Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review

Detalhes bibliográficos
Autor(a) principal: Monteiro, Francisca Machado
Data de Publicação: 2021
Outros Autores: Sotiropoulos, I., Carvalho, Óscar Samuel Novais, Sousa, Nuno, Silva, Filipe Samuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/74200
Resumo: Alzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 40 million people worldwide. The ineffectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge. Mechanical vibrations delivered in different stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented elderly. Some of the mechanical-based stimulation modalities in efforts are earlier whole-body vibration, transcranial ultrasound stimulation with microbubble injection, and more recently, auditory stimulation. However, there is a huge variety of treatment specifications, and in many cases, conflicting results are reported. In this review, a search on Scopus, PubMed, and Web of Science databases was performed, resulting in 37 papers . These studies suggest that mechanical vibrations delivered through different stimulation modes are effective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity deficits in the brains of AD patients, as well as in subjects with cognitive decline and non-demented older adults. Despite the evolving preclinical and clinical evidence on these therapeutic modalities, their translation into clinical practice is not consolidated yet. Thus, this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.
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spelling Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic reviewAlzheimer’s diseaseAuditory stimulationMechanical vibrationsUltrasoundsWhole-body vibrationEngenharia e Tecnologia::Engenharia MédicaScience & TechnologySaúde de qualidadeAlzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 40 million people worldwide. The ineffectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge. Mechanical vibrations delivered in different stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented elderly. Some of the mechanical-based stimulation modalities in efforts are earlier whole-body vibration, transcranial ultrasound stimulation with microbubble injection, and more recently, auditory stimulation. However, there is a huge variety of treatment specifications, and in many cases, conflicting results are reported. In this review, a search on Scopus, PubMed, and Web of Science databases was performed, resulting in 37 papers . These studies suggest that mechanical vibrations delivered through different stimulation modes are effective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity deficits in the brains of AD patients, as well as in subjects with cognitive decline and non-demented older adults. Despite the evolving preclinical and clinical evidence on these therapeutic modalities, their translation into clinical practice is not consolidated yet. Thus, this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.FCT (Fundação para a Ciência e Tecnologia) through the grant with reference SFRH/BD/09375/2020, and in the scope of the projects UIDB/04436/2020, UIDP/04436/2020, and NORTE-01- 0145-FEDER-000023, funded by the European Fund for Regional Development (FEDER) of the Operational Programme for Competitiveness and Internationalization (POCI), by Portugal 2020.BioMed Central (BMC)Universidade do MinhoMonteiro, Francisca MachadoSotiropoulos, I.Carvalho, Óscar Samuel NovaisSousa, NunoSilva, Filipe Samuel2021-09-242021-09-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/74200engMonteiro, F., Sotiropoulos, I., Carvalho, Ó., Sousa, N., & Silva, F. S. (2021). Multi-mechanical waves against Alzheimer's disease pathology: a systematic review. Translational neurodegeneration, 10(1), 36.2047-91582047-915810.1186/s40035-021-00256-zhttps://pubmed.ncbi.nlm.nih.gov/34560902/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:28:53Zoai:repositorium.sdum.uminho.pt:1822/74200Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:23:45.871589Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
title Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
spellingShingle Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
Monteiro, Francisca Machado
Alzheimer’s disease
Auditory stimulation
Mechanical vibrations
Ultrasounds
Whole-body vibration
Engenharia e Tecnologia::Engenharia Médica
Science & Technology
Saúde de qualidade
title_short Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
title_full Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
title_fullStr Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
title_full_unstemmed Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
title_sort Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
author Monteiro, Francisca Machado
author_facet Monteiro, Francisca Machado
Sotiropoulos, I.
Carvalho, Óscar Samuel Novais
Sousa, Nuno
Silva, Filipe Samuel
author_role author
author2 Sotiropoulos, I.
Carvalho, Óscar Samuel Novais
Sousa, Nuno
Silva, Filipe Samuel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Monteiro, Francisca Machado
Sotiropoulos, I.
Carvalho, Óscar Samuel Novais
Sousa, Nuno
Silva, Filipe Samuel
dc.subject.por.fl_str_mv Alzheimer’s disease
Auditory stimulation
Mechanical vibrations
Ultrasounds
Whole-body vibration
Engenharia e Tecnologia::Engenharia Médica
Science & Technology
Saúde de qualidade
topic Alzheimer’s disease
Auditory stimulation
Mechanical vibrations
Ultrasounds
Whole-body vibration
Engenharia e Tecnologia::Engenharia Médica
Science & Technology
Saúde de qualidade
description Alzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 40 million people worldwide. The ineffectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge. Mechanical vibrations delivered in different stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented elderly. Some of the mechanical-based stimulation modalities in efforts are earlier whole-body vibration, transcranial ultrasound stimulation with microbubble injection, and more recently, auditory stimulation. However, there is a huge variety of treatment specifications, and in many cases, conflicting results are reported. In this review, a search on Scopus, PubMed, and Web of Science databases was performed, resulting in 37 papers . These studies suggest that mechanical vibrations delivered through different stimulation modes are effective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity deficits in the brains of AD patients, as well as in subjects with cognitive decline and non-demented older adults. Despite the evolving preclinical and clinical evidence on these therapeutic modalities, their translation into clinical practice is not consolidated yet. Thus, this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-24
2021-09-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/74200
url http://hdl.handle.net/1822/74200
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Monteiro, F., Sotiropoulos, I., Carvalho, Ó., Sousa, N., & Silva, F. S. (2021). Multi-mechanical waves against Alzheimer's disease pathology: a systematic review. Translational neurodegeneration, 10(1), 36.
2047-9158
2047-9158
10.1186/s40035-021-00256-z
https://pubmed.ncbi.nlm.nih.gov/34560902/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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