DC-STAMP and TACE Levels are Higher in Patients with Periodontitis
Main Author: | |
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Publication Date: | 2020 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Brazilian Dental Journal |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402020000200122 |
Summary: | Abstract Although periodontitis is one of the commonest infectious inflammatory diseases in humans, the mechanisms involved with its immunopathology remain ill understood. Numerous molecules may induce inflammation and lead to bone resorption, secondary to activation of monocytes into osteoclasts. TACE (TNF-α converting enzyme) and DC-STAMP (dendritic cell-specific transmembrane protein) appear to play a role on bone resorption since TACE induces the release of sRANKL (soluble receptor activator of nuclear factor kappa-β ligand) whereas DC-STAMP is a key factor in osteoclast induction. The present study evaluated the levels of TACE and DC-STAMP in patients with and without periodontitis. Twenty individuals were selected: 10 periodontally healthy participants undergoing gingivectomy for esthetic reasons and 10 diagnosed with periodontitis. Protein levels of such molecules in gingival tissue were established using Western blotting. Protein levels of both TACE and DC-STAMP were higher in the periodontitis group than in the control group (p<0.05; Student t-test). In conclusion, TACE and DC-STAMP protein levels are elevated in patients with periodontitis, favoring progression of bone resorption. |
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DC-STAMP and TACE Levels are Higher in Patients with PeriodontitisperiodontitisinflammationTACEDC-STAMPbone resorptionAbstract Although periodontitis is one of the commonest infectious inflammatory diseases in humans, the mechanisms involved with its immunopathology remain ill understood. Numerous molecules may induce inflammation and lead to bone resorption, secondary to activation of monocytes into osteoclasts. TACE (TNF-α converting enzyme) and DC-STAMP (dendritic cell-specific transmembrane protein) appear to play a role on bone resorption since TACE induces the release of sRANKL (soluble receptor activator of nuclear factor kappa-β ligand) whereas DC-STAMP is a key factor in osteoclast induction. The present study evaluated the levels of TACE and DC-STAMP in patients with and without periodontitis. Twenty individuals were selected: 10 periodontally healthy participants undergoing gingivectomy for esthetic reasons and 10 diagnosed with periodontitis. Protein levels of such molecules in gingival tissue were established using Western blotting. Protein levels of both TACE and DC-STAMP were higher in the periodontitis group than in the control group (p<0.05; Student t-test). In conclusion, TACE and DC-STAMP protein levels are elevated in patients with periodontitis, favoring progression of bone resorption.Fundação Odontológica de Ribeirão Preto2020-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402020000200122Brazilian Dental Journal v.31 n.2 2020reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440202002939info:eu-repo/semantics/openAccessGuardiola,Cyro José de AlmeidaClemente-Napimoga,Juliana TrindadeMartinez,Elizabeth FerreiraAbdalla,Henrique BalassiniPeruzzo,Daiane CristinaJoly,Júlio CésarNapimoga,Marcelo Henriqueeng2020-06-10T00:00:00Zoai:scielo:S0103-64402020000200122Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2020-06-10T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
title |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
spellingShingle |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis Guardiola,Cyro José de Almeida periodontitis inflammation TACE DC-STAMP bone resorption |
title_short |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
title_full |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
title_fullStr |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
title_full_unstemmed |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
title_sort |
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis |
author |
Guardiola,Cyro José de Almeida |
author_facet |
Guardiola,Cyro José de Almeida Clemente-Napimoga,Juliana Trindade Martinez,Elizabeth Ferreira Abdalla,Henrique Balassini Peruzzo,Daiane Cristina Joly,Júlio César Napimoga,Marcelo Henrique |
author_role |
author |
author2 |
Clemente-Napimoga,Juliana Trindade Martinez,Elizabeth Ferreira Abdalla,Henrique Balassini Peruzzo,Daiane Cristina Joly,Júlio César Napimoga,Marcelo Henrique |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Guardiola,Cyro José de Almeida Clemente-Napimoga,Juliana Trindade Martinez,Elizabeth Ferreira Abdalla,Henrique Balassini Peruzzo,Daiane Cristina Joly,Júlio César Napimoga,Marcelo Henrique |
dc.subject.por.fl_str_mv |
periodontitis inflammation TACE DC-STAMP bone resorption |
topic |
periodontitis inflammation TACE DC-STAMP bone resorption |
description |
Abstract Although periodontitis is one of the commonest infectious inflammatory diseases in humans, the mechanisms involved with its immunopathology remain ill understood. Numerous molecules may induce inflammation and lead to bone resorption, secondary to activation of monocytes into osteoclasts. TACE (TNF-α converting enzyme) and DC-STAMP (dendritic cell-specific transmembrane protein) appear to play a role on bone resorption since TACE induces the release of sRANKL (soluble receptor activator of nuclear factor kappa-β ligand) whereas DC-STAMP is a key factor in osteoclast induction. The present study evaluated the levels of TACE and DC-STAMP in patients with and without periodontitis. Twenty individuals were selected: 10 periodontally healthy participants undergoing gingivectomy for esthetic reasons and 10 diagnosed with periodontitis. Protein levels of such molecules in gingival tissue were established using Western blotting. Protein levels of both TACE and DC-STAMP were higher in the periodontitis group than in the control group (p<0.05; Student t-test). In conclusion, TACE and DC-STAMP protein levels are elevated in patients with periodontitis, favoring progression of bone resorption. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402020000200122 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402020000200122 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-6440202002939 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.31 n.2 2020 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204095795691520 |