Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit

Detalhes bibliográficos
Autor(a) principal: Oliveira, Mariana S. de
Data de Publicação: 2018
Outros Autores: Gontijo, Sávio M., Teixeira, Marina S., Teixeira, Karina I. Rosa, Takahashi, Jacqueline A., Millan, Rubén Dario Sinisterra, Segura, Maria Esperanza Cortés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27868
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.
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spelling Oliveira, Mariana S. deGontijo, Sávio M.Teixeira, Marina S.Teixeira, Karina I. RosaTakahashi, Jacqueline A.Millan, Rubén Dario SinisterraSegura, Maria Esperanza Cortés2018-08-06T12:54:48Z2018-08-06T12:54:48Z2018OLIVEIRA, Mariana S. de et al. Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit. Revista Fitos, Rio de Janeiro, v. 12, n. 2, p. 135-146, jul. 2018.https://www.arca.fiocruz.br/handle/icict/2786810.5935/2446-4775.201800132493-4775engFundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruitinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Odontologia. Departamento de Odontologia Restauradora. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Odontologia. Departamento de Odontologia Restauradora. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Odontologia. Departamento de Odontologia Restauradora. Belo Horizonte, MG, Brasil.In this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment.Schinus TerebinthifoliusAntifungalAntitumorCyclodextrinMalassezia Furfurinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/27868/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALmariana_de_oliveira_et_all.pdfapplication/pdf307300https://www.arca.fiocruz.br/bitstream/icict/27868/2/mariana_de_oliveira_et_all.pdf2fa843ec08410671b38a322869b31f42MD52TEXTmariana_de_oliveira_et_all.pdf.txtmariana_de_oliveira_et_all.pdf.txtExtracted texttext/plain33957https://www.arca.fiocruz.br/bitstream/icict/27868/3/mariana_de_oliveira_et_all.pdf.txt0b3fd4a2cd83e71ae87ca3b0d961ab94MD53icict/278682020-03-25 23:16:31.977oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-03-26T02:16:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
title Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
spellingShingle Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
Oliveira, Mariana S. de
Schinus Terebinthifolius
Antifungal
Antitumor
Cyclodextrin
Malassezia Furfur
title_short Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
title_full Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
title_fullStr Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
title_full_unstemmed Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
title_sort Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
author Oliveira, Mariana S. de
author_facet Oliveira, Mariana S. de
Gontijo, Sávio M.
Teixeira, Marina S.
Teixeira, Karina I. Rosa
Takahashi, Jacqueline A.
Millan, Rubén Dario Sinisterra
Segura, Maria Esperanza Cortés
author_role author
author2 Gontijo, Sávio M.
Teixeira, Marina S.
Teixeira, Karina I. Rosa
Takahashi, Jacqueline A.
Millan, Rubén Dario Sinisterra
Segura, Maria Esperanza Cortés
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Mariana S. de
Gontijo, Sávio M.
Teixeira, Marina S.
Teixeira, Karina I. Rosa
Takahashi, Jacqueline A.
Millan, Rubén Dario Sinisterra
Segura, Maria Esperanza Cortés
dc.subject.en.pt_BR.fl_str_mv Schinus Terebinthifolius
Antifungal
Antitumor
Cyclodextrin
Malassezia Furfur
topic Schinus Terebinthifolius
Antifungal
Antitumor
Cyclodextrin
Malassezia Furfur
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-06T12:54:48Z
dc.date.available.fl_str_mv 2018-08-06T12:54:48Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Mariana S. de et al. Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit. Revista Fitos, Rio de Janeiro, v. 12, n. 2, p. 135-146, jul. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27868
dc.identifier.doi.pt_BR.fl_str_mv 10.5935/2446-4775.20180013
dc.identifier.eissn.pt_BR.fl_str_mv 2493-4775
identifier_str_mv OLIVEIRA, Mariana S. de et al. Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit. Revista Fitos, Rio de Janeiro, v. 12, n. 2, p. 135-146, jul. 2018.
10.5935/2446-4775.20180013
2493-4775
url https://www.arca.fiocruz.br/handle/icict/27868
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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