha Alencar
Dias, Rosane Borges
Soares, Milena Botelho Pereira
Prata, Ana Paula N
Rocha, Clarissa Araújo Gurgel
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Ana Carolina B. C
Bomfim, Larissa Mendes
Neves, Sara P
Menezes, Leociley Rocha Alencar
Dias, Rosane Borges
Soares, Milena Botelho Pereira
Prata, Ana Paula N
Rocha, Clarissa Araújo Gurgel
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
dc.subject.en.pt_BR.fl_str_mv Duguetia Gardneriana
Annonaceae
Essential oil
Cytotoxic
Antitumor
topic Duguetia Gardneriana
Annonaceae
Essential oil
Cytotoxic
Antitumor
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-07-10T13:39:36Z
dc.date.available.fl_str_mv 2015-07-10T13:39:36Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 2015
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11209
dc.identifier.issn.none.fl_str_mv 0032-0943
dc.identifier.doi.none.fl_str_mv 10.1055/s-0035-1563130
identifier_str_mv RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 2015
0032-0943
10.1055/s-0035-1563130
url https://www.arca.fiocruz.br/handle/icict/11209
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Georg Thieme Verlag
publisher.none.fl_str_mv Georg Thieme Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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