Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties

Detalhes bibliográficos
Autor(a) principal: Silva, Cláudia
Data de Publicação: 2018
Outros Autores: Caridade, Sofia Glória Ferreira, Cunha, Eunice Paula Freitas, Sousa, Maria P., Rocha, Helena, Mano, J. F., Paiva, M. C., Alves, N. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/70268
Resumo: In the present work, novel freestanding multilayered films based on chitosan (CHI), alginate (ALG), and functionalized few-layer graphene are developed through layer-by-layer assembly. First, functionalized few-layer graphene aqueous suspensions are prepared from graphite by a stabilizer-assisted liquid phase exfoliation process, using a pyrene derivative as stabilizer. Afterward, the films are produced and their physical, morphological, thermal, and mechanical properties are evaluated. Furthermore, their degradation and swelling profiles, as well as their biological behavior, are assessed. The incorporation of functionalized few-layer graphene results in films with a nanolayered structure, lower roughness than the control CHI/ALG films, and hydrophilic behavior. The mechanical characterization reveals an increase of the Young's modulus, ultimate tensile strength, and elongation at break due to the incorporation of the graphene derivative. A decrease in the electrical resistivity of the multilayered films is also observed. The biological assays reveal improved cytocompatibility toward L929 cells when functionalized few-layer graphene is incorporated in the CHI/ALG matrix. Therefore, these new graphene-reinforced multilayered films exhibit interesting properties and great potential for biomedical applications, particularly in wound healing and cardiac and bone tissue engineering.
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spelling Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical propertiesBiomedical applicationsFreestanding multilayered filmsFunctionalized grapheneNatural polymersEngenharia e Tecnologia::Engenharia dos MateriaisScience & TechnologyIn the present work, novel freestanding multilayered films based on chitosan (CHI), alginate (ALG), and functionalized few-layer graphene are developed through layer-by-layer assembly. First, functionalized few-layer graphene aqueous suspensions are prepared from graphite by a stabilizer-assisted liquid phase exfoliation process, using a pyrene derivative as stabilizer. Afterward, the films are produced and their physical, morphological, thermal, and mechanical properties are evaluated. Furthermore, their degradation and swelling profiles, as well as their biological behavior, are assessed. The incorporation of functionalized few-layer graphene results in films with a nanolayered structure, lower roughness than the control CHI/ALG films, and hydrophilic behavior. The mechanical characterization reveals an increase of the Young's modulus, ultimate tensile strength, and elongation at break due to the incorporation of the graphene derivative. A decrease in the electrical resistivity of the multilayered films is also observed. The biological assays reveal improved cytocompatibility toward L929 cells when functionalized few-layer graphene is incorporated in the CHI/ALG matrix. Therefore, these new graphene-reinforced multilayered films exhibit interesting properties and great potential for biomedical applications, particularly in wound healing and cardiac and bone tissue engineering.The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) and the European program FEDER/COMPETE for the financial support through projects UID/Multi/50026/2013 and UID/CTM/50025/2013. This work was also financially supported by FCT through the scholarships SFRH/BPD/96797/2013 granted to Sofia G. Caridade, SFRH/BD/97606/2013 granted to Maria P. Sousa, and SFRH/BD/87214/2012 granted to Eunice CunhaWileyUniversidade do MinhoSilva, CláudiaCaridade, Sofia Glória FerreiraCunha, Eunice Paula FreitasSousa, Maria P.Rocha, HelenaMano, J. F.Paiva, M. C.Alves, N. M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/70268eng1438-74921439-205410.1002/mame.201700316https://onlinelibrary.wiley.com/doi/abs/10.1002/mame.201700316info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:46:18Zoai:repositorium.sdum.uminho.pt:1822/70268Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:44:16.872995Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
title Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
spellingShingle Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
Silva, Cláudia
Biomedical applications
Freestanding multilayered films
Functionalized graphene
Natural polymers
Engenharia e Tecnologia::Engenharia dos Materiais
Science & Technology
title_short Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
title_full Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
title_fullStr Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
title_full_unstemmed Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
title_sort Nanostructured biopolymer/few-layer graphene freestanding films with enhanced mechanical and electrical properties
author Silva, Cláudia
author_facet Silva, Cláudia
Caridade, Sofia Glória Ferreira
Cunha, Eunice Paula Freitas
Sousa, Maria P.
Rocha, Helena
Mano, J. F.
Paiva, M. C.
Alves, N. M.
author_role author
author2 Caridade, Sofia Glória Ferreira
Cunha, Eunice Paula Freitas
Sousa, Maria P.
Rocha, Helena
Mano, J. F.
Paiva, M. C.
Alves, N. M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Cláudia
Caridade, Sofia Glória Ferreira
Cunha, Eunice Paula Freitas
Sousa, Maria P.
Rocha, Helena
Mano, J. F.
Paiva, M. C.
Alves, N. M.
dc.subject.por.fl_str_mv Biomedical applications
Freestanding multilayered films
Functionalized graphene
Natural polymers
Engenharia e Tecnologia::Engenharia dos Materiais
Science & Technology
topic Biomedical applications
Freestanding multilayered films
Functionalized graphene
Natural polymers
Engenharia e Tecnologia::Engenharia dos Materiais
Science & Technology
description In the present work, novel freestanding multilayered films based on chitosan (CHI), alginate (ALG), and functionalized few-layer graphene are developed through layer-by-layer assembly. First, functionalized few-layer graphene aqueous suspensions are prepared from graphite by a stabilizer-assisted liquid phase exfoliation process, using a pyrene derivative as stabilizer. Afterward, the films are produced and their physical, morphological, thermal, and mechanical properties are evaluated. Furthermore, their degradation and swelling profiles, as well as their biological behavior, are assessed. The incorporation of functionalized few-layer graphene results in films with a nanolayered structure, lower roughness than the control CHI/ALG films, and hydrophilic behavior. The mechanical characterization reveals an increase of the Young's modulus, ultimate tensile strength, and elongation at break due to the incorporation of the graphene derivative. A decrease in the electrical resistivity of the multilayered films is also observed. The biological assays reveal improved cytocompatibility toward L929 cells when functionalized few-layer graphene is incorporated in the CHI/ALG matrix. Therefore, these new graphene-reinforced multilayered films exhibit interesting properties and great potential for biomedical applications, particularly in wound healing and cardiac and bone tissue engineering.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/70268
url http://hdl.handle.net/1822/70268
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1438-7492
1439-2054
10.1002/mame.201700316
https://onlinelibrary.wiley.com/doi/abs/10.1002/mame.201700316
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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