Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain

Detalhes bibliográficos
Autor(a) principal: Pinto, Daniel V.
Data de Publicação: 2020
Outros Autores: Raposo, Ramon S., Matos, Gabriella A., Alvarez-Leite, Jacqueline I., Malva, João O., Oriá, Reinaldo B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106118
https://doi.org/10.3389/fnins.2020.576543
Resumo: Mercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurotoxic levels, MeHg can lead to irreversible coma and, ultimately, death. It has been highlighted that MeHg long-term and low-grade toxicity may be associated with neurodegenerative disorders and perhaps a direct causality for Alzheimer’s disease (Siblerud et al., 2019). Although MeHg harmful effects to the brain have been thoroughly documented in the literature, such as increased oxidative stress and mitochondrial dysfunction, halted glutamate uptake by astrocytes and overt glutamate excitotoxicity, and activation of neuronal apoptosis cascades (Antunes dos Santos et al., 2016), less is known how MeHg affects the hippocampal neurogenic niche. Hence, in this opinion paper, we summarize up-to-date literature addressing MeHg effects on the intestinal microbiota, a key player influencing MeHg bioavailability and MeHg induction of intestinal dysbiosis (and vice-versa), and related intricate mechanisms during homeostasis and disease states. In addition, we discuss possible ways how MeHg may affect hippocampal neurogenesis and the potential lasting consequences for brain neurodegeneration.
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spelling Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brainmethylmercuryneurogenesisbrainintestinal microbiotaneurodegenerative diseasesgut dysbiosisMercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurotoxic levels, MeHg can lead to irreversible coma and, ultimately, death. It has been highlighted that MeHg long-term and low-grade toxicity may be associated with neurodegenerative disorders and perhaps a direct causality for Alzheimer’s disease (Siblerud et al., 2019). Although MeHg harmful effects to the brain have been thoroughly documented in the literature, such as increased oxidative stress and mitochondrial dysfunction, halted glutamate uptake by astrocytes and overt glutamate excitotoxicity, and activation of neuronal apoptosis cascades (Antunes dos Santos et al., 2016), less is known how MeHg affects the hippocampal neurogenic niche. Hence, in this opinion paper, we summarize up-to-date literature addressing MeHg effects on the intestinal microbiota, a key player influencing MeHg bioavailability and MeHg induction of intestinal dysbiosis (and vice-versa), and related intricate mechanisms during homeostasis and disease states. In addition, we discuss possible ways how MeHg may affect hippocampal neurogenesis and the potential lasting consequences for brain neurodegeneration.FEDER-CENTRO 2020- CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) and COMPETE and FCT (POCI-01-0145-FEDER- 029221 and UIDB/04539/2020), Pest-C/SAU/UI3282/2013-2014 and CNC.IBILI UID/NEU/04539/2013 with national funds PT2020/COMPETE 2020 and FCT/FUNCAP (POCTI-FEDER- 02/SAICT/2017/31699), Brazilian CAPES-PROCAD (071/2013 # 88881.068408/2014-01) and CNPq-PVE grantsFrontiers Media S.A.2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106118http://hdl.handle.net/10316/106118https://doi.org/10.3389/fnins.2020.576543eng1662-454833224022Pinto, Daniel V.Raposo, Ramon S.Matos, Gabriella A.Alvarez-Leite, Jacqueline I.Malva, João O.Oriá, Reinaldo B.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:25Zoai:estudogeral.uc.pt:10316/106118Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:35.031610Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
title Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
spellingShingle Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
Pinto, Daniel V.
methylmercury
neurogenesis
brain
intestinal microbiota
neurodegenerative diseases
gut dysbiosis
title_short Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
title_full Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
title_fullStr Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
title_full_unstemmed Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
title_sort Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neurogenic Niches in the Brain
author Pinto, Daniel V.
author_facet Pinto, Daniel V.
Raposo, Ramon S.
Matos, Gabriella A.
Alvarez-Leite, Jacqueline I.
Malva, João O.
Oriá, Reinaldo B.
author_role author
author2 Raposo, Ramon S.
Matos, Gabriella A.
Alvarez-Leite, Jacqueline I.
Malva, João O.
Oriá, Reinaldo B.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto, Daniel V.
Raposo, Ramon S.
Matos, Gabriella A.
Alvarez-Leite, Jacqueline I.
Malva, João O.
Oriá, Reinaldo B.
dc.subject.por.fl_str_mv methylmercury
neurogenesis
brain
intestinal microbiota
neurodegenerative diseases
gut dysbiosis
topic methylmercury
neurogenesis
brain
intestinal microbiota
neurodegenerative diseases
gut dysbiosis
description Mercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurotoxic levels, MeHg can lead to irreversible coma and, ultimately, death. It has been highlighted that MeHg long-term and low-grade toxicity may be associated with neurodegenerative disorders and perhaps a direct causality for Alzheimer’s disease (Siblerud et al., 2019). Although MeHg harmful effects to the brain have been thoroughly documented in the literature, such as increased oxidative stress and mitochondrial dysfunction, halted glutamate uptake by astrocytes and overt glutamate excitotoxicity, and activation of neuronal apoptosis cascades (Antunes dos Santos et al., 2016), less is known how MeHg affects the hippocampal neurogenic niche. Hence, in this opinion paper, we summarize up-to-date literature addressing MeHg effects on the intestinal microbiota, a key player influencing MeHg bioavailability and MeHg induction of intestinal dysbiosis (and vice-versa), and related intricate mechanisms during homeostasis and disease states. In addition, we discuss possible ways how MeHg may affect hippocampal neurogenesis and the potential lasting consequences for brain neurodegeneration.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106118
http://hdl.handle.net/10316/106118
https://doi.org/10.3389/fnins.2020.576543
url http://hdl.handle.net/10316/106118
https://doi.org/10.3389/fnins.2020.576543
dc.language.iso.fl_str_mv eng
language eng
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33224022
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dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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