Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000100015 |
Resumo: | Different species of Panicum, including P. dichotomiflorum,have been reported as a cause of photosensitization in sheep, horses, cattle and goats. An outbreak of hepatogenous photosensitization occurred in 3 flocks of hair sheep in the Brazilian semiarid region. Eighty one out of 365 sheep were affected and 39 died. The main affected animals were nursing lambs and sheep younger than one year old. Donkeys, goats and cattle grazing in the same pasture were not affected. Clinical signs were edema of the head, followed by dermatitis, mainly in the face, ears, and croup, ocular discharge, corneal opacity with blindness, and redness of the coronary band and hoof. At necropsy of one affected lamb the liver was yellowish. Upon histologic examination scattered necrotic hepatocytes were observed in the liver and focal areas of necrosis of myocytes appeared in the heart. Samples of P. dicotomiflorum were analyzed by TLC and those containing saponins were isolated by HPLC using RP-C18 column and eluted with a mixture of MeOH and H2O. The isolated compounds were submitted to ¹H and 13C NMR spectroscopy. Reactions were positive to furostanol saponins with the same Rf of the standard protodioscin (0.21) and methylprotodioscin (0.32). The spectroscopic results indicated a mixture of (25R)- and (25S)-protodioscin isomers in a proportion of 3:1, and methylprotodioscin. |
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Sheep poisoning by Panicum dichotomiflorum in northeastern BrazilLithogenic steroidal saponinsPanicum dichotomiflorumphotosensitizationprotodioscinDifferent species of Panicum, including P. dichotomiflorum,have been reported as a cause of photosensitization in sheep, horses, cattle and goats. An outbreak of hepatogenous photosensitization occurred in 3 flocks of hair sheep in the Brazilian semiarid region. Eighty one out of 365 sheep were affected and 39 died. The main affected animals were nursing lambs and sheep younger than one year old. Donkeys, goats and cattle grazing in the same pasture were not affected. Clinical signs were edema of the head, followed by dermatitis, mainly in the face, ears, and croup, ocular discharge, corneal opacity with blindness, and redness of the coronary band and hoof. At necropsy of one affected lamb the liver was yellowish. Upon histologic examination scattered necrotic hepatocytes were observed in the liver and focal areas of necrosis of myocytes appeared in the heart. Samples of P. dicotomiflorum were analyzed by TLC and those containing saponins were isolated by HPLC using RP-C18 column and eluted with a mixture of MeOH and H2O. The isolated compounds were submitted to ¹H and 13C NMR spectroscopy. Reactions were positive to furostanol saponins with the same Rf of the standard protodioscin (0.21) and methylprotodioscin (0.32). The spectroscopic results indicated a mixture of (25R)- and (25S)-protodioscin isomers in a proportion of 3:1, and methylprotodioscin.Colégio Brasileiro de Patologia Animal - CBPA2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000100015Pesquisa Veterinária Brasileira v.29 n.1 2009reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2009000100015info:eu-repo/semantics/openAccessRiet-Correa,FranklinHaraguchi,MitsueDantas,Antônio F. M.Burakovas,Rodrigo G.Yokosuka,AkihitoMimaki,YoshihiroMedeiros,Rosane M.T.Matos,Polyanna F. deeng2009-03-12T00:00:00Zoai:scielo:S0100-736X2009000100015Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2009-03-12T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
title |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
spellingShingle |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil Riet-Correa,Franklin Lithogenic steroidal saponins Panicum dichotomiflorum photosensitization protodioscin |
title_short |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
title_full |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
title_fullStr |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
title_full_unstemmed |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
title_sort |
Sheep poisoning by Panicum dichotomiflorum in northeastern Brazil |
author |
Riet-Correa,Franklin |
author_facet |
Riet-Correa,Franklin Haraguchi,Mitsue Dantas,Antônio F. M. Burakovas,Rodrigo G. Yokosuka,Akihito Mimaki,Yoshihiro Medeiros,Rosane M.T. Matos,Polyanna F. de |
author_role |
author |
author2 |
Haraguchi,Mitsue Dantas,Antônio F. M. Burakovas,Rodrigo G. Yokosuka,Akihito Mimaki,Yoshihiro Medeiros,Rosane M.T. Matos,Polyanna F. de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Riet-Correa,Franklin Haraguchi,Mitsue Dantas,Antônio F. M. Burakovas,Rodrigo G. Yokosuka,Akihito Mimaki,Yoshihiro Medeiros,Rosane M.T. Matos,Polyanna F. de |
dc.subject.por.fl_str_mv |
Lithogenic steroidal saponins Panicum dichotomiflorum photosensitization protodioscin |
topic |
Lithogenic steroidal saponins Panicum dichotomiflorum photosensitization protodioscin |
description |
Different species of Panicum, including P. dichotomiflorum,have been reported as a cause of photosensitization in sheep, horses, cattle and goats. An outbreak of hepatogenous photosensitization occurred in 3 flocks of hair sheep in the Brazilian semiarid region. Eighty one out of 365 sheep were affected and 39 died. The main affected animals were nursing lambs and sheep younger than one year old. Donkeys, goats and cattle grazing in the same pasture were not affected. Clinical signs were edema of the head, followed by dermatitis, mainly in the face, ears, and croup, ocular discharge, corneal opacity with blindness, and redness of the coronary band and hoof. At necropsy of one affected lamb the liver was yellowish. Upon histologic examination scattered necrotic hepatocytes were observed in the liver and focal areas of necrosis of myocytes appeared in the heart. Samples of P. dicotomiflorum were analyzed by TLC and those containing saponins were isolated by HPLC using RP-C18 column and eluted with a mixture of MeOH and H2O. The isolated compounds were submitted to ¹H and 13C NMR spectroscopy. Reactions were positive to furostanol saponins with the same Rf of the standard protodioscin (0.21) and methylprotodioscin (0.32). The spectroscopic results indicated a mixture of (25R)- and (25S)-protodioscin isomers in a proportion of 3:1, and methylprotodioscin. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000100015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000100015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2009000100015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.29 n.1 2009 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122229194424320 |