Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Lemos, Denise da Silveira
Data de Publicação: 2010
Outros Autores: Carvalho, Andréa Teixeira, Martins Filho, Olindo Assis, Soares, Adriano Luiz Souza, Silva, Pollyanna Castro, Silva, Matheus Fernandes Costa, Guimarães, Pedro Henrique Gazzinelli, Ferraz, Helena Barbosa, Fraga, Lúcia Alves Oliveira, Teixeira, Mauro Martins, Oliveira, Rodrigo Corrêa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9384
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil /Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunoparasitologia. Ouro Preto, MG, Brasil
id CRUZ_4c6140fc7feb14357fcd4b1ce755b2fc
oai_identifier_str oai:www.arca.fiocruz.br:icict/9384
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Lemos, Denise da SilveiraCarvalho, Andréa TeixeiraMartins Filho, Olindo AssisSoares, Adriano Luiz SouzaSilva, Pollyanna CastroSilva, Matheus Fernandes CostaGuimarães, Pedro Henrique GazzinelliFerraz, Helena BarbosaFraga, Lúcia Alves OliveiraTeixeira, Mauro MartinsOliveira, Rodrigo Corrêa2015-01-14T15:05:57Z2015-01-14T15:05:57Z2010LEMOS, Denise Silveira et al. Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, vol. 105, n. 4, p. 380-386, 2010.0074-0276https://www.arca.fiocruz.br/handle/icict/938410.1590/S0074-02762010000400006engFundação Oswaldo CruzSeric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil /Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilThe recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.Chemokineseosinophilschemokine receptorsacute schistosomiasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9384/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALSeric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni.pdfSeric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni.pdfapplication/pdf496581https://www.arca.fiocruz.br/bitstream/icict/9384/2/Seric%20chemokines%20and%20chemokine%20receptors%20in%20eosinophils%20during%20acute%20human%20schistosomiasis%20mansoni.pdfd4d89dcfbae7448b93569b3a0e580164MD52TEXTSeric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni.pdf.txtSeric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni.pdf.txtExtracted texttext/plain39389https://www.arca.fiocruz.br/bitstream/icict/9384/3/Seric%20chemokines%20and%20chemokine%20receptors%20in%20eosinophils%20during%20acute%20human%20schistosomiasis%20mansoni.pdf.txtcfd3ed3e3623501a9f4a32b3469a2875MD53icict/93842019-06-19 10:07:42.169oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
spellingShingle Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
Lemos, Denise da Silveira
Chemokines
eosinophils
chemokine receptors
acute schistosomiasis
title_short Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_full Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_fullStr Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_full_unstemmed Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_sort Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
author Lemos, Denise da Silveira
author_facet Lemos, Denise da Silveira
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Soares, Adriano Luiz Souza
Silva, Pollyanna Castro
Silva, Matheus Fernandes Costa
Guimarães, Pedro Henrique Gazzinelli
Ferraz, Helena Barbosa
Fraga, Lúcia Alves Oliveira
Teixeira, Mauro Martins
Oliveira, Rodrigo Corrêa
author_role author
author2 Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Soares, Adriano Luiz Souza
Silva, Pollyanna Castro
Silva, Matheus Fernandes Costa
Guimarães, Pedro Henrique Gazzinelli
Ferraz, Helena Barbosa
Fraga, Lúcia Alves Oliveira
Teixeira, Mauro Martins
Oliveira, Rodrigo Corrêa
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lemos, Denise da Silveira
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Soares, Adriano Luiz Souza
Silva, Pollyanna Castro
Silva, Matheus Fernandes Costa
Guimarães, Pedro Henrique Gazzinelli
Ferraz, Helena Barbosa
Fraga, Lúcia Alves Oliveira
Teixeira, Mauro Martins
Oliveira, Rodrigo Corrêa
dc.subject.en.pt_BR.fl_str_mv Chemokines
eosinophils
chemokine receptors
acute schistosomiasis
topic Chemokines
eosinophils
chemokine receptors
acute schistosomiasis
description Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil /Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunoparasitologia. Ouro Preto, MG, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2015-01-14T15:05:57Z
dc.date.available.fl_str_mv 2015-01-14T15:05:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEMOS, Denise Silveira et al. Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, vol. 105, n. 4, p. 380-386, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9384
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762010000400006
identifier_str_mv LEMOS, Denise Silveira et al. Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, vol. 105, n. 4, p. 380-386, 2010.
0074-0276
10.1590/S0074-02762010000400006
url https://www.arca.fiocruz.br/handle/icict/9384
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/9384/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/9384/2/Seric%20chemokines%20and%20chemokine%20receptors%20in%20eosinophils%20during%20acute%20human%20schistosomiasis%20mansoni.pdf
https://www.arca.fiocruz.br/bitstream/icict/9384/3/Seric%20chemokines%20and%20chemokine%20receptors%20in%20eosinophils%20during%20acute%20human%20schistosomiasis%20mansoni.pdf.txt
bitstream.checksum.fl_str_mv 7d48279ffeed55da8dfe2f8e81f3b81f
d4d89dcfbae7448b93569b3a0e580164
cfd3ed3e3623501a9f4a32b3469a2875
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1794075571115786240