Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil

• Autor(a) principal: Martinez, Ana Maria Barral de
• Data de Publicação: 2002
• Outros Autores: Barbosa, Edel Figueirêdo, Ferreira, Paulo César Pelegrino, Cardoso, Fabiola Adriene, Silveira, Jussara Maria, Sassi, Gabriela, Silva, Claudio Moss da, Mendonça-Signorini, Vera, Antunes, Carlos Maurício de Figueiredo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da FURG (RI FURG)
• Texto Completo: http://repositorio.furg.br/handle/1/2491
• topic: Molecular epidemiology; HIV subtypes; Modes of transmission; Epidemiologia molecular; Subtipos do HIV; Modos de transmissão

We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%), C (22%) and F (3%). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices.