Spontaneous and experimental poisoning by nitroxinil at 34% in goats
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Publication Date: | 2021 |
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Format: | Article |
Language: | eng |
Source: | Pesquisa Veterinária Brasileira (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100243 |
Summary: | ABSTRACT: This study describes the epidemiological, clinical, and pathological aspects of spontaneous and experimental poisoning by nitroxinil at 34% concentration in goats. The outbreak occurred on a farm in the municipality of Prata, Paraíba state. Nitroxinil was administered to a herd of 120 goats, of which 18 presented with anorexia, vocalization, abdominal distension, weakness, staggering, and falls. Necropsy of three goats revealed that the main lesion was acute liver injury. Histologically the liver showed centrilobular necrosis associated with hemorrhage and hepatocyte degeneration. In the kidneys, tubular nephrosis with granular cylinder formations was observed. The lungs showed multifocal to coalescent areas of moderate interalveolar edema and vascular congestion. Experimental poisoning was carried out in two goats, with the same medication and doses administered on the farm. The experimental goats showed clinical signs and macroscopic and histological changes similar to the spontaneously poisoned goats. The diagnosis of nitroxinil poisoning was made based on epidemiological, clinical, and pathological data, and confirmed by experimental poisoning. The administration of nitroxinil in high doses, associated with high ambient temperature and physical exercises, can cause poisoning with high lethality in goats. |
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Spontaneous and experimental poisoning by nitroxinil at 34% in goatsSpontaneous poisoningexperimental poisoningnitroxinilgoatsanthelminticoverdosecentrilobular hepatic necrosisnephrosisABSTRACT: This study describes the epidemiological, clinical, and pathological aspects of spontaneous and experimental poisoning by nitroxinil at 34% concentration in goats. The outbreak occurred on a farm in the municipality of Prata, Paraíba state. Nitroxinil was administered to a herd of 120 goats, of which 18 presented with anorexia, vocalization, abdominal distension, weakness, staggering, and falls. Necropsy of three goats revealed that the main lesion was acute liver injury. Histologically the liver showed centrilobular necrosis associated with hemorrhage and hepatocyte degeneration. In the kidneys, tubular nephrosis with granular cylinder formations was observed. The lungs showed multifocal to coalescent areas of moderate interalveolar edema and vascular congestion. Experimental poisoning was carried out in two goats, with the same medication and doses administered on the farm. The experimental goats showed clinical signs and macroscopic and histological changes similar to the spontaneously poisoned goats. The diagnosis of nitroxinil poisoning was made based on epidemiological, clinical, and pathological data, and confirmed by experimental poisoning. The administration of nitroxinil in high doses, associated with high ambient temperature and physical exercises, can cause poisoning with high lethality in goats.Colégio Brasileiro de Patologia Animal - CBPA2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100243Pesquisa Veterinária Brasileira v.41 2021reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/1678-5150-pvb-6935info:eu-repo/semantics/openAccessBrito Junior,João Ricardo C.Soares,Karoline L.Soares,Yanca G.S.Oliveira,Flaviane N.L.Alves,Renato V.Miranda Neto,Eldinê G.Dantas,Antônio Flávio M.Galiza,Glauco J.N.eng2021-10-28T00:00:00Zoai:scielo:S0100-736X2021000100243Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2021-10-28T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
title |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
spellingShingle |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats Brito Junior,João Ricardo C. Spontaneous poisoning experimental poisoning nitroxinil goats anthelmintic overdose centrilobular hepatic necrosis nephrosis |
title_short |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
title_full |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
title_fullStr |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
title_full_unstemmed |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
title_sort |
Spontaneous and experimental poisoning by nitroxinil at 34% in goats |
author |
Brito Junior,João Ricardo C. |
author_facet |
Brito Junior,João Ricardo C. Soares,Karoline L. Soares,Yanca G.S. Oliveira,Flaviane N.L. Alves,Renato V. Miranda Neto,Eldinê G. Dantas,Antônio Flávio M. Galiza,Glauco J.N. |
author_role |
author |
author2 |
Soares,Karoline L. Soares,Yanca G.S. Oliveira,Flaviane N.L. Alves,Renato V. Miranda Neto,Eldinê G. Dantas,Antônio Flávio M. Galiza,Glauco J.N. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Brito Junior,João Ricardo C. Soares,Karoline L. Soares,Yanca G.S. Oliveira,Flaviane N.L. Alves,Renato V. Miranda Neto,Eldinê G. Dantas,Antônio Flávio M. Galiza,Glauco J.N. |
dc.subject.por.fl_str_mv |
Spontaneous poisoning experimental poisoning nitroxinil goats anthelmintic overdose centrilobular hepatic necrosis nephrosis |
topic |
Spontaneous poisoning experimental poisoning nitroxinil goats anthelmintic overdose centrilobular hepatic necrosis nephrosis |
description |
ABSTRACT: This study describes the epidemiological, clinical, and pathological aspects of spontaneous and experimental poisoning by nitroxinil at 34% concentration in goats. The outbreak occurred on a farm in the municipality of Prata, Paraíba state. Nitroxinil was administered to a herd of 120 goats, of which 18 presented with anorexia, vocalization, abdominal distension, weakness, staggering, and falls. Necropsy of three goats revealed that the main lesion was acute liver injury. Histologically the liver showed centrilobular necrosis associated with hemorrhage and hepatocyte degeneration. In the kidneys, tubular nephrosis with granular cylinder formations was observed. The lungs showed multifocal to coalescent areas of moderate interalveolar edema and vascular congestion. Experimental poisoning was carried out in two goats, with the same medication and doses administered on the farm. The experimental goats showed clinical signs and macroscopic and histological changes similar to the spontaneously poisoned goats. The diagnosis of nitroxinil poisoning was made based on epidemiological, clinical, and pathological data, and confirmed by experimental poisoning. The administration of nitroxinil in high doses, associated with high ambient temperature and physical exercises, can cause poisoning with high lethality in goats. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100243 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2021000100243 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-5150-pvb-6935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.41 2021 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
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1754122240910163968 |