Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid

Detalhes bibliográficos
Autor(a) principal: Stojković, Dejan
Data de Publicação: 2013
Outros Autores: Davidović, Slobodan, Živković, Jelena, Glamočlija, Jasmina, Ćirić, Ana, Ferreira, Isabel C.F.R., Soković, Marina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/10581
Resumo: Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.
id RCAP_098b45de34588e441b8d97ea24bab3b9
oai_identifier_str oai:bibliotecadigital.ipb.pt:10198/10581
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acidAllium cepa assayAntimitoticAntimutagenicAmes testMorchella esculentaProtocatechuic acidMorchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.Serbian Ministry of Education, Science and Technological Development; FCT Portugal; COMPETE/QREN/EU, PTDC/AGR-ALI/110062/2009 PEst-OE/AGR/UI0690/2011Taylor&Francis LtdBiblioteca Digital do IPBStojković, DejanDavidović, SlobodanŽivković, JelenaGlamočlija, JasminaĆirić, AnaFerreira, Isabel C.F.R.Soković, Marina2014-09-24T16:50:48Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/10581engStojković, Dejan; Davidović, Slobodan; Živković, Jelena; Glamočlija, Jasmina; Ćirić, Ana; Ferreira, Isabel C.F.R.; Soković, Marina (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. Frontiers in Life Science. ISSN 2155-3769. 7:3-4, p. 218-2232155-376910.1080/21553769.2014.901925info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:25:13Zoai:bibliotecadigital.ipb.pt:10198/10581Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:01:25.298676Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
title Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
spellingShingle Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
Stojković, Dejan
Allium cepa assay
Antimitotic
Antimutagenic
Ames test
Morchella esculenta
Protocatechuic acid
title_short Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
title_full Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
title_fullStr Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
title_full_unstemmed Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
title_sort Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
author Stojković, Dejan
author_facet Stojković, Dejan
Davidović, Slobodan
Živković, Jelena
Glamočlija, Jasmina
Ćirić, Ana
Ferreira, Isabel C.F.R.
Soković, Marina
author_role author
author2 Davidović, Slobodan
Živković, Jelena
Glamočlija, Jasmina
Ćirić, Ana
Ferreira, Isabel C.F.R.
Soković, Marina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Stojković, Dejan
Davidović, Slobodan
Živković, Jelena
Glamočlija, Jasmina
Ćirić, Ana
Ferreira, Isabel C.F.R.
Soković, Marina
dc.subject.por.fl_str_mv Allium cepa assay
Antimitotic
Antimutagenic
Ames test
Morchella esculenta
Protocatechuic acid
topic Allium cepa assay
Antimitotic
Antimutagenic
Ames test
Morchella esculenta
Protocatechuic acid
description Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2014-09-24T16:50:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/10581
url http://hdl.handle.net/10198/10581
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Stojković, Dejan; Davidović, Slobodan; Živković, Jelena; Glamočlija, Jasmina; Ćirić, Ana; Ferreira, Isabel C.F.R.; Soković, Marina (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. Frontiers in Life Science. ISSN 2155-3769. 7:3-4, p. 218-223
2155-3769
10.1080/21553769.2014.901925
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor&Francis Ltd
publisher.none.fl_str_mv Taylor&Francis Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135246599323648