HIV-1 subtype C dissemination in southern Brazil

Detalhes bibliográficos
Autor(a) principal: Soares, Esmeralda Augusta Jardim Machado
Data de Publicação: 2005
Outros Autores: Martinez, Ana Maria Barral de, Souza, Thatiana, Santos, André Felipe Andrade dos, Hora, Vanusa Pousada da, Silveira, Jussara Maria, Bastos, Francisco, Tanuri, Amilcar, Soares, Marcelo Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/3534
Resumo: Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross-sectional study was conducted from September to December 2002. Plasma viral RNA of 85 patients was extracted and protease and reverse transcriptase genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined to antiretroviral resistance mutations. Laboratory data and past history of antiretroviral treatment were also collected. Results: Most viruses were either subtype B (42%) or subtype C (45%). No risk behaviour, sexual orientation or laboratory parameter was associated with any specific subtype, but subtype C tended to be more frequently found in women (P ¼ 0.06). The prevalence of subtype C has increased over the HIV/AIDS epidemic, accounting for almost 60% of cases diagnosed in 2002. Intra-subtype genetic distances were smaller in subtype C than in subtype B, suggesting a more recent introduction of the former in the epidemic. Of patients under treatment, 60% had at least one antiretroviral drug resistance mutation, but no mutation was specifically associated with any HIV-1 subtype. Only one resistance mutation each was found in drug-naive patients with subtypes B and C. Conclusion: Despite the fact that subtype C appeared in southern Brazil more recently than subtype B, it is now the predominant strain in Rio Grande. The epidemic spread of subtype C could be taking place in Brazil, and possibly in south America, a phenomenon similar to that seen in other countries where this subtype is now totally dominant.
id FURG_3dc8353fcec246b029744162be32d1e3
oai_identifier_str oai:repositorio.furg.br:1/3534
network_acronym_str FURG
network_name_str Repositório Institucional da FURG (RI FURG)
repository_id_str
spelling Soares, Esmeralda Augusta Jardim MachadoMartinez, Ana Maria Barral deSouza, ThatianaSantos, André Felipe Andrade dosHora, Vanusa Pousada daSilveira, Jussara MariaBastos, FranciscoTanuri, AmilcarSoares, Marcelo Alves2013-06-17T18:10:29Z2013-06-17T18:10:29Z2005SOARES, Esmeralda Augusta Jardim Machado et al. HIV1 subtype C dissemination in the southern Brazil. AIDS, London, v. 19, p. S81-S86, 2005. Disponível em: <http://journals.lww.com/aidsonline/Fulltext/2005/10004/HIV_1_subtype_C_dissemination_in_southern_Brazil.14.aspx>. Acesso em: 10 set. 2012.0269-9370http://repositorio.furg.br/handle/1/3534Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross-sectional study was conducted from September to December 2002. Plasma viral RNA of 85 patients was extracted and protease and reverse transcriptase genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined to antiretroviral resistance mutations. Laboratory data and past history of antiretroviral treatment were also collected. Results: Most viruses were either subtype B (42%) or subtype C (45%). No risk behaviour, sexual orientation or laboratory parameter was associated with any specific subtype, but subtype C tended to be more frequently found in women (P ¼ 0.06). The prevalence of subtype C has increased over the HIV/AIDS epidemic, accounting for almost 60% of cases diagnosed in 2002. Intra-subtype genetic distances were smaller in subtype C than in subtype B, suggesting a more recent introduction of the former in the epidemic. Of patients under treatment, 60% had at least one antiretroviral drug resistance mutation, but no mutation was specifically associated with any HIV-1 subtype. Only one resistance mutation each was found in drug-naive patients with subtypes B and C. Conclusion: Despite the fact that subtype C appeared in southern Brazil more recently than subtype B, it is now the predominant strain in Rio Grande. The epidemic spread of subtype C could be taking place in Brazil, and possibly in south America, a phenomenon similar to that seen in other countries where this subtype is now totally dominant.engHIV-1Molecular epidemiologySouthern BrazilSubtype CHIV-1 subtype C dissemination in southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALHIV-1 subtype C dissemination in southern Brazil.pdfHIV-1 subtype C dissemination in southern Brazil.pdfapplication/pdf141013https://repositorio.furg.br/bitstream/1/3534/1/HIV-1%20subtype%20C%20dissemination%20in%20southern%20Brazil.pdfa01d4d08928639b3401ccf8579fd6462MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81678https://repositorio.furg.br/bitstream/1/3534/2/license.txtd3be63d3b3eee02729709361dac69efeMD52open access1/35342019-11-22 10:09:54.868open accessoai:repositorio.furg.br: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ório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-22T13:09:54Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv HIV-1 subtype C dissemination in southern Brazil
title HIV-1 subtype C dissemination in southern Brazil
spellingShingle HIV-1 subtype C dissemination in southern Brazil
Soares, Esmeralda Augusta Jardim Machado
HIV-1
Molecular epidemiology
Southern Brazil
Subtype C
title_short HIV-1 subtype C dissemination in southern Brazil
title_full HIV-1 subtype C dissemination in southern Brazil
title_fullStr HIV-1 subtype C dissemination in southern Brazil
title_full_unstemmed HIV-1 subtype C dissemination in southern Brazil
title_sort HIV-1 subtype C dissemination in southern Brazil
author Soares, Esmeralda Augusta Jardim Machado
author_facet Soares, Esmeralda Augusta Jardim Machado
Martinez, Ana Maria Barral de
Souza, Thatiana
Santos, André Felipe Andrade dos
Hora, Vanusa Pousada da
Silveira, Jussara Maria
Bastos, Francisco
Tanuri, Amilcar
Soares, Marcelo Alves
author_role author
author2 Martinez, Ana Maria Barral de
Souza, Thatiana
Santos, André Felipe Andrade dos
Hora, Vanusa Pousada da
Silveira, Jussara Maria
Bastos, Francisco
Tanuri, Amilcar
Soares, Marcelo Alves
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Esmeralda Augusta Jardim Machado
Martinez, Ana Maria Barral de
Souza, Thatiana
Santos, André Felipe Andrade dos
Hora, Vanusa Pousada da
Silveira, Jussara Maria
Bastos, Francisco
Tanuri, Amilcar
Soares, Marcelo Alves
dc.subject.por.fl_str_mv HIV-1
Molecular epidemiology
Southern Brazil
Subtype C
topic HIV-1
Molecular epidemiology
Southern Brazil
Subtype C
description Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross-sectional study was conducted from September to December 2002. Plasma viral RNA of 85 patients was extracted and protease and reverse transcriptase genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined to antiretroviral resistance mutations. Laboratory data and past history of antiretroviral treatment were also collected. Results: Most viruses were either subtype B (42%) or subtype C (45%). No risk behaviour, sexual orientation or laboratory parameter was associated with any specific subtype, but subtype C tended to be more frequently found in women (P ¼ 0.06). The prevalence of subtype C has increased over the HIV/AIDS epidemic, accounting for almost 60% of cases diagnosed in 2002. Intra-subtype genetic distances were smaller in subtype C than in subtype B, suggesting a more recent introduction of the former in the epidemic. Of patients under treatment, 60% had at least one antiretroviral drug resistance mutation, but no mutation was specifically associated with any HIV-1 subtype. Only one resistance mutation each was found in drug-naive patients with subtypes B and C. Conclusion: Despite the fact that subtype C appeared in southern Brazil more recently than subtype B, it is now the predominant strain in Rio Grande. The epidemic spread of subtype C could be taking place in Brazil, and possibly in south America, a phenomenon similar to that seen in other countries where this subtype is now totally dominant.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2013-06-17T18:10:29Z
dc.date.available.fl_str_mv 2013-06-17T18:10:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Esmeralda Augusta Jardim Machado et al. HIV1 subtype C dissemination in the southern Brazil. AIDS, London, v. 19, p. S81-S86, 2005. Disponível em: <http://journals.lww.com/aidsonline/Fulltext/2005/10004/HIV_1_subtype_C_dissemination_in_southern_Brazil.14.aspx>. Acesso em: 10 set. 2012.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/3534
dc.identifier.issn.none.fl_str_mv 0269-9370
identifier_str_mv SOARES, Esmeralda Augusta Jardim Machado et al. HIV1 subtype C dissemination in the southern Brazil. AIDS, London, v. 19, p. S81-S86, 2005. Disponível em: <http://journals.lww.com/aidsonline/Fulltext/2005/10004/HIV_1_subtype_C_dissemination_in_southern_Brazil.14.aspx>. Acesso em: 10 set. 2012.
0269-9370
url http://repositorio.furg.br/handle/1/3534
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FURG (RI FURG)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Repositório Institucional da FURG (RI FURG)
collection Repositório Institucional da FURG (RI FURG)
bitstream.url.fl_str_mv https://repositorio.furg.br/bitstream/1/3534/1/HIV-1%20subtype%20C%20dissemination%20in%20southern%20Brazil.pdf
https://repositorio.furg.br/bitstream/1/3534/2/license.txt
bitstream.checksum.fl_str_mv a01d4d08928639b3401ccf8579fd6462
d3be63d3b3eee02729709361dac69efe
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv
_version_ 1794069223501201408