Severe megaloblastic anaemia in an infant

Detalhes bibliográficos
Autor(a) principal: Rodrigues, V
Data de Publicação: 2011
Outros Autores: Dias, A, Brito, MJ, Galvão, I, Ferreira, GC
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/1488
Resumo: Vitamin B(12) or cobalamin deficiency, a rare clinical entity in pediatric age, is found most exclusively in breastfed infants, whose mothers are strictly vegetarian non-supplemented or with pernicious anaemia. In this article, the authors describe a 10-month-old infant admitted for vomiting, refusal to eat and prostration. The infant was exclusively breastfed and difficulties in introduction of new foods were reported. Failure to thrive since 5 months of age was also noticed. Laboratory evaluation revealed severe normocytic normochromic anaemia and cobalamin deficit. A diagnosis of α-thalassemia trait was also made. Maternal investigation showed autoimmune pernicious anaemia. This case shows the severity of vitamin B(12) deficiency and the importance of adopting adequate and precocious measures in order to prevent potentially irreversible neurologic damage.
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spelling Severe megaloblastic anaemia in an infantMegaloblastic anaemiaInfantBreast feedingVitamin B(12) deficiencyVitamin B(12) or cobalamin deficiency, a rare clinical entity in pediatric age, is found most exclusively in breastfed infants, whose mothers are strictly vegetarian non-supplemented or with pernicious anaemia. In this article, the authors describe a 10-month-old infant admitted for vomiting, refusal to eat and prostration. The infant was exclusively breastfed and difficulties in introduction of new foods were reported. Failure to thrive since 5 months of age was also noticed. Laboratory evaluation revealed severe normocytic normochromic anaemia and cobalamin deficit. A diagnosis of α-thalassemia trait was also made. Maternal investigation showed autoimmune pernicious anaemia. This case shows the severity of vitamin B(12) deficiency and the importance of adopting adequate and precocious measures in order to prevent potentially irreversible neurologic damage.BMJ Pub. GroupRepositório do Hospital Prof. Doutor Fernando FonsecaRodrigues, VDias, ABrito, MJGalvão, IFerreira, GC2015-08-14T14:37:13Z2011-01-01T00:00:00Z2011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/1488engBMJ Case Rep. 2011 May 16;2011. pii: bcr022011383510.1136/bcr.02.2011.3835info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:15Zoai:repositorio.hff.min-saude.pt:10400.10/1488Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:52:32.786696Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Severe megaloblastic anaemia in an infant
title Severe megaloblastic anaemia in an infant
spellingShingle Severe megaloblastic anaemia in an infant
Rodrigues, V
Megaloblastic anaemia
Infant
Breast feeding
Vitamin B(12) deficiency
title_short Severe megaloblastic anaemia in an infant
title_full Severe megaloblastic anaemia in an infant
title_fullStr Severe megaloblastic anaemia in an infant
title_full_unstemmed Severe megaloblastic anaemia in an infant
title_sort Severe megaloblastic anaemia in an infant
author Rodrigues, V
author_facet Rodrigues, V
Dias, A
Brito, MJ
Galvão, I
Ferreira, GC
author_role author
author2 Dias, A
Brito, MJ
Galvão, I
Ferreira, GC
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Rodrigues, V
Dias, A
Brito, MJ
Galvão, I
Ferreira, GC
dc.subject.por.fl_str_mv Megaloblastic anaemia
Infant
Breast feeding
Vitamin B(12) deficiency
topic Megaloblastic anaemia
Infant
Breast feeding
Vitamin B(12) deficiency
description Vitamin B(12) or cobalamin deficiency, a rare clinical entity in pediatric age, is found most exclusively in breastfed infants, whose mothers are strictly vegetarian non-supplemented or with pernicious anaemia. In this article, the authors describe a 10-month-old infant admitted for vomiting, refusal to eat and prostration. The infant was exclusively breastfed and difficulties in introduction of new foods were reported. Failure to thrive since 5 months of age was also noticed. Laboratory evaluation revealed severe normocytic normochromic anaemia and cobalamin deficit. A diagnosis of α-thalassemia trait was also made. Maternal investigation showed autoimmune pernicious anaemia. This case shows the severity of vitamin B(12) deficiency and the importance of adopting adequate and precocious measures in order to prevent potentially irreversible neurologic damage.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01T00:00:00Z
2011-01-01T00:00:00Z
2015-08-14T14:37:13Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.10/1488
url http://hdl.handle.net/10400.10/1488
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMJ Case Rep. 2011 May 16;2011. pii: bcr0220113835
10.1136/bcr.02.2011.3835
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