Preparation and antitubercular activity of lipophilic diamines and amino alcohols

Detalhes bibliográficos
Autor(a) principal: OR Júnior,Celso
Data de Publicação: 2009
Outros Autores: Le Hyaric,Mireille, Costa,Cristiane F da, Corrêa,Taís A, Taveira,Aline F, Araújo,Débora P, Reis,Elaine FC, Lourenço,Maria Cristina S, Vicente,Felipe RC, Almeida,Mauro V de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500006
Resumo: A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.
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spelling Preparation and antitubercular activity of lipophilic diamines and amino alcoholstuberculosisamino alcoholsdiamineslipophilicityA series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.Instituto Oswaldo Cruz, Ministério da Saúde2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500006Memórias do Instituto Oswaldo Cruz v.104 n.5 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000500006info:eu-repo/semantics/openAccessOR Júnior,CelsoLe Hyaric,MireilleCosta,Cristiane F daCorrêa,Taís ATaveira,Aline FAraújo,Débora PReis,Elaine FCLourenço,Maria Cristina SVicente,Felipe RCAlmeida,Mauro V deeng2020-04-25T17:50:31Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:19.322Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title Preparation and antitubercular activity of lipophilic diamines and amino alcohols
spellingShingle Preparation and antitubercular activity of lipophilic diamines and amino alcohols
OR Júnior,Celso
tuberculosis
amino alcohols
diamines
lipophilicity
title_short Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_full Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_fullStr Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_full_unstemmed Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_sort Preparation and antitubercular activity of lipophilic diamines and amino alcohols
author OR Júnior,Celso
author_facet OR Júnior,Celso
Le Hyaric,Mireille
Costa,Cristiane F da
Corrêa,Taís A
Taveira,Aline F
Araújo,Débora P
Reis,Elaine FC
Lourenço,Maria Cristina S
Vicente,Felipe RC
Almeida,Mauro V de
author_role author
author2 Le Hyaric,Mireille
Costa,Cristiane F da
Corrêa,Taís A
Taveira,Aline F
Araújo,Débora P
Reis,Elaine FC
Lourenço,Maria Cristina S
Vicente,Felipe RC
Almeida,Mauro V de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv OR Júnior,Celso
Le Hyaric,Mireille
Costa,Cristiane F da
Corrêa,Taís A
Taveira,Aline F
Araújo,Débora P
Reis,Elaine FC
Lourenço,Maria Cristina S
Vicente,Felipe RC
Almeida,Mauro V de
dc.subject.por.fl_str_mv tuberculosis
amino alcohols
diamines
lipophilicity
topic tuberculosis
amino alcohols
diamines
lipophilicity
dc.description.none.fl_txt_mv A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.
description A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500006
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762009000500006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.104 n.5 2009
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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