Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders

Detalhes bibliográficos
Autor(a) principal: Carvalho, I. M.
Data de Publicação: 2015
Outros Autores: Barata, Pedro, Costa, P. C., Marques, C. S., Oliveira, Rita, Ferreira, D. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/10666
Resumo: The adult central nervous system is commonly known to have a very limited regenerative capacity. The presence of functional stem cells in the brain can therefore be seen as a paradox, since in other organs these are known to counterbalance cell loss derived from pathological conditions. This fact has therefore raised the possibility to stimulate neural stem cell differentiation and proliferation or survival by either stem cell replacement therapy or direct administration of neurotrophic factors or other proneurogenic molecules, which in turn has also originated regenerative medicine for the treatment of otherwise incurable neurodegenerative and neuropsychiatric disorders that take a huge toll on society. This may be facilitated by the fact that many of these disorders converge on similar pathophysiological pathways: excitotoxicity, oxidative stress, neuroinflammation, mitochondrial failure, excessive intracellular calcium and apoptosis. This review will therefore focus on the most promising achievements in promoting neuroprotection and neuroregeneration reported to date.
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spelling Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disordersNeurogenesisNeurotrophic factorsNeural stem cellsNeurodegenerative disordersRetinoic acidCurcuminoidsThe adult central nervous system is commonly known to have a very limited regenerative capacity. The presence of functional stem cells in the brain can therefore be seen as a paradox, since in other organs these are known to counterbalance cell loss derived from pathological conditions. This fact has therefore raised the possibility to stimulate neural stem cell differentiation and proliferation or survival by either stem cell replacement therapy or direct administration of neurotrophic factors or other proneurogenic molecules, which in turn has also originated regenerative medicine for the treatment of otherwise incurable neurodegenerative and neuropsychiatric disorders that take a huge toll on society. This may be facilitated by the fact that many of these disorders converge on similar pathophysiological pathways: excitotoxicity, oxidative stress, neuroinflammation, mitochondrial failure, excessive intracellular calcium and apoptosis. This review will therefore focus on the most promising achievements in promoting neuroprotection and neuroregeneration reported to date.Springer Science + Business MediaRepositório Institucional da Universidade Fernando PessoaCarvalho, I. M.Barata, PedroCosta, P. C.Marques, C. S.Oliveira, RitaFerreira, D. C.2022-01-26T12:55:32Z2015-01-01T00:00:00Z2015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/10666eng1535-108410.1007/s12017-015-8369-3metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:09:56Zoai:bdigital.ufp.pt:10284/10666Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:47:25.761688Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
title Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
spellingShingle Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
Carvalho, I. M.
Neurogenesis
Neurotrophic factors
Neural stem cells
Neurodegenerative disorders
Retinoic acid
Curcuminoids
title_short Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
title_full Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
title_fullStr Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
title_full_unstemmed Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
title_sort Current neurogenic and neuroprotective strategies to prevent and treat neurodegenerative and neuropsychiatric disorders
author Carvalho, I. M.
author_facet Carvalho, I. M.
Barata, Pedro
Costa, P. C.
Marques, C. S.
Oliveira, Rita
Ferreira, D. C.
author_role author
author2 Barata, Pedro
Costa, P. C.
Marques, C. S.
Oliveira, Rita
Ferreira, D. C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Carvalho, I. M.
Barata, Pedro
Costa, P. C.
Marques, C. S.
Oliveira, Rita
Ferreira, D. C.
dc.subject.por.fl_str_mv Neurogenesis
Neurotrophic factors
Neural stem cells
Neurodegenerative disorders
Retinoic acid
Curcuminoids
topic Neurogenesis
Neurotrophic factors
Neural stem cells
Neurodegenerative disorders
Retinoic acid
Curcuminoids
description The adult central nervous system is commonly known to have a very limited regenerative capacity. The presence of functional stem cells in the brain can therefore be seen as a paradox, since in other organs these are known to counterbalance cell loss derived from pathological conditions. This fact has therefore raised the possibility to stimulate neural stem cell differentiation and proliferation or survival by either stem cell replacement therapy or direct administration of neurotrophic factors or other proneurogenic molecules, which in turn has also originated regenerative medicine for the treatment of otherwise incurable neurodegenerative and neuropsychiatric disorders that take a huge toll on society. This may be facilitated by the fact that many of these disorders converge on similar pathophysiological pathways: excitotoxicity, oxidative stress, neuroinflammation, mitochondrial failure, excessive intracellular calcium and apoptosis. This review will therefore focus on the most promising achievements in promoting neuroprotection and neuroregeneration reported to date.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01T00:00:00Z
2015-01-01T00:00:00Z
2022-01-26T12:55:32Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/10666
url http://hdl.handle.net/10284/10666
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1535-1084
10.1007/s12017-015-8369-3
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dc.publisher.none.fl_str_mv Springer Science + Business Media
publisher.none.fl_str_mv Springer Science + Business Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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