Determinants of HIV-1 mother-to-child transmission in Southern Brazil

Detalhes bibliográficos
Autor(a) principal: Martínez,Ana M.B.
Data de Publicação: 2006
Outros Autores: Hora,Vanusa P. da, Santos,Adriana L. dos, Mendoza-Sassi,Raul, Von Groll,Andréa, Soares,Esmeralda A.J.M., D'Ávila,Nildo, Silveira,Jussara, Leal,Renata G., Tanuri,Amilcar, Soares,Marcelo A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000100011
Resumo: Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunological and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but few and controversial results have been described so far. In this study, 102 children born from HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed for potential risk factors associated with MTCT. That geographic region is characterized by a high proportion of subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence on MTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regression analyses were conducted to evaluate the influence of the parameters on MTCT, and prevalence ratios (PR) and 95% confidence intervals (CI95) were also calculated. A surprisingly high prevalence of subtype C of over 70% was found. Only the HIV viral load and the use of ACTG 076 protocol were predictive of MTCT. HIV subtype and CD4 T-cell counts were not associated with increased risk of transmission. Although a clear expansion of subtype C is evident in southern Brazil, it does not seem to correlate with increased risk of vertical transmission.
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spelling Determinants of HIV-1 mother-to-child transmission in Southern BrazilHIVMTCTvertical transmissionsubtype Cmolecular epidemiologyDifferent human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunological and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but few and controversial results have been described so far. In this study, 102 children born from HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed for potential risk factors associated with MTCT. That geographic region is characterized by a high proportion of subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence on MTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regression analyses were conducted to evaluate the influence of the parameters on MTCT, and prevalence ratios (PR) and 95% confidence intervals (CI95) were also calculated. A surprisingly high prevalence of subtype C of over 70% was found. Only the HIV viral load and the use of ACTG 076 protocol were predictive of MTCT. HIV subtype and CD4 T-cell counts were not associated with increased risk of transmission. Although a clear expansion of subtype C is evident in southern Brazil, it does not seem to correlate with increased risk of vertical transmission.Academia Brasileira de Ciências2006-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000100011Anais da Academia Brasileira de Ciências v.78 n.1 2006reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652006000100011info:eu-repo/semantics/openAccessMartínez,Ana M.B.Hora,Vanusa P. daSantos,Adriana L. dosMendoza-Sassi,RaulVon Groll,AndréaSoares,Esmeralda A.J.M.D'Ávila,NildoSilveira,JussaraLeal,Renata G.Tanuri,AmilcarSoares,Marcelo A.eng2006-03-08T00:00:00Zoai:scielo:S0001-37652006000100011Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2006-03-08T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Determinants of HIV-1 mother-to-child transmission in Southern Brazil
title Determinants of HIV-1 mother-to-child transmission in Southern Brazil
spellingShingle Determinants of HIV-1 mother-to-child transmission in Southern Brazil
Martínez,Ana M.B.
HIV
MTCT
vertical transmission
subtype C
molecular epidemiology
title_short Determinants of HIV-1 mother-to-child transmission in Southern Brazil
title_full Determinants of HIV-1 mother-to-child transmission in Southern Brazil
title_fullStr Determinants of HIV-1 mother-to-child transmission in Southern Brazil
title_full_unstemmed Determinants of HIV-1 mother-to-child transmission in Southern Brazil
title_sort Determinants of HIV-1 mother-to-child transmission in Southern Brazil
author Martínez,Ana M.B.
author_facet Martínez,Ana M.B.
Hora,Vanusa P. da
Santos,Adriana L. dos
Mendoza-Sassi,Raul
Von Groll,Andréa
Soares,Esmeralda A.J.M.
D'Ávila,Nildo
Silveira,Jussara
Leal,Renata G.
Tanuri,Amilcar
Soares,Marcelo A.
author_role author
author2 Hora,Vanusa P. da
Santos,Adriana L. dos
Mendoza-Sassi,Raul
Von Groll,Andréa
Soares,Esmeralda A.J.M.
D'Ávila,Nildo
Silveira,Jussara
Leal,Renata G.
Tanuri,Amilcar
Soares,Marcelo A.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martínez,Ana M.B.
Hora,Vanusa P. da
Santos,Adriana L. dos
Mendoza-Sassi,Raul
Von Groll,Andréa
Soares,Esmeralda A.J.M.
D'Ávila,Nildo
Silveira,Jussara
Leal,Renata G.
Tanuri,Amilcar
Soares,Marcelo A.
dc.subject.por.fl_str_mv HIV
MTCT
vertical transmission
subtype C
molecular epidemiology
topic HIV
MTCT
vertical transmission
subtype C
molecular epidemiology
description Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunological and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but few and controversial results have been described so far. In this study, 102 children born from HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed for potential risk factors associated with MTCT. That geographic region is characterized by a high proportion of subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence on MTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regression analyses were conducted to evaluate the influence of the parameters on MTCT, and prevalence ratios (PR) and 95% confidence intervals (CI95) were also calculated. A surprisingly high prevalence of subtype C of over 70% was found. Only the HIV viral load and the use of ACTG 076 protocol were predictive of MTCT. HIV subtype and CD4 T-cell counts were not associated with increased risk of transmission. Although a clear expansion of subtype C is evident in southern Brazil, it does not seem to correlate with increased risk of vertical transmission.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000100011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000100011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652006000100011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.78 n.1 2006
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
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