Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs

Detalhes bibliográficos
Autor(a) principal: Garcia,J. A. D.
Data de Publicação: 2015
Outros Autores: Souza,A. L. T., Cruz,L. H. C., Marques,P. P., Camilli,J. A., Nakagaki,W. R., Esteves,A., Rossi-Junior,W. C., Fernandes,G. J. M., Guerra,F. D., Soares,E. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842015000600983
Resumo: Abstract The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179±2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC – UNIFENAS.
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spelling Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femursethanolratsbonealcoholismdetoxificationAbstract The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179±2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC – UNIFENAS.Instituto Internacional de Ecologia2015-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842015000600983Brazilian Journal of Biology v.75 n.4 2015reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/1519-6984.04814info:eu-repo/semantics/openAccessGarcia,J. A. D.Souza,A. L. T.Cruz,L. H. C.Marques,P. P.Camilli,J. A.Nakagaki,W. R.Esteves,A.Rossi-Junior,W. C.Fernandes,G. J. M.Guerra,F. D.Soares,E. A.eng2015-12-11T00:00:00Zoai:scielo:S1519-69842015000600983Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2015-12-11T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false
dc.title.none.fl_str_mv Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
title Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
spellingShingle Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
Garcia,J. A. D.
ethanol
rats
bone
alcoholism
detoxification
title_short Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
title_full Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
title_fullStr Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
title_full_unstemmed Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
title_sort Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
author Garcia,J. A. D.
author_facet Garcia,J. A. D.
Souza,A. L. T.
Cruz,L. H. C.
Marques,P. P.
Camilli,J. A.
Nakagaki,W. R.
Esteves,A.
Rossi-Junior,W. C.
Fernandes,G. J. M.
Guerra,F. D.
Soares,E. A.
author_role author
author2 Souza,A. L. T.
Cruz,L. H. C.
Marques,P. P.
Camilli,J. A.
Nakagaki,W. R.
Esteves,A.
Rossi-Junior,W. C.
Fernandes,G. J. M.
Guerra,F. D.
Soares,E. A.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Garcia,J. A. D.
Souza,A. L. T.
Cruz,L. H. C.
Marques,P. P.
Camilli,J. A.
Nakagaki,W. R.
Esteves,A.
Rossi-Junior,W. C.
Fernandes,G. J. M.
Guerra,F. D.
Soares,E. A.
dc.subject.por.fl_str_mv ethanol
rats
bone
alcoholism
detoxification
topic ethanol
rats
bone
alcoholism
detoxification
description Abstract The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179±2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC – UNIFENAS.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842015000600983
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842015000600983
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1519-6984.04814
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Internacional de Ecologia
publisher.none.fl_str_mv Instituto Internacional de Ecologia
dc.source.none.fl_str_mv Brazilian Journal of Biology v.75 n.4 2015
reponame:Brazilian Journal of Biology
instname:Instituto Internacional de Ecologia (IIE)
instacron:IIE
instname_str Instituto Internacional de Ecologia (IIE)
instacron_str IIE
institution IIE
reponame_str Brazilian Journal of Biology
collection Brazilian Journal of Biology
repository.name.fl_str_mv Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)
repository.mail.fl_str_mv bjb@bjb.com.br||bjb@bjb.com.br
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