Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials

Detalhes bibliográficos
Autor(a) principal: Rocha,Werickson F. C.
Data de Publicação: 2012
Outros Autores: Nogueira,Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300003
Resumo: The supplemental Guide to the Expression of Uncertainty Measurement (2008), which deals with the propagation of distributions, encourages the use of the Monte Carlo simulation (MCS) for estimating the uncertainty of measurands. This paper describes the application of this method to estimate the measurement uncertainty of active pharmaceutical ingredient (API) mass fractions of two certified reference materials (CRMs): metronidazole and captopril. The Monte Carlo results complied with the GUM results in terms of the critical value d of 0.005 for metronidazole and 0.05 for captopril. Therefore, the Monte Carlo method validated the GUM through the expression of the API mass fraction with at least two decimal places.
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spelling Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materialsMonte Carlo simulationevaluation of measurement uncertaintycertified reference materialsactive pharmaceutical ingredientsThe supplemental Guide to the Expression of Uncertainty Measurement (2008), which deals with the propagation of distributions, encourages the use of the Monte Carlo simulation (MCS) for estimating the uncertainty of measurands. This paper describes the application of this method to estimate the measurement uncertainty of active pharmaceutical ingredient (API) mass fractions of two certified reference materials (CRMs): metronidazole and captopril. The Monte Carlo results complied with the GUM results in terms of the critical value d of 0.005 for metronidazole and 0.05 for captopril. Therefore, the Monte Carlo method validated the GUM through the expression of the API mass fraction with at least two decimal places.Sociedade Brasileira de Química2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300003Journal of the Brazilian Chemical Society v.23 n.3 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000300003info:eu-repo/semantics/openAccessRocha,Werickson F. C.Nogueira,Raqueleng2012-04-04T00:00:00Zoai:scielo:S0103-50532012000300003Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-04-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
title Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
spellingShingle Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
Rocha,Werickson F. C.
Monte Carlo simulation
evaluation of measurement uncertainty
certified reference materials
active pharmaceutical ingredients
title_short Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
title_full Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
title_fullStr Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
title_full_unstemmed Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
title_sort Monte Carlo simulation for the evaluation of measurement uncertainty of pharmaceutical certified reference materials
author Rocha,Werickson F. C.
author_facet Rocha,Werickson F. C.
Nogueira,Raquel
author_role author
author2 Nogueira,Raquel
author2_role author
dc.contributor.author.fl_str_mv Rocha,Werickson F. C.
Nogueira,Raquel
dc.subject.por.fl_str_mv Monte Carlo simulation
evaluation of measurement uncertainty
certified reference materials
active pharmaceutical ingredients
topic Monte Carlo simulation
evaluation of measurement uncertainty
certified reference materials
active pharmaceutical ingredients
description The supplemental Guide to the Expression of Uncertainty Measurement (2008), which deals with the propagation of distributions, encourages the use of the Monte Carlo simulation (MCS) for estimating the uncertainty of measurands. This paper describes the application of this method to estimate the measurement uncertainty of active pharmaceutical ingredient (API) mass fractions of two certified reference materials (CRMs): metronidazole and captopril. The Monte Carlo results complied with the GUM results in terms of the critical value d of 0.005 for metronidazole and 0.05 for captopril. Therefore, the Monte Carlo method validated the GUM through the expression of the API mass fraction with at least two decimal places.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012000300003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.3 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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