Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1069536 http://dx.doi.org/10.4238/gmr16019443 |
Resumo: | Abstract: Intense selection for production traits has improved the genetic gain of important economic traits. However, selection for performance and carcass traits has led to the onset of locomotors problems and decreasing bone strength in broilers. Thus, genes associated with bone integrity traits have become candidates for genetic studies in order to reduce the impact of bone disorders in broilers. This study investigated the association of the RUNX2 and TNFSF11 genes with 79 traits related to performance, carcass composition, organs, and bone integrity in a paternal broiler line. Analyses of genetic association between single-nucleotide polymorphisms (SNPs) and traits were carried out using the maximum likelihood procedures for mixed models. Genetic associations (P < 0.05) were found between SNP g.124,883A>G in the RUNX2 gene and chilled femur weight (additive plus dominance deviation effects within sex) and with performance traits (additive within sex and additive effects). The SNP g.14,862T>C in the TNFSF11 gene presented genetic associations (P < 0.05) with additive plus dominance deviation effects within sex for performance traits. Suggestive genetic associations (P < 0.10) were found with abdominal fat and its yield. Selection based on SNPs g.14,862T>C in TNFSF11 and g.124,883A>G in RUNX2 could be used to improve performance and carcass quality traits in the population studied, although SNP g.14,862T>C was not in Hardy-Weinberg equilibrium because it was not undergoing a selection process. Furthermore, it is important to validate these markers in an unrelated population for use in the selection process. |
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Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line.Melhoramento genético animalFrango de corteAnimal breedingBroiler chickensAbstract: Intense selection for production traits has improved the genetic gain of important economic traits. However, selection for performance and carcass traits has led to the onset of locomotors problems and decreasing bone strength in broilers. Thus, genes associated with bone integrity traits have become candidates for genetic studies in order to reduce the impact of bone disorders in broilers. This study investigated the association of the RUNX2 and TNFSF11 genes with 79 traits related to performance, carcass composition, organs, and bone integrity in a paternal broiler line. Analyses of genetic association between single-nucleotide polymorphisms (SNPs) and traits were carried out using the maximum likelihood procedures for mixed models. Genetic associations (P < 0.05) were found between SNP g.124,883A>G in the RUNX2 gene and chilled femur weight (additive plus dominance deviation effects within sex) and with performance traits (additive within sex and additive effects). The SNP g.14,862T>C in the TNFSF11 gene presented genetic associations (P < 0.05) with additive plus dominance deviation effects within sex for performance traits. Suggestive genetic associations (P < 0.10) were found with abdominal fat and its yield. Selection based on SNPs g.14,862T>C in TNFSF11 and g.124,883A>G in RUNX2 could be used to improve performance and carcass quality traits in the population studied, although SNP g.14,862T>C was not in Hardy-Weinberg equilibrium because it was not undergoing a selection process. Furthermore, it is important to validate these markers in an unrelated population for use in the selection process.NATALIA VINHAL GRUPIONI, UNESP/Jaboticabal; NEDENIA BONVINO STAFUZZA, UNESP/Jaboticabal; ALEJANDRO BARRERA, UNESP/Jaboticabal; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MONICA CORREA LEDUR, CNPSA; DANÍSIO PRADO MUNARI, UNESP/Jaboticabal.GRUPIONI, N. V.STAFUZZA, N. B.CARVAJAL, A. B.IBELLI, A. M. G.PEIXOTO, J. de O.LEDUR, M. C.MUNARI, D. P.2018-01-26T23:44:02Z2018-01-26T23:44:02Z2017-05-1120172018-01-26T23:44:02Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGenetics and Molecular Research, v. 16, n.1, 2017.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1069536http://dx.doi.org/10.4238/gmr16019443enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2018-01-26T23:44:09Zoai:www.alice.cnptia.embrapa.br:doc/1069536Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542018-01-26T23:44:09falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542018-01-26T23:44:09Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
title |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
spellingShingle |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. GRUPIONI, N. V. Melhoramento genético animal Frango de corte Animal breeding Broiler chickens |
title_short |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
title_full |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
title_fullStr |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
title_full_unstemmed |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
title_sort |
Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. |
author |
GRUPIONI, N. V. |
author_facet |
GRUPIONI, N. V. STAFUZZA, N. B. CARVAJAL, A. B. IBELLI, A. M. G. PEIXOTO, J. de O. LEDUR, M. C. MUNARI, D. P. |
author_role |
author |
author2 |
STAFUZZA, N. B. CARVAJAL, A. B. IBELLI, A. M. G. PEIXOTO, J. de O. LEDUR, M. C. MUNARI, D. P. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
NATALIA VINHAL GRUPIONI, UNESP/Jaboticabal; NEDENIA BONVINO STAFUZZA, UNESP/Jaboticabal; ALEJANDRO BARRERA, UNESP/Jaboticabal; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MONICA CORREA LEDUR, CNPSA; DANÍSIO PRADO MUNARI, UNESP/Jaboticabal. |
dc.contributor.author.fl_str_mv |
GRUPIONI, N. V. STAFUZZA, N. B. CARVAJAL, A. B. IBELLI, A. M. G. PEIXOTO, J. de O. LEDUR, M. C. MUNARI, D. P. |
dc.subject.por.fl_str_mv |
Melhoramento genético animal Frango de corte Animal breeding Broiler chickens |
topic |
Melhoramento genético animal Frango de corte Animal breeding Broiler chickens |
description |
Abstract: Intense selection for production traits has improved the genetic gain of important economic traits. However, selection for performance and carcass traits has led to the onset of locomotors problems and decreasing bone strength in broilers. Thus, genes associated with bone integrity traits have become candidates for genetic studies in order to reduce the impact of bone disorders in broilers. This study investigated the association of the RUNX2 and TNFSF11 genes with 79 traits related to performance, carcass composition, organs, and bone integrity in a paternal broiler line. Analyses of genetic association between single-nucleotide polymorphisms (SNPs) and traits were carried out using the maximum likelihood procedures for mixed models. Genetic associations (P < 0.05) were found between SNP g.124,883A>G in the RUNX2 gene and chilled femur weight (additive plus dominance deviation effects within sex) and with performance traits (additive within sex and additive effects). The SNP g.14,862T>C in the TNFSF11 gene presented genetic associations (P < 0.05) with additive plus dominance deviation effects within sex for performance traits. Suggestive genetic associations (P < 0.10) were found with abdominal fat and its yield. Selection based on SNPs g.14,862T>C in TNFSF11 and g.124,883A>G in RUNX2 could be used to improve performance and carcass quality traits in the population studied, although SNP g.14,862T>C was not in Hardy-Weinberg equilibrium because it was not undergoing a selection process. Furthermore, it is important to validate these markers in an unrelated population for use in the selection process. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-11 2017 2018-01-26T23:44:02Z 2018-01-26T23:44:02Z 2018-01-26T23:44:02Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Genetics and Molecular Research, v. 16, n.1, 2017. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1069536 http://dx.doi.org/10.4238/gmr16019443 |
identifier_str_mv |
Genetics and Molecular Research, v. 16, n.1, 2017. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1069536 http://dx.doi.org/10.4238/gmr16019443 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503448782176256 |