Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Detalhes bibliográficos
Autor(a) principal: Morais, Eduarda S.
Data de Publicação: 2019
Outros Autores: Silva, Nuno H. C. S., Sintra, Tânia E., Santos, Sónia A. O., Neves, Bruno Miguel, Almeida, Isabel F., Costa, Paulo C., Correia-Sá, Inês, Ventura, Sónia P. M., Silvestre, Armando J. D., Freire, Mara G., Freire, Carmen S. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/30235
Resumo: The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.
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spelling Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous applicationAntiinflammatory propertiesAntioxidant propertiesBacterial celluloseIonic liquidsPhenolic acidsSkin treatmentTopical applicationsThe utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.Elsevier2021-01-05T17:08:45Z2019-02-15T00:00:00Z2019-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/30235eng0144-861710.1016/j.carbpol.2018.10.051Morais, Eduarda S.Silva, Nuno H. C. S.Sintra, Tânia E.Santos, Sónia A. O.Neves, Bruno MiguelAlmeida, Isabel F.Costa, Paulo C.Correia-Sá, InêsVentura, Sónia P. M.Silvestre, Armando J. D.Freire, Mara G.Freire, Carmen S. R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:58:27Zoai:ria.ua.pt:10773/30235Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:02:23.152535Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
title Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
spellingShingle Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
Morais, Eduarda S.
Antiinflammatory properties
Antioxidant properties
Bacterial celluloseIonic liquids
Phenolic acids
Skin treatment
Topical applications
title_short Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
title_full Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
title_fullStr Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
title_full_unstemmed Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
title_sort Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application
author Morais, Eduarda S.
author_facet Morais, Eduarda S.
Silva, Nuno H. C. S.
Sintra, Tânia E.
Santos, Sónia A. O.
Neves, Bruno Miguel
Almeida, Isabel F.
Costa, Paulo C.
Correia-Sá, Inês
Ventura, Sónia P. M.
Silvestre, Armando J. D.
Freire, Mara G.
Freire, Carmen S. R.
author_role author
author2 Silva, Nuno H. C. S.
Sintra, Tânia E.
Santos, Sónia A. O.
Neves, Bruno Miguel
Almeida, Isabel F.
Costa, Paulo C.
Correia-Sá, Inês
Ventura, Sónia P. M.
Silvestre, Armando J. D.
Freire, Mara G.
Freire, Carmen S. R.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Morais, Eduarda S.
Silva, Nuno H. C. S.
Sintra, Tânia E.
Santos, Sónia A. O.
Neves, Bruno Miguel
Almeida, Isabel F.
Costa, Paulo C.
Correia-Sá, Inês
Ventura, Sónia P. M.
Silvestre, Armando J. D.
Freire, Mara G.
Freire, Carmen S. R.
dc.subject.por.fl_str_mv Antiinflammatory properties
Antioxidant properties
Bacterial celluloseIonic liquids
Phenolic acids
Skin treatment
Topical applications
topic Antiinflammatory properties
Antioxidant properties
Bacterial celluloseIonic liquids
Phenolic acids
Skin treatment
Topical applications
description The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-15T00:00:00Z
2019-02-15
2021-01-05T17:08:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/30235
url http://hdl.handle.net/10773/30235
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0144-8617
10.1016/j.carbpol.2018.10.051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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