Kidney involvement in malaria: an update

Detalhes bibliográficos
Autor(a) principal: Silva Junior, Geraldo Bezerra da
Data de Publicação: 2017
Outros Autores: Pinto, José Reginaldo, Barros, Elvino José Guardão, Farias, Geysa Maria Nogueira, Daher, Elizabeth De Francesco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/140688
Resumo: Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury. Histologic studies in malaria also evidence glomerulonephritis, acute tubular necrosis and acute interstitial nephritis. It is also possible to find chronic kidney disease associated with malaria, mainly in those patients suffering from repeated episodes of infection. Plasmodium antigens have already been detected in the glomeruli, suggesting a direct effect of the parasite in the kidney, which can trigger an inflammatory process leading to different types of glomerulonephritis. Clinical manifestations of kidney involvement in malaria include proteinuria, microalbuminuria and urinary casts, reported in 20 to 50% of cases. Nephrotic syndrome has also been described in the infection by P. falciparum, but it is rare. This paper highlights the main aspects of kidney involvement in malaria and important findings of the most recent research addressing this issue.
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spelling Kidney involvement in malaria: an updateMalariaKidney diseaseAcute kidney injuryGlomerulonephritisChronic kidney disease Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury. Histologic studies in malaria also evidence glomerulonephritis, acute tubular necrosis and acute interstitial nephritis. It is also possible to find chronic kidney disease associated with malaria, mainly in those patients suffering from repeated episodes of infection. Plasmodium antigens have already been detected in the glomeruli, suggesting a direct effect of the parasite in the kidney, which can trigger an inflammatory process leading to different types of glomerulonephritis. Clinical manifestations of kidney involvement in malaria include proteinuria, microalbuminuria and urinary casts, reported in 20 to 50% of cases. Nephrotic syndrome has also been described in the infection by P. falciparum, but it is rare. This paper highlights the main aspects of kidney involvement in malaria and important findings of the most recent research addressing this issue.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/140688Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e53Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e53Revista do Instituto de Medicina Tropical de São Paulo; v. 59 (2017); e531678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/140688/135651https://www.revistas.usp.br/rimtsp/article/view/140688/147942Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessSilva Junior, Geraldo Bezerra daPinto, José ReginaldoBarros, Elvino José GuardãoFarias, Geysa Maria NogueiraDaher, Elizabeth De Francesco2018-02-23T18:46:03Zoai:revistas.usp.br:article/140688Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:41.514845Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Kidney involvement in malaria: an update
title Kidney involvement in malaria: an update
spellingShingle Kidney involvement in malaria: an update
Silva Junior, Geraldo Bezerra da
Malaria
Kidney disease
Acute kidney injury
Glomerulonephritis
Chronic kidney disease
title_short Kidney involvement in malaria: an update
title_full Kidney involvement in malaria: an update
title_fullStr Kidney involvement in malaria: an update
title_full_unstemmed Kidney involvement in malaria: an update
title_sort Kidney involvement in malaria: an update
author Silva Junior, Geraldo Bezerra da
author_facet Silva Junior, Geraldo Bezerra da
Pinto, José Reginaldo
Barros, Elvino José Guardão
Farias, Geysa Maria Nogueira
Daher, Elizabeth De Francesco
author_role author
author2 Pinto, José Reginaldo
Barros, Elvino José Guardão
Farias, Geysa Maria Nogueira
Daher, Elizabeth De Francesco
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva Junior, Geraldo Bezerra da
Pinto, José Reginaldo
Barros, Elvino José Guardão
Farias, Geysa Maria Nogueira
Daher, Elizabeth De Francesco
dc.subject.por.fl_str_mv Malaria
Kidney disease
Acute kidney injury
Glomerulonephritis
Chronic kidney disease
topic Malaria
Kidney disease
Acute kidney injury
Glomerulonephritis
Chronic kidney disease
description Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury. Histologic studies in malaria also evidence glomerulonephritis, acute tubular necrosis and acute interstitial nephritis. It is also possible to find chronic kidney disease associated with malaria, mainly in those patients suffering from repeated episodes of infection. Plasmodium antigens have already been detected in the glomeruli, suggesting a direct effect of the parasite in the kidney, which can trigger an inflammatory process leading to different types of glomerulonephritis. Clinical manifestations of kidney involvement in malaria include proteinuria, microalbuminuria and urinary casts, reported in 20 to 50% of cases. Nephrotic syndrome has also been described in the infection by P. falciparum, but it is rare. This paper highlights the main aspects of kidney involvement in malaria and important findings of the most recent research addressing this issue.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/140688
url https://www.revistas.usp.br/rimtsp/article/view/140688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/140688/135651
https://www.revistas.usp.br/rimtsp/article/view/140688/147942
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e53
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e53
Revista do Instituto de Medicina Tropical de São Paulo; v. 59 (2017); e53
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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