Cytokine profile associated with human chronic schistosomiasis mansoni
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004 |
Resumo: | This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni. |
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Memórias do Instituto Oswaldo Cruz |
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Cytokine profile associated with human chronic schistosomiasis mansonischistosomiasishepatic fibrosisinterleukin-5interleukin-13This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.Instituto Oswaldo Cruz, Ministério da Saúde2004-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004Memórias do Instituto Oswaldo Cruz v.99 suppl.1 2004reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762004000900004info:eu-repo/semantics/openAccessMagalhães,AndréaMiranda,Delfin GonzalezMiranda,Roberval GonzalezAraújo,Maria IlmaJesus,Adriana Almeida deSilva,AngelaSantana,Luciana BPearce,EdwardCarvalho,Edgar MJesus,Amélia Ribeiro deeng2020-04-25T17:49:21Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:12:55.589Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Cytokine profile associated with human chronic schistosomiasis mansoni |
title |
Cytokine profile associated with human chronic schistosomiasis mansoni |
spellingShingle |
Cytokine profile associated with human chronic schistosomiasis mansoni Magalhães,Andréa schistosomiasis hepatic fibrosis interleukin-5 interleukin-13 |
title_short |
Cytokine profile associated with human chronic schistosomiasis mansoni |
title_full |
Cytokine profile associated with human chronic schistosomiasis mansoni |
title_fullStr |
Cytokine profile associated with human chronic schistosomiasis mansoni |
title_full_unstemmed |
Cytokine profile associated with human chronic schistosomiasis mansoni |
title_sort |
Cytokine profile associated with human chronic schistosomiasis mansoni |
author |
Magalhães,Andréa |
author_facet |
Magalhães,Andréa Miranda,Delfin Gonzalez Miranda,Roberval Gonzalez Araújo,Maria Ilma Jesus,Adriana Almeida de Silva,Angela Santana,Luciana B Pearce,Edward Carvalho,Edgar M Jesus,Amélia Ribeiro de |
author_role |
author |
author2 |
Miranda,Delfin Gonzalez Miranda,Roberval Gonzalez Araújo,Maria Ilma Jesus,Adriana Almeida de Silva,Angela Santana,Luciana B Pearce,Edward Carvalho,Edgar M Jesus,Amélia Ribeiro de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Magalhães,Andréa Miranda,Delfin Gonzalez Miranda,Roberval Gonzalez Araújo,Maria Ilma Jesus,Adriana Almeida de Silva,Angela Santana,Luciana B Pearce,Edward Carvalho,Edgar M Jesus,Amélia Ribeiro de |
dc.subject.por.fl_str_mv |
schistosomiasis hepatic fibrosis interleukin-5 interleukin-13 |
topic |
schistosomiasis hepatic fibrosis interleukin-5 interleukin-13 |
dc.description.none.fl_txt_mv |
This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni. |
description |
This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762004000900004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.99 suppl.1 2004 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937693099819008 |