Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats

Detalhes bibliográficos
Autor(a) principal: Freitas,Deborah Queiroz de
Data de Publicação: 2012
Outros Autores: Ramos-Perez,Flávia Maria de Moraes, Neves,Ellen Gaby, Marques,Marcelo Rocha, Bóscolo,Frab Norberto, Almeida,Solange Maria de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017
Resumo: This studyevaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity.
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spelling Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized ratsradiotherapyosteoporosisseleniumovariectomyThis studyevaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity.Fundação Odontológica de Ribeirão Preto2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017Brazilian Dental Journal v.23 n.6 2012reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402012000600017info:eu-repo/semantics/openAccessFreitas,Deborah Queiroz deRamos-Perez,Flávia Maria de MoraesNeves,Ellen GabyMarques,Marcelo RochaBóscolo,Frab NorbertoAlmeida,Solange Maria deeng2013-01-18T00:00:00Zoai:scielo:S0103-64402012000600017Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2013-01-18T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
title Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
spellingShingle Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
Freitas,Deborah Queiroz de
radiotherapy
osteoporosis
selenium
ovariectomy
title_short Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
title_full Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
title_fullStr Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
title_full_unstemmed Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
title_sort Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
author Freitas,Deborah Queiroz de
author_facet Freitas,Deborah Queiroz de
Ramos-Perez,Flávia Maria de Moraes
Neves,Ellen Gaby
Marques,Marcelo Rocha
Bóscolo,Frab Norberto
Almeida,Solange Maria de
author_role author
author2 Ramos-Perez,Flávia Maria de Moraes
Neves,Ellen Gaby
Marques,Marcelo Rocha
Bóscolo,Frab Norberto
Almeida,Solange Maria de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas,Deborah Queiroz de
Ramos-Perez,Flávia Maria de Moraes
Neves,Ellen Gaby
Marques,Marcelo Rocha
Bóscolo,Frab Norberto
Almeida,Solange Maria de
dc.subject.por.fl_str_mv radiotherapy
osteoporosis
selenium
ovariectomy
topic radiotherapy
osteoporosis
selenium
ovariectomy
description This studyevaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402012000600017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.23 n.6 2012
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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